Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice [PDF]
Frontiers in PharmacologyObjectiveHepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes.
Guanghua Xiong
exaly +4 more sources
From Orange to Oncology: Anti-Inflammatory and Anti-Cancer Mechanisms of Sinensetin [PDF]
CellsSinensetin, a polymethoxylated flavone abundant in citrus fruits, has been recognized for its broad biological activities and wide use in traditional medicine around the world. Emerging clinical evidence from flavonoid-enriched orange juice interventions
Dong Joon Kim +4 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 The incidence of pulmonary fibrosis (PF), a progressively fatal disease, has increased in recent years. However, there are no effective medicines available. Previous results have shown that sinensetin probably has some curative effects on PF.
Yong Xu, Xianmei Zhou, Qi Wu
exaly +3 more sources
Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity
Frontiers in Pharmacology, 2021 Sinensetin, a plant-derived polymethoxylated flavonoid found in Orthosiphon aristatus var. aristatus and several citrus fruits, has been found to possess strong anticancer activities and a variety of other pharmacological benefits and promising potency ...
Ibrahim Jantan +2 more
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Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin [PDF]
Discover OncologyBreast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance.
Adam Hermawan +4 more
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Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins [PDF]
Scientific ReportsStrobilanthes sarcorrhiza, a characteristic medicinal plant in China, has been traditionally used for nourishing yin and tonifying kidneys through its fleshy roots.
Wenyuan Xie +7 more
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Bioguided Identification of Polymethoxyflavones as Novel Vascular CaV1.2 Channel Blockers from Citrus Peel [PDF]
MoleculesThe huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities.
Anna Ramunno +10 more
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Sinensetin attenuates post-stroke depression via dual modulation of TLR4/NF-κB–NRF2/GPX4 pathways [PDF]
Scientific ReportsPost-stroke depression (PSD) is a complex neuropsychiatric complication driven by neuroinflammation and ferroptosis, yet effective therapies remain limited.
Qiqi Fan +9 more
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Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization [PDF]
Journal of Translational MedicineOsteoporosis is a skeletal condition caused by an excess of osteoclasts, resulting in an imbalance in bone metabolism. Sinensetin (SIN), one of the main ingredients in citrus fruits, provides a variety of pharmacological properties, like antioxidant, but
Yijie Gao +14 more
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Utilizing network pharmacology and other tools to examine active components and mechanism of action of Magnolia officinalis rheum rhabarbarum decoction in treating Streptococcus pyogenes skin infections [PDF]
Bioresources and BioprocessingInfections caused by Streptococcus pyogenes and the growing threat of antibiotic resistance pose significant global health challenges. This study investigates the antibacterial properties of Magnolia officinalis Rheum rhabarbarum Decoction against ...
Yuanhao Wang +6 more
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