Results 71 to 80 of about 6,450 (220)

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

Nöroprotektif etkili bir flavonoid : nobiletin

, 2019
Nörodejeneratif hastalıkların tedavisinde flavonoidlerin kullanımı yeni umutlar vaad etmektedir. Nobiletin, narenciye kabuklarında bulunan bir polimetoksi flavonoiddir. Nobiletinin nöroprotektif etkiye sahip olduğu pek çok in vivo ve in vitro araştırma ile ortaya konulmuştur.
Yarım, Gül Fatma, Çenesiz, Metin, Yarım, Murat, Çenesiz, Sena, Kazak, Filiz   +4 more
openaire   +2 more sources

Beneficial effects of a representative flavonoid, nobiletin on cognitive and urinary dysfunctions [PDF]

BIO Web of Conferences
Citrus fruits contain flavonoids that exhibit various physiological activities. They have been utilized as fruits, foods, and supplements that may exert favorable effects on health.
Yamada Shizuo, Shirai Michiyo, Sugaya Kimio, Woo Je Tae   +3 more
doaj   +1 more source

Nobiletin with AIEE Characteristics for Targeting Mitochondria and Real-Time Dynamic Tracking in Zebrafish

Molecules, 2023
Nobiletin is a natural product with multiple physiological activities and is the main ingredient of Pericarpium Citri Reticulatae. We successfully discovered that nobiletin exhibits aggregation induced emission enhancement (AIEE) properties and it has ...
Tingting Jin, Na Li, Yi Wu, Ying He, Depo Yang, Feng He   +5 more
doaj   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

Frontiers in Pharmacology, 2019
Osteoarthritis (OA), a common degenerative joint disease, is principally characterized by inflammation and destruction of cartilage. Nobiletin, an extract of the peel of citrus fruits, is known to have anti-inflammatory properties.
Zeng Lin, Dengying Wu, Lipeng Huang, Chao Jiang, Tianlong Pan, Xiaodiao Kang, Jun Pan   +6 more
doaj   +1 more source

Urinary Metabolites of Nobiletin Orally Administered to Rats

Chemical and Pharmaceutical Bulletin, 2003
During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by ...
Takaaki, Yasuda, Yukako, Yoshimura, Hisako, Yabuki, Takahiro, Nakazawa, Keisuke, Ohsawa, Yoshihiro, Mimaki, Yutaka, Sashida   +6 more
openaire   +3 more sources

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer

Scientific Reports, 2021
Skin cancer is one of the most dangerous diseases, leading to massive losses and high death rates worldwide. Topical delivery of nutraceuticals is considered a suitable approach for efficient and safe treatment of skin cancer.
Mahitab Bayoumi, Mona G. Arafa, Maha Nasr, Omaima A. Sammour   +3 more
doaj   +1 more source

Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells

Pharmaceutics, 2021
The immune response in periodontal lesions is involved in the progression of periodontal disease. Therefore, it is important to find a bioactive substance that has anti-inflammatory effects in periodontal lesions. This study aimed to examine if nobiletin,
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo   +3 more
doaj   +1 more source