Results 11 to 20 of about 946 (153)

The Potential Role of Rosmarinic Acid and Sinensetin as α-Amylase Inhibitor: In Silico Study [PDF]

Journal of Pure and Applied Chemistry Research, 2019
The study of natural compound as α-amylase inhibitor has been a concern since the synthetic drugs for the management of type 2 diabetes mellitus have several side effects.
Hazna Noor Meidinna, Fatchiyah Fatchiyah   +1 more
doaj   +3 more sources

Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings [PDF]

BMC Complementary Medicine and Therapies, 2020
Background Human respiratory system infected with influenza A virus (IAV) elicited a robust pro-inflammatory response that resulted in severe illness and even death.
Jiashun Li, Xiang Jie, Xiaoli Liang, Ziyu Chen, Peifang Xie, Xiping Pan, Beixian Zhou, Jing Li   +7 more
doaj   +3 more sources

Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2021
Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body.
Intan Kris Prasetyanti, Sukardiman, Suharjono   +2 more
doaj   +3 more sources

Sinensetin regulates age-related sarcopenia in cultured primary thigh and calf muscle cells [PDF]

BMC Complementary and Alternative Medicine, 2019
Background Sarcopenia, the decline of skeletal muscle tissue attributed to primary aging is a major concern in older adults. Flavonoids might have potential benefits by modulating the regulation of satellite cells, thus preventing muscle loss. Sinensetin
Jin-A Kim, Seong Min Kim, Sang Eun Ha, Preethi Vetrivel, Venu Venkatarame Gowda Saralamma, Eun Hee Kim, Gon Sup Kim   +6 more
doaj   +3 more sources

Effects of Sinensetin, Eupatilin, and Jaceosidin on Human Melanogenesis: A Pilot Study

Future Pharmacology
Background/Objectives: Flavones, a class of plant-based flavonoids, have demonstrated conflicting anti-melanogenic activities in mouse and human melanocytes.
Shilpi Goenka
doaj   +2 more sources

Identification of Citri Reticulatae Pericarpium (Chenpi) From Different Cultivars via LC-MS/MS and UPLC Coupled With Multivariate Chemometrics Analysis. [PDF]

Food Sci Nutr
A UPLC‐based quantitative analysis combined with multivariate chemometric methods differentiated seven Citri Reticulatae Pericarpium cultivars based on significant variations in nine flavonoids. Chemometric analysis effectively separated the seven cultivars, and hesperetin was identified as a unique marker for C. reticulata “Chachi”.
Lin D, Zhang J, Chen M, Zhong C, Cao H, Ma Z, Wu M, Zhang Y.   +7 more
europepmc   +2 more sources

Evaluation of Sinensetin Derived From Flavonoids-Rich Orthosiphon Stamineus as a New Radiosensitizer in MDA-MB-231 and T47D as Breast Cancer Cell Lines [PDF]

Iranian Journal of Medical Physics, 2023
Introduction: Breast cancer is one of the most prevalent diseases around the world. Breast cancer patients treated with radiation may face Side effects as well as cancer recurrence. Some polyphenols exhibit antioxidant effects.
Nakisa Rezakhani, Bahram Goliaei, Fereshte Mahdizade, Alireza Nikoofar, Hoda Keshmiri Neghab, -Mohammad Hasan Soheilifar, Seyedeh Sara Azadeh, Bahareh Bigdeli   +7 more
doaj   +1 more source

Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling

ACS Omega, 2023
Macrophage-mediated inflammation plays essential roles in multiple-organ injury. Sinensetin (SNS) at least exhibits anti-inflammation, antioxidant, and antitumor properties. However, the underlying mechanism of SNS-targeted macrophage-mediated inflammation remains elusive. In the present study, our results showed that SNS suppressed lipopolysaccharide (
Lin Lin, Kuimiao Deng, Zongrong Gong, Huifeng Fan, Dongwei Zhang, Gen Lu   +5 more
doaj   +3 more sources

Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress [PDF]

International Journal of Oral Science
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm. The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.
Zhiyao Yuan, Junjie Li, Fuyu Xiao, Yu Wu, Zhiting Zhang, Jiahong Shi, Jun Qian, Xudong Wu, Fuhua Yan   +8 more
doaj   +2 more sources

α-Glucosidase Inhibitory Potential of <i>Citrus reticulata</i> Peel-Derived Flavonoids-A Prelude for the Management of Type 2 Diabetes. [PDF]

Food Sci Nutr
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Baloyi IT, Rabbad AH, Gama NH, Malgas S.
europepmc   +2 more sources