Results 91 to 100 of about 4,723 (202)

Antiviral Activity of Nobiletin against Chikungunya virus in vitro

, 2016
Background Chikungunya virus (CHIKV), a highly contagious re-emerging virus, is transmitted by infected mosquitoes. CHIKV is prevalent in tropical countries and is continuing to creep farther north into temperate areas. CHIKV is responsible for induction
Chi-Chen Lin, Shih-Chao Lin, Tony T Wang, Mei-Chun Chen, Shiming Li   +4 more
core   +1 more source

Nobiletin alleviates endometriosis via down-regulating NF-κB activity in endometriosis mouse model

, 2018
Nobiletin exhibits protective potential on inflammation and inhibits the activation of transcription factors nuclear factor-κB (NF-κB). However, its effects on the progression of endometriosis remain unsettled.
Xu Shao, Xin Wei
core   +1 more source

Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC-12 cells [PDF]

, 2016
Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models ...
Mimaki, Yoshihiro, Uozumi, Nobuyuki, Yokosuka, Akihito, Nakamura, Masanori, Kajima, Koji, Watanabe, Makoto, Takito, Jiro, Ohizumi, Yasushi, Kimura, Junko   +8 more
core   +1 more source

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

, 2011
OBJECTIVE Increased plasma concentrations of apolipoprotein B100 often present in patients with insulin resistance and confer increased risk for the development of atherosclerosis.
André Marette, Dawn E. Telford, Brian G. Sutherland, Cynthia G. Sawyez, Julie B. Koppes, Philippe St-Pierre, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill, Julia M. Assini, Alexandre Charbonneau, Emma M. Allister, Justin K. Lee   +12 more
core   +1 more source

Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA‐CREB pathway in oral squamous cell carcinoma

, 2020
BACKGROUND/AIM Nobiletin is a polymethoxylated flavone enriched in Citrus and is used as an important drug in traditional Chinese medicine for various kinds of diseases.
Yang, Zhao-An, Zhao‐An Yang, Ma, Yi-Ke, Tu, Cheng-Wei, Yi‐Ming Fang, Chong‐Xiang Lin, Xia Shao, Shao, Xia, Ye, Peng-Cheng, Fang, Yi-Ming, Peng‐Cheng Ye, Lin, Chong-Xiang, Yi‐Ke Ma, Cheng‐Wei Tu   +13 more
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Characterization and Antiproliferative Activity of Nobiletin‐Loaded Chitosan Nanoparticles

Journal of Nanomaterials, 2012
Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The
Ana G. Luque-Alcaraz, Jaime Lizardi, Francisco M. Goycoolea, Miguel A. Valdez, Ana L. Acosta, Simon B. Iloki-Assanga, Inocencio Higuera-Ciapara, Waldo Argüelles-Monal   +7 more
openaire   +1 more source

The Self-Assembly Soluplus Nanomicelles of Nobiletin in Aqueous Medium Based on Solid Dispersion and Their Increased Hepatoprotective Effect on APAP-Induced Acute Liver Injury

, 2023
Jinrong Ning,1,* Guodong Zheng,1,* Yi Cai,1,* Yunguang Hu,2,* Yiqi Liu,1 Enping Lai,1 Baizhong Chen,3 Yujie Liu,1 Ziqi Liang,1 Jijun Fu,1 Minyan Wei1 1Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory
Liu Y, Wei M, Hu Y, Lai E, Liang Z, Fu J, Cai Y, Ning J, Zheng G, Chen B   +9 more
core  

Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism

Molecular Medicine
The incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but effective interventions are currently unavailable.
Ni Yang, Yue-Shan Pang, Yali Zheng, Yan-Ju Gong, Wei-Jun Ding   +4 more
doaj   +1 more source

Nobiletin Prevents Trimethylamine Oxide-Induced Vascular Inflammation via Inhibition of the NF-kappa B/MAPK Pathways

, 2023
Dietary choline and its containing foods are biotransformed to trimethylamine (TMA) via gut microbial metabolism. Subsequently, as an intermediate molecule, TMA is quickly transported and oxidized in the liver by hepatic flavin monooxygenases to form ...
Chi-Chen Lin, Guliang Yang, Peilei Wang, Xiang Wen, Hui Zhao, Yiwen Yang, Shiming Li, Min-Hsiung Pan, Chi-Tang Ho, Li Yuan   +9 more
core  

Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

Scientific Reports, 2019
Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss of islets in the process of isolation and pre-transplantation due to cellular stresses-induced apoptosis.
Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Bita Geramizadeh, Elahe Motevaseli, Saman Nikeghbalian, Alireza Shamsaeefar, Nasrin Motazedian, Ismail H. Al-Abdullah, Mohammad Hossein Ghahremani, Negar Azarpira   +10 more
doaj   +1 more source