Results 41 to 50 of about 4,723 (202)

Nobiletin is capable of regulating certain anti-cancer pathways in a colon cancer cell line

, 2023
Natural remedies have the potential to improve conventional cancer therapies and enhance patient outcomes. Citrus polymethoxyflavone nobiletin has been demonstrated to have anticancer effects on several cancer cell lines.
Kisacam, Mehmet A.
core   +1 more source

Nobiletin Inhibits Cell Growth, Migration and Invasion, and Enhances the Anti-Cancer Effect of Gemcitabine on Pancreatic Cancer Cells

Natural Product Communications, 2021
Natural products are very promising adjuvants with a variety of biological activities. Nobiletin, a citrus polymethoxyflavone, has been shown to exert an anticancer effect in various cell lines.
Xiang Ren, Yuran Ma, Xiao Wang, Xuetao Xu, Panpan Wu, Wenfeng Liu, Kun Zhang, Susan Goodin, Dongli Li, Xi Zheng   +9 more
doaj   +1 more source

Nobiletin Increased Cytotoxic Activity Of Doxorubicin On Mcf-7 Cells But Not On T47d Cells [PDF]

, 2011
Nobiletin, a citrus flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this research was to investigate cytotoxic activities of nobiletin alone and in combination with doxorubicin.
Aditya Fitriasari, Adam Hermawan, Edy Meiyanto, Ratna Asmah Susidarti, Sendy Junedi   +4 more
core   +3 more sources

Inhibitory Effects of Metabolites of Nobiletin and 5‐hydroxy Nobiletin on Human Lung Cancer Cells

The FASEB Journal, 2012
Nobiletin (NBT) and 5‐hydroxy nobiletin (5HN) are unique polymethoxyflavones found in citrus fruits. We investigated the effects of NBT, 5HN, and their major metabolites, namely 4′‐hydroxy nobiletin (M1), 3′,4′‐dihydroxy nobiletin (M2), 3′,5‐dihydroxy nobiletin (M3), 4′,5‐dihydroxy nobiletin (M4), and 3′,4′,5‐trihydroxy nobiletin ...
Noppawat Charoensinphon, Jinkai Zheng, Ping Dong, Peiju Qiu, Thony Tran, Hang Xiao   +5 more
openaire   +1 more source

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Journal of Pharmacological Sciences, 2007
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease.
Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si-Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi   +11 more
doaj   +1 more source

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

Frontiers in Pharmacology, 2019
Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN ...
Di Wei, Geng Zhang, Zheng Zhu, Yu Zheng, Fei Yan, Chongxian Pan, Zhiyong Wang, Xian Li, Fuli Wang, Ping Meng, Wanxiang Zheng, Zhao Yan, Dongsheng Zhai, Zifan Lu, Jianlin Yuan   +14 more
doaj   +1 more source

Nobiletin Protects Endothelial Cell Function via Upregulation of eNOS/ET-1 and Antioxidant Status-Related Genes under Nonstimulated and Inflammatory Conditions

Journal of Food Quality, 2022
Nobiletin, a natural polymethoxylated flavonoid compound, has been shown to exert a wide range of biological activities. However, there is limited evidence on the molecular mechanisms by which nobiletin modulates endothelial cell function. Our aim was to
Lu Li, Biyun Zhang, Ludovica De Pieri, Yue Wu, Karen Birch, Christine Boesch   +5 more
doaj   +1 more source

Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion

Scientific Reports, 2022
The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high ...
Alexandre Martchenko, Andrew D. Biancolin, Sarah E. Martchenko, Patricia L. Brubaker   +3 more
doaj   +1 more source

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Journal of Pharmacological Sciences, 2012
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-
Tsukasa Tominari, Michiko Hirata, Chiho Matsumoto, Masaki Inada, Chisato Miyaura   +4 more
doaj   +1 more source

Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation

Scientific Reports, 2021
In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects PI3K/AKT signaling pathway.
Karina Cañón-Beltrán, Yulia N. Cajas, Serafín Peréz-Cerezales, Claudia L. V. Leal, Ekaitz Agirregoitia, Alfonso Gutierrez-Adán, Encina M. González, Dimitrios Rizos   +7 more
doaj   +1 more source