Results 1 to 10 of about 1,306 (173)

From Orange to Oncology: Anti-Inflammatory and Anti-Cancer Mechanisms of Sinensetin [PDF]

Cells
Sinensetin, a polymethoxylated flavone abundant in citrus fruits, has been recognized for its broad biological activities and wide use in traditional medicine around the world. Emerging clinical evidence from flavonoid-enriched orange juice interventions
Dong Joon Kim, Songyeon Ahn, Xiaomeng Xie, Yeon-Sun Seong, Yong Weon Yi   +4 more
doaj   +5 more sources

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice [PDF]

Frontiers in Pharmacology
ObjectiveHepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes.
Guanghua Xiong
exaly   +6 more sources

Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity [PDF]

Frontiers in Pharmacology, 2021
Sinensetin, a plant-derived polymethoxylated flavonoid found in Orthosiphon aristatus var. aristatus and several citrus fruits, has been found to possess strong anticancer activities and a variety of other pharmacological benefits and promising potency ...
Ibrahim Jantan, Juriyati Jalil, Husain K   +2 more
exaly   +5 more sources

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization [PDF]

Journal of Translational Medicine
Osteoporosis is a skeletal condition caused by an excess of osteoclasts, resulting in an imbalance in bone metabolism. Sinensetin (SIN), one of the main ingredients in citrus fruits, provides a variety of pharmacological properties, like antioxidant, but
Yijie Gao, Rui Zhou, Xixi Lin, Zhijuan Liu, Yuangang Su, Haoyu Lian, Bin Lin, Xiaofei Ding, Shijie Liao, Xiangde Li, Jinmin Zhao, Jiake Xu, Ren Xu, Qian Liu, Fangming Song   +14 more
doaj   +4 more sources

Sinensetin ameliorates established high-fat diet-induced liver injury and intestinal barrier dysfunction through the mitophagy/TLR4/MAPK signaling pathway [PDF]

Frontiers in Nutrition
IntroductionLong-term consumption of a high-fat diet (HFD) causes liver injury characterized by steatosis, inflammation, and fibrosis. Mitophagy, as a selective autophagy, is reported to be involved in the regulation of liver injury.
Zhuoqun Meng, Qin Zhang, Zhichang Zhao, Yuan Zhang, Zhijie Lu, Guirong Liu, Wenliang Xiang, Qing Zhang, Jie Tang, Jie Tang   +9 more
doaj   +2 more sources

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin [PDF]

Discover Oncology
Breast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance.
Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio   +4 more
doaj   +2 more sources

Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins [PDF]

Scientific Reports
Strobilanthes sarcorrhiza, a characteristic medicinal plant in China, has been traditionally used for nourishing yin and tonifying kidneys through its fleshy roots.
Wenyuan Xie, Hongdi Gao, Zhenxian Zhu, Xiaowei Xu, Yaojun Ying, Yongyi Yan, Lan Ding, Guoqing Wu   +7 more
doaj   +2 more sources

Metabolomics Reveals the Dynamic Characteristics of Flavonoids During the Different Developmental Stages of Citrus reticulata ‘Shiyue Ju’ and Its Mutant C. reticulata ‘Denglong Ju’ [PDF]

Current Issues in Molecular Biology
Flavonoids, prominent bioactive compounds in citrus fruits, exhibit diverse health-promoting properties. However, the dynamic compositional changes in flavonoids during fruit development remain insufficiently characterized in Citrus reticulata ‘Shiyue Ju’
Qin Guan, Doudou Huang, Lan Zhang, Zongyou Lv   +3 more
doaj   +2 more sources

Bioguided Identification of Polymethoxyflavones as Novel Vascular Ca_V1.2 Channel Blockers from Citrus Peel [PDF]

Molecules
The huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities.
Anna Ramunno, Rosa Maria Vitale, Pietro Amodeo, Carlo Crescenzi, Alice Panti, Paolo Fiorenzani, Michele De Luca, Umile Gianfranco Spizzirri, Donatella Restuccia, Francesca Aiello, Fabio Fusi   +10 more
doaj   +2 more sources

Sinensetin attenuates post-stroke depression via dual modulation of TLR4/NF-κB–NRF2/GPX4 pathways [PDF]

Scientific Reports
Post-stroke depression (PSD) is a complex neuropsychiatric complication driven by neuroinflammation and ferroptosis, yet effective therapies remain limited.
Qiqi Fan, Renfeng Huang, Kunling Luo, Jiaxin Chen, Xuanying Yin, Erjuan Zhao, Yuanyue Liu, Lei Sheng, Qi Wang, Weiwu Cai   +9 more
doaj   +2 more sources