Results 51 to 60 of about 6,450 (220)
Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]
, 2020 BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine +9 more
core +3 more sources
Deficit irrigation and maturation stage influence quality and flavonoid composition of ‘Valencia’ orange fruit [PDF]
, 2016 BACKGROUND:Effects of continuous deficit irrigation (DI) and partial rootzone drying (PRD) treatments (50%ETc) in comparison with full irrigation (CI, 100% ETc) were investigated during ‘Valencia’ orange fruit maturation.
DI STEFANO, Vita +2 more
core +1 more source
Molecules, 2016 Nobiletin, a major component of citrus fruits, is a polymethoxyflavone derivative that exhibits anticancer activity against several forms of cancer, including SNU-16 human gastric cancer cells.
Jeong Yong Moon, Somi Kim Cho
doaj +1 more source
Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion
Scientific Reports, 2022 The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high ...
Alexandre Martchenko +3 more
doaj +1 more source
Citrus phenylpropanoids and defence against pathogens. Part I: Metabolic profiling in elicited fruits [PDF]
, 2016 Penicillium spp. are among the major postharvest pathogens of citrus fruit. Induction of natural resistance in fruits constitutes one of the alternatives to chemical fungicides.
Ballester Frutos, Ana Rosa +4 more
core +1 more source
Inhibitory Effects of Metabolites of Nobiletin and 5‐hydroxy Nobiletin on Human Lung Cancer Cells
The FASEB Journal, 2012 Nobiletin (NBT) and 5‐hydroxy nobiletin (5HN) are unique polymethoxyflavones found in citrus fruits. We investigated the effects of NBT, 5HN, and their major metabolites, namely 4′‐hydroxy nobiletin (M1), 3′,4′‐dihydroxy nobiletin (M2), 3′,5‐dihydroxy nobiletin (M3), 4′,5‐dihydroxy nobiletin (M4), and 3′,4′,5‐trihydroxy nobiletin ...
Noppawat Charoensinphon +5 more
openaire +1 more source
Journal of Pharmacological Sciences, 2012 Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-
Tsukasa Tominari +4 more
doaj +1 more source
Scientific Reports, 2021 In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects PI3K/AKT signaling pathway.
Karina Cañón-Beltrán +7 more
doaj +1 more source
Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss [PDF]
, 2016 Excessive accumulation of fat as the result of more energy intake and less energy expenditure is known as obesity. Lipids are essential components in the human body and are vital for maintaining homeostasis and physiological as well as cellular ...
Mantso, Theodora +3 more
core +1 more source
Pharmacology Research & Perspectives, 2021 Nobiletin was found to protect against acute myocardial infarction (AMI)‐induced cardiac function decline and myocardial remodeling, although the dose–effect relationship and underlying pathways remained unclear.
Zumei Liu +5 more
doaj +1 more source