Results 41 to 50 of about 3,745 (175)

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Journal of Pharmacological Sciences, 2012
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-
Tsukasa Tominari, Michiko Hirata, Chiho Matsumoto, Masaki Inada, Chisato Miyaura   +4 more
doaj   +1 more source

Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation

Scientific Reports, 2021
In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects PI3K/AKT signaling pathway.
Karina Cañón-Beltrán, Yulia N. Cajas, Serafín Peréz-Cerezales, Claudia L. V. Leal, Ekaitz Agirregoitia, Alfonso Gutierrez-Adán, Encina M. González, Dimitrios Rizos   +7 more
doaj   +1 more source

Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats

Journal of Pharmacy & Pharmaceutical Sciences, 2008
: PURPOSE. The objective of this study was to prepare nobiletin self-microemulsifying drug delivery systems (SMEDDS) and investigate its intestinal transport behavior using the single-pass intestinal perfusion (SPIP) method in rat. METHODS.
Jing Yao, Yun Lu, Jian Ping Zhou
doaj   +1 more source

Effect of thermosonication on the UHPLC‐QTOF‐IMS‐based metabolomic profile of orange juice

JSFA reports, EarlyView.
Abstract Background This study investigated the impact of thermosonication on the metabolomic profile of orange juice to understand processing‐induced alterations in bioactive compounds and quality attributes. Results Moderate thermosonication at 45°C preserved structural siloxanes and certain amino acids, whereas higher temperatures between 60 and 75 ...
Deepti Kothari, Arun Kumar, Saloni Joshi, Desta Dugassa Fufa, Sajad Ali   +4 more
wiley   +1 more source

Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β

International Journal of Biological Sciences, 2022
Background: Cholangiocarcinoma (CCA) is a type of hepatobiliary cancer characterized by uncontrolled cell proliferation, with a poor prognosis and high mortality. Nobiletin (NBT) is a promising anti-tumor compound derived from the peels of oranges and other citrus plants, citrus plant. But the effect of NBT on CCA remains unknown.
You, Liping, Lin, Jiacheng, Yu, Zhuo, Qian, Yihan, Bi, Yuting, Wang, Fang, Zhang, Lei, Zheng, Chao, Zhang, Jinghao, Li, Wenxuan, Cai, Yaxuan, Gao, Yueqiu, Kong, Xiaoni, Sun, Xuehua   +13 more
openaire   +2 more sources

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Nobiletin as a Neuroprotectant against NMDA Receptors: An In Silico Approach

Pharmaceutics, 2022
Excitotoxicity is a type of neurodegenerative disorder. It caused by excessive glutamate receptor activation, which leads to neuronal malfunction and fatality. The N-methyl-D-aspartate (NMDA) receptors are found in glutamatergic neurons, and their excessive activation is primarily responsible for excitotoxicity.
Sadaf Jahan, Neeru Singh Redhu, Arif Jamal Siddiqui, Danish Iqbal, Johra Khan, Saeed Banawas, Mohammed Alaidarous, Bader Alshehri, Shabir Ahmad Mir, Mohd Adnan, Aditya Bhushan Pant   +10 more
openaire   +3 more sources

Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis

Scientific Reports
Nobiletin, a citrus polymethoxy flavonoid with antiapoptotic and antioxidative properties, could safeguard against cisplatin-induced nephrotoxicity and neurotoxicity.
Wenao Song, Li Zhang, Xiaolin Cui, Rongrong Wang, Jingyu Ma, Yue Xu, Yan Jin, Dawei Wang, Zhiming Lu   +8 more
doaj   +1 more source

Metabolomics‐based study of the preservation mechanism of a tea saponin–cinnamaldehyde nanoemulsion applied to Xinyu tangerines

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background The Xinyu tangerine is a geographical indication agricultural product from Jiangxi province, China. During postharvest storage, nutrient loss and pathogen‐induced decay reduce fruit quality. The selection of appropriate preservatives is therefore important for maintaining postharvest quality.
Yan Leng, Xinjian Gao, Yichen Zhang, Zehang Yan, Wanyi Chen, Yang Huang, Xiaoxia Zuo, Liqin Zhu, Zhipeng Cai, Jing Wang, Yonggen Shen   +10 more
wiley   +1 more source

Nöroprotektif Etkili Bir Flavonoid: Nobiletin

Harran Üniversitesi Veteriner Fakültesi Dergisi, 2017
The use of flavonoids promises new approach for the treatment of neurodegenerative diseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. The neuroprotective effect of nobiletin has been demonstrated in vivo and in vitro. Nobiletine affects the signaling cascades associated with learning and memory, ...
Gül Fatma YARIM, Metin ÇENESİZ, Murat YARIM, Filiz KAZAK   +3 more
openaire   +4 more sources