Results 41 to 50 of about 6,450 (220)
Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin
The FASEB Journal, 2013 Nobiletin (NBT), a major citrus polymethoxyflavone, has been shown to have various beneficial bioactivities such as anti‐inflammatory and anti‐carcinogenic effects. However, the in vivo absorption, metabolism, and tissue distribution of NBT is poorly understood.
Minqi Wang +4 more
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Cellular Physiology and Biochemistry, 2015 Background/Aims: Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of
Yuan Hao +3 more
doaj +1 more source
Natural Product Communications, 2021 Natural products are very promising adjuvants with a variety of biological activities. Nobiletin, a citrus polymethoxyflavone, has been shown to exert an anticancer effect in various cell lines.
Xiang Ren +9 more
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Synthetic flavonoids as novel modulators of platelet function and thrombosis [PDF]
, 2019 Cardiovascular diseases represent a major cause of mortality and morbidity in the world and thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within
Dina A. I. Albadawi +7 more
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Nöroprotektif Etkili Bir Flavonoid: Nobiletin
Harran Üniversitesi Veteriner Fakültesi Dergisi, 2017 The use of flavonoids promises new approach for the treatment of neurodegenerative diseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. The neuroprotective effect of nobiletin has been demonstrated in vivo and in vitro. Nobiletine affects the signaling cascades associated with learning and memory, ...
Gül Fatma YARIM +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2019 Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN ...
Di Wei +14 more
doaj +1 more source
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy [PDF]
Cancers, 2021 Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tackled. Thus, new treatment approaches are needed to effectively improve patient outcomes.
Alice Turdo +28 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2007 We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease.
Akira Nakajima +11 more
doaj +1 more source
Cytoprotective Effect of Tangeretin in Hydrogen Peroxyde-inducedoxydative Stress on Human Umbilical Vein Endothelial Cells (HUVECs) [PDF]
, 2015 Oxydative stress is known as a major trigger in cardiovascular dysfunction that leads to hypertension, atherosclerosis, and chronic heart failure. Polymethoxyflavone such as tangeretin and nobiletin has been reported to have biological activity including
Jenie, I. M. (Ikhlas) +3 more
core +1 more source
Journal of Food Quality, 2022 Nobiletin, a natural polymethoxylated flavonoid compound, has been shown to exert a wide range of biological activities. However, there is limited evidence on the molecular mechanisms by which nobiletin modulates endothelial cell function. Our aim was to
Lu Li +5 more
doaj +1 more source