Results 51 to 60 of about 3,745 (175)

Beneficial effects of a representative flavonoid, nobiletin on cognitive and urinary dysfunctions [PDF]

BIO Web of Conferences
Citrus fruits contain flavonoids that exhibit various physiological activities. They have been utilized as fruits, foods, and supplements that may exert favorable effects on health.
Yamada Shizuo, Shirai Michiyo, Sugaya Kimio, Woo Je Tae   +3 more
doaj   +1 more source

Nobiletin with AIEE Characteristics for Targeting Mitochondria and Real-Time Dynamic Tracking in Zebrafish

Molecules, 2023
Nobiletin is a natural product with multiple physiological activities and is the main ingredient of Pericarpium Citri Reticulatae. We successfully discovered that nobiletin exhibits aggregation induced emission enhancement (AIEE) properties and it has ...
Tingting Jin, Na Li, Yi Wu, Ying He, Depo Yang, Feng He   +5 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Urinary Metabolites of Nobiletin Orally Administered to Rats

Chemical and Pharmaceutical Bulletin, 2003
During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by ...
Yasuda, Takaaki, Yoshimura, Yukako, Yabuki, Hisako, Nakazawa, Takahiro, Ohsawa, Keisuke, Mimaki, Yoshihiro, Sashida, Yutaka   +6 more
openaire   +3 more sources

Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis [PDF]

Carcinogenesis, 2017
Different cancer chemopreventive agents may act synergistically and their combination may produce enhanced protective effects against carcinogenesis than each individual agent alone. Herein, we investigated the chemopreventive effects of nobiletin (NBT, a citrus polymethoxyflavone) and atorvastatin (ATST, a lipid-lowering drug) in colon cancer cells ...
Xian, Wu, Mingyue, Song, Peiju, Qiu, Kanyasiri, Rakariyatham, Fang, Li, Zili, Gao, Xiaokun, Cai, Minqi, Wang, Fei, Xu, Jinkai, Zheng, Hang, Xiao   +10 more
openaire   +2 more sources

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

Frontiers in Pharmacology, 2019
Osteoarthritis (OA), a common degenerative joint disease, is principally characterized by inflammation and destruction of cartilage. Nobiletin, an extract of the peel of citrus fruits, is known to have anti-inflammatory properties.
Zeng Lin, Dengying Wu, Lipeng Huang, Chao Jiang, Tianlong Pan, Xiaodiao Kang, Jun Pan   +6 more
doaj   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

Effect of Nobiletin on Lipid Metabolism in Rats

Journal of Health Science, 2010
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes and improves hyperglycemia and insulin resistance in obese (ob) diabetic ob/ob mice. We investigated the effects of nobiletin on lipid metabolism and accumulation of body fat in rats.
Nagata, Eri, Ichi, Ikuyo, Kataoka, Ryoko, Matsushima, Miyuki, Adachi, Noriko, Kitamura, Yuko, Sasaki, Takao, Kojo, Shosuke   +7 more
openaire   +2 more sources

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Unraveling the Bioactive Compounds and Multi‐Target Mechanisms of the Fructus Aurantii Immaturus‐Bambusae Caulis in Taeniam Herb Pair Against Chronic Gastritis: Integrating Identification of Absorbed Constituents, Targeted Network Pharmacology, and Computational Validation

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This work systematically explored the anti‐chronic gastritis mechanism of the FAI‐BCT herb pair. UPLC‐Q‐TOF‐MS/MS was applied to identify absorbed prototypes and metabolites of FAI‐BCT in rat plasma. Combining database mining, network pharmacology, molecular docking, and molecular dynamics simulation, we screened the key bioactive components and core ...
Yinghua Ma, Weiwei Xie, Jing Song, Yabin Qin, Yile Zhao   +4 more
wiley   +1 more source