Results 21 to 30 of about 1,893 (191)

Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling

ACS Omega, 2023
Macrophage-mediated inflammation plays essential roles in multiple-organ injury. Sinensetin (SNS) at least exhibits anti-inflammation, antioxidant, and antitumor properties. However, the underlying mechanism of SNS-targeted macrophage-mediated inflammation remains elusive. In the present study, our results showed that SNS suppressed lipopolysaccharide (
Lin Lin, Kuimiao Deng, Zongrong Gong, Huifeng Fan, Dongwei Zhang, Gen Lu   +5 more
doaj   +3 more sources

Effects of Sinensetin, Eupatilin, and Jaceosidin on Human Melanogenesis: A Pilot Study

Future Pharmacology
Background/Objectives: Flavones, a class of plant-based flavonoids, have demonstrated conflicting anti-melanogenic activities in mouse and human melanocytes.
Shilpi Goenka
doaj   +2 more sources

Identification of Citri Reticulatae Pericarpium (Chenpi) From Different Cultivars via LC-MS/MS and UPLC Coupled With Multivariate Chemometrics Analysis. [PDF]

Food Sci Nutr
A UPLC‐based quantitative analysis combined with multivariate chemometric methods differentiated seven Citri Reticulatae Pericarpium cultivars based on significant variations in nine flavonoids. Chemometric analysis effectively separated the seven cultivars, and hesperetin was identified as a unique marker for C. reticulata “Chachi”.
Lin D, Zhang J, Chen M, Zhong C, Cao H, Ma Z, Wu M, Zhang Y.   +7 more
europepmc   +2 more sources

Evaluation of Sinensetin Derived From Flavonoids-Rich Orthosiphon Stamineus as a New Radiosensitizer in MDA-MB-231 and T47D as Breast Cancer Cell Lines [PDF]

Iranian Journal of Medical Physics, 2023
Introduction: Breast cancer is one of the most prevalent diseases around the world. Breast cancer patients treated with radiation may face Side effects as well as cancer recurrence. Some polyphenols exhibit antioxidant effects.
Nakisa Rezakhani, Bahram Goliaei, Fereshte Mahdizade, Alireza Nikoofar, Hoda Keshmiri Neghab, -Mohammad Hasan Soheilifar, Seyedeh Sara Azadeh, Bahareh Bigdeli   +7 more
doaj   +1 more source

α-Glucosidase Inhibitory Potential of <i>Citrus reticulata</i> Peel-Derived Flavonoids-A Prelude for the Management of Type 2 Diabetes. [PDF]

Food Sci Nutr
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Baloyi IT, Rabbad AH, Gama NH, Malgas S.
europepmc   +2 more sources

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage. [PDF]

Adv Sci (Weinh)
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Su J, Zhang S, Liang L, Bai H, Bai M, He H, Wang Y, Liu H, Liang X, Sun Y, Wu H.   +10 more
europepmc   +2 more sources

Optimization Method and Stability Test to Determinate Luteolin, Quercetin, Apigenin, and Sinensetin Levels in Herbal Medicines Using TLC-Densitometry

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: Nephrolithiasis is a condition in which there are one or more kidney stones in the pelvis or calyces. Luteolin, quercetin, apigenin, and sinensetin are marker compounds in the extracts of Plantago major, Sonchus arvensis, Strobilanthes ...
Muhammad Hidayatullah, Mochammad Yuwono, Riesta Primaharinastiti   +2 more
doaj   +1 more source

<i>Exocarpium Citri Grandis</i> Ameliorates Metabolic Disorders by Inhibiting Inflammatory Responses and NLRP3 Inflammasome Activation. [PDF]

Food Sci Nutr
Exocarpium Citri Grandis (ECG, Huajuhong in Chinese), as the fruit of a plant that can be used both as medicine and food, has gained attention for hypolipidemic and anti‐obesity effects. To our knowledge, this is an innovative study based on in vivo and in vitro experiments aimed at exploring the pharmacological mechanisms of ECG in ameliorating MS ...
Chen T, Wu X, Wang D, Cui T, Li J, Zhang Z, Qiu M, Ma C, Liu H, Gao Y, Zeng J, Li H, Huang J.   +12 more
europepmc   +2 more sources

HPLC Method Optimization for Simultaneous Determination of Quercetin, Luteolin, Sinensetin, and Stigmasterol in Herbal Medicines

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: Quercetin, luteolin, sinensetin and stigmasterol each is the main marker compound in extracts of Sonchus arvensis, Plantago major, Orthosiphon stamineus, and Strobilanthes crispus, respectively.
Asih Imulda Hari Purwani, Riesta Primaharinastiti, Mochammad Yuwono   +2 more
doaj   +1 more source

Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway

Frontiers in Pharmacology, 2021
As a common degenerative disease, osteoarthritis (OA) usually causes disability in the elderly and socioeconomic burden. Previous studies have shown that proper autophagy has a protective effect on OA.
Wenxian Zhou, Wenxian Zhou, Wenxian Zhou, Yifeng Shi, Yifeng Shi, Yifeng Shi, Hui Wang, Hui Wang, Hui Wang, Caiyu Yu, Huanqing Zhu, Aimin Wu, Aimin Wu, Aimin Wu   +13 more
doaj   +1 more source