Neuroinflammation and Secretase Regulation in Alzheimer's Disease: From Molecular Cross-Talk to Multi-Target Therapeutics. [PDF]
Cipriano GL +6 more
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Erratum: Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells. [PDF]
Liu J +7 more
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One-step green assembly of natural polyphenol-based nobiletin nanoparticles for ulcerative colitis therapy. [PDF]
Chen X +5 more
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Potential circadian rhythm-related pathogenic genes in diabetic nephropathy: a multi-omics Mendelian randomization study. [PDF]
Mao Y +7 more
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Grapefruit By-Products as a Sustainable Source of Bioaccessible Polyphenols with In Vitro Neuroprotective Potential. [PDF]
Soriano-Romaní L +6 more
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The difference in light intensities during culture affects the production of health-beneficial metabolites in a diatom used in producing aquaculture feed. [PDF]
Takebe H, Sakurai A, Imamura S.
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Identification of nobiletin metabolites in mouse urine
Molecular Nutrition and Food Research, 2006AbstractNobiletin, a major component of citrus polymethoxyflavones, has many potential significant health benefits. While the biological activities of nobiletin have been widely reported, its in vitro and in vivo metabolic fate has been rarely studied.
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Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
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Chemistry and bioactivity of nobiletin and its metabolites
The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity ...
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Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives
Current Pharmaceutical Design, 2023Abstract: Cancer has remained to be one of the major challenges in medicine and regarded as the second leading cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug resistance mediators, which ...
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