Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis [PDF]
Frontiers in PharmacologyBackground and aimBenign prostatic hyperplasia (BPH) involves androgen-driven proliferation with reduced apoptosis. Current 5α-reductase inhibitors can cause adverse effects, motivating safer options.
Jun-Hui Song +12 more
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Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions [PDF]
Discover OncologyBackground & objectives The introduction of traditional Chinese medicine to the treatment of breast cancer increases the risk of adverse herb-herb interactions.
Hongming Song +6 more
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Nobiletin Attenuates Adipogenesis and Promotes Browning in 3T3-L1 Adipocytes Through Exosomal miRNA-Mediated AMPK Activation [PDF]
Current Issues in Molecular BiologyNobiletin, a citrus-derived polymethoxylated flavone, has been reported to exert anti-obesity effects, but its molecular mechanisms remain poorly understood.
Shweta Chauhan +4 more
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Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism [PDF]
Molecular MedicineThe incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but effective interventions are currently unavailable.
Ni Yang +4 more
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Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2 [PDF]
E3S Web of Conferences, 2021 To explore the potential mechanism of nobiletin in improving the sensitivity of breast cancer MDA-MB-231 cells to Pirarubicin. MDA-MB-231 cells were randomly divided into Control group, Nobiletin group, Pirarubicin group and Nobiletin co-Pirarubicin ...
Yuan Fahu, Liao Xinghua, Zhang Tongcun
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Phytomedicine Plus, 2022 Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes.
Yukiko K. Kaneko +5 more
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Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats
Scientific Reports, 2022 This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension.
Metee Iampanichakul +7 more
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Cancer Biology & Medicine, 2021 Objective: Natural extracts, including nobiletin, have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs. However, whether and how nobiletin affects tumor growth and progression in renal cell carcinoma (RCC) are still ...
Tingting Chen +8 more
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Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis
Kaohsiung Journal of Medical Sciences, 2021 Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. However, the biological function of nobiletin in breast cancer (BC) is largely unknown.
Ji‐Guo Wang +3 more
doaj +1 more source
A review on recent advances on nobiletin in central and peripheral nervous system diseases
European Journal of Medical Research, 2023 In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited.
Yueshan Pang +3 more
doaj +1 more source