Results 111 to 120 of about 4,723 (202)

Discovery of Nobiletin from Citrus Peel as a Potent Inhibitor of β-Amyloid Peptide Toxicity

, 2019
Increasing evidence has demonstrated that amyloid-β peptide (Aβ), the hallmark of Alzheimer’s disease (AD), evokes oxidative and inflammatory cascades, which ultimately lead to the death of neurons.
Kumju Youn, Mira Jun, Seonah Lee
core   +1 more source

Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway

Molecular Medicine
Background To explore whether nobiletin has a protective effect on high-fat diet (HFD)-induced enteric nerve injury and its underlying mechanism. Methods An obesity model was induced by a HFD.
Yueshan Pang, Li Zhang, Zhuoting Zhong, Ni Yang, Yali Zheng, Weijun Ding   +5 more
doaj   +1 more source

Nobiletin acts as a potential anticancer agent against osteosarcoma by regulating ERK and AKT signaling pathways

Bangladesh Journal of Pharmacology, 2014
The current study was aimed to evaluate the anti-proliferative activity of nobiletin, a flavonoid, on osteosarcoma cell line, SaOS-2. Furthermore, we attempted to investigate the signaling pathways involved in the cell growth inhibition mechanism.
Fu-Wen Niu, Yong-Jie Zhang, Kun Li, Mao-Shu Zhang   +3 more
doaj  

Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway

Asthma is a chronic airway inflammation that is considered a serious public health concern worldwide. Nobiletin (5,6,7,8,3′,4′-hexamethyl flavonoid), an important compound isolated from several traditional Chinese medicines, especially Citri ...
Guanhua Du, Yuerun Liang, Guixin Xiong, Fang Lu, Ximing Xu, Jiejie Hao, Huicong Liang, Yan Zhang, Yaping Yang, Qi Zou, Xiaomin Zhang, Kan Yang   +11 more
core   +1 more source

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin

Discover Oncology
Breast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance.
Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio   +4 more
doaj   +1 more source

Potential role of nobiletin in Alzheimer’s disease

Journal of Food Bioactives, 2023
Huilin Fang, Lingling Zhang, Hui Zhao
openaire   +1 more source

Nobiletin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Myristoleic Acid Metabolism

Disturbance of the gut microbiota plays a critical role in the development of nonalcoholic fatty liver disease (NAFLD). Increasing evidence supports that natural products may serve as prebiotics to regulate the gut microbiota in the treatment of NAFLD ...
Ning-Ning Zhang (505747), Yang Lin (162495), Zheng-Meng Jiang (9332363), Xing Yang (262520), Tian-Qing Huang (12435347), Yongxiang Yi (9082613), Shang-Zhen Li (3703753), E-Hu Liu (332072)   +7 more
core   +1 more source

Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats

Possible protective and therapeutic effects of nobiletin on kidney in a cisplatin-induced nephrotoxicity rat model were investigated. Forty male albino rats were divided into four groups: control, cisplatin (CIS), cisplatin+nobiletin (CIS+NOB), and ...
KAZAK, FİLİZ, Ates, Mehmet Burak, Yarım, Gül Fatma, Ozdemir, Ozgur, DEVECİ, MEHMET ZEKİ YILMAZ, COŞKUN, PINAR, Baspinar, Nuri, ALTUĞ, MUHAMMED ENES   +7 more
core   +1 more source

Natural bioactive compounds targeting the macrophage clock in asthma: evidence, challenges, and perspectives. [PDF]

Front Immunol
Ni B, Chen R, Sun S, Liu Z, Zhang X, He H, Wang J.   +6 more
europepmc   +1 more source

Nobiletin Protects Endothelial Function in High-Fat Diet-Induced Obese Mice Through Activation of 5' Adenosine Monophosphate-Activated Protein Kinase. [PDF]

Nutrients
Deng Q, Wang Y, Yang Y, Miao L, Zhong C, Fu M, Cheang WS.   +6 more
europepmc   +1 more source