Effect of nobiletin on experimental model of epilepsy [PDF]
Translational Neuroscience, 2018 The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
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Mitochondrial Target of Nobiletin's Action [PDF]
Natural Product Communications, 2016 Nobiletin is an O -methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective, anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties.
Nino Sharikadze +4 more
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Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
Biological and Pharmaceutical Bulletin, 2010 A growing body of evidence suggests that nobiletin (5,6,7,8,3',4'-hexamethoxy flavone) from the peel of citrus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated.
Sang Jeong Kim +2 more
exaly +5 more sources
Unraveling the Bioactive Compounds and Multi-Target Mechanisms of the Fructus Aurantii Immaturus-Bambusae Caulis in Taeniam Herb Pair Against Chronic Gastritis: Integrating Identification of Absorbed Constituents, Targeted Network Pharmacology, and Computational Validation. [PDF]
Food Sci NutrThis work systematically explored the anti‐chronic gastritis mechanism of the FAI‐BCT herb pair. UPLC‐Q‐TOF‐MS/MS was applied to identify absorbed prototypes and metabolites of FAI‐BCT in rat plasma. Combining database mining, network pharmacology, molecular docking, and molecular dynamics simulation, we screened the key bioactive components and core ...
Ma Y, Xie W, Song J, Qin Y, Zhao Y.
europepmc +2 more sources
Phytomedicine Plus, 2022 Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes.
Tomohisa Ishikawa +2 more
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Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis [PDF]
Frontiers in PharmacologyBackground and aimBenign prostatic hyperplasia (BPH) involves androgen-driven proliferation with reduced apoptosis. Current 5α-reductase inhibitors can cause adverse effects, motivating safer options.
Jun-Hui Song +12 more
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Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions [PDF]
Discover OncologyBackground & objectives The introduction of traditional Chinese medicine to the treatment of breast cancer increases the risk of adverse herb-herb interactions.
Hongming Song +6 more
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Chemistry and bioactivity of nobiletin and its metabolites
Journal of Functional Foods, 2014 The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity ...
Chi-Tang Ho, Hui Zhao, Shiming Li
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Nobiletin Attenuates Adipogenesis and Promotes Browning in 3T3-L1 Adipocytes Through Exosomal miRNA-Mediated AMPK Activation [PDF]
Current Issues in Molecular BiologyNobiletin, a citrus-derived polymethoxylated flavone, has been reported to exert anti-obesity effects, but its molecular mechanisms remain poorly understood.
Shweta Chauhan +4 more
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Potential and Mechanism of Nobiletin in Diabetes Mellitus and Associated Complications. [PDF]
Pharmaceuticals (Basel)The incidence and mortality of diabetes have increased dramatically in recent decades. New strategies to treat diabetes and its complications with minimal side effects are urgently needed. New monomeric molecules extracted from herbs are an alternative medicine that is being explored as candidate drugs for the treatment of diabetes and its ...
Zhao C, Lai W, Li Y, Hong K, Xu Y.
europepmc +3 more sources