Results 91 to 100 of about 6,450 (220)
Experimental and Molecular Medicine, 2019 Liver injury: Citrus peel to the rescue Nobiletin, an antioxidant found in citrus peel, may protect the liver from reperfusion injury, damage following blood flow interruption.
Theodomir Dusabimana +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2011 .: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells.
Hironori Fujiwara +8 more
doaj +1 more source
Solid Dispersions as a Tool for Innovation in the Food Industry: A Path From Pharma to Food
Journal of Food Science, Volume 91, Issue 2, February 2026.ABSTRACT Solid dispersion (SD) is a technique used to improve the solubility of poorly water‐soluble compounds by dispersing them in a solid water‐friendly carrier. Current trends indicate that natural‐based alternatives are increasingly replacing synthetic carriers, benefiting the pharmaceutical industry, where they were first adopted, and paving the ...
Stephany C. de Rezende +3 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.Luteolin alleviates DSS‐induced ulcerative colitis in mice by targeting the NLRP3 inflammasome, as it shows no effect in NLRP3‐/‐ mice. It inhibits NLRP3 activation and IL‐1β secretion in macrophages by reducing ROS, mtROS and calcium levels via AMPK binding and signalling. Metabolomic changes suggest lipid metabolism involvement. Luteolin represents a
Lianxiang Luo +8 more
wiley +1 more source
Pharmaceuticals, 2018 Polymethoxyflavonoids (PMFs) are a family of the natural compounds that mainly compise nobiletin, tangeretin, heptamethoxyflavone (HMF), and tetramethoxyflavone (TMF) in citrus fruits.
Shigeru Matsumoto +9 more
doaj +1 more source
Impact of flavonoids on cellular and molecular mechanisms underlying age-related cognitive decline and neurodegeneration [PDF]
, 2018 Purpose of Review: This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.
Flanagan, Emma +3 more
core +1 more source
The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha +4 more
wiley +1 more source
Characterization and Antiproliferative Activity of Nobiletin‐Loaded Chitosan Nanoparticles
Journal of Nanomaterials, 2012 Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The
Ana G. Luque-Alcaraz +7 more
openaire +1 more source
, 1998 現在日本は高齢化社会を迎えて疾病構造が大きく変わりつつある。最近でこそ病原性大腸菌O157の問題が浮上しているが，疾病全体から見ると従来の感染症は主要な疾患ではなくなり，これに替わって自己免疫疾患，悪性腫蕩，高齢に伴う退行性の心臓及び腎臓疾患，老年性痴呆，肝硬変などが治療の難しい疾病になってきている。このような疾病構造の変化は和漢薬方剤のニーズを徐々に増やしている。方剤の効果はそれを構成する生薬の品質の優劣に係わっているが，生薬は天然物に由来するため種々の品質のものが存在し ...
伏見 裕利 +3 more
core +1 more source
Toxic Effects of Silica Nanoparticles on Zebrafish Embryos and Larvae [PDF]
, 2013 Silica nanoparticles (SiNPs) have been widely used in biomedical and biotechnological applications. Environmental exposure to nanomaterials is inevitable as they become part of our daily life.
Duan, Junchao +8 more
core +2 more sources