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Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells
Biochemistry, 2005Nobiletin is a nonpeptide compound with a low molecular weight from a citrus fruit and has the activity to rescue bulbectomy-induced memory impairment. Here we describe that nobiletin itself induces neurite outgrowth in PC12D cells, a rat pheochromocytoma cell line, like NGF, and the molecular mechanism of its neurotrophic action.
Hiroyuki, Nagase +11 more
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Characteristics of nobiletin-induced effects on jejunal contractility
Fitoterapia, 2014Nobiletin, a citrus polymethoxylated flavone, exhibits multiple biological properties including anti-inflammatory, anti-carcinogenic, and anti-insulin resistance effects. The present study found that nobiletin exerted significant stimulatory effects on the contractility of isolated rat jejunal segments in all 6 different low contractile states, and ...
Yong-Jian Xiong +5 more
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Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion
Bioorganic & Medicinal Chemistry Letters, 2009Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at ...
Kazuhiro, Kunimasa +11 more
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Food Hydrocolloids, 2019
Abstract Due to the high crystallization, nobiletin was encapsulated by Ca2+-induced whey protein concentrate (WPC)-stabilized emulgels. Hydroxypropyl methylcellulose (HPMC) was used to regulate the interfacial properties of emulsions and viscoelasticity of emulgels.
Yan Hu +6 more
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Abstract Due to the high crystallization, nobiletin was encapsulated by Ca2+-induced whey protein concentrate (WPC)-stabilized emulgels. Hydroxypropyl methylcellulose (HPMC) was used to regulate the interfacial properties of emulsions and viscoelasticity of emulgels.
Yan Hu +6 more
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Nobiletin as an inducer of programmed cell death in cancer: a review
Apoptosis, 2022Cancer resistance to therapy is a big issue in cancer therapy. Tumours may develop some mechanisms to reduce the induction of cell death, thus stimulating tumour growth. Cancer cells may show a low expression and activity of tumour suppressor genes and a low response to anti-tumour immunity.
Jun Huang +4 more
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Nobiletin mitigates NAFLD via lipophagy and inflammation
Food & Function, 2022Nobiletin was found to mitigate nonalcoholic fatty liver disease by enhancing TFEB-mediated lipophagy, alleviating NLRP3 inflammasome and modulating macrophages polarization.
Xushan Yang +4 more
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How can nobiletin prevent obesity?
Expert Review of Endocrinology & Metabolism, 2011. However, elucidation of the effectiveness of flavonoid-containing foods in humans is confounded by the heterogeneity in flavonoid metabo-lism, potentially resulting in sub-therapeutic doses. In addition, the content of flavonoids in foods is variable and a considerable range exists in the bioavailability of flavonoids among human ...
Erin E Mulvihill, Murray W Huff
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Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
Biological and Pharmaceutical Bulletin, 2010 A growing body of evidence suggests that nobiletin (5,6,7,8,3',4'-hexamethoxy flavone) from the peel of citrus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated.
Deok-Bae Park +2 more
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Anti-inflammatory property of the urinary metabolites of nobiletin in mouse
Bioorganic and Medicinal Chemistry Letters, 2007Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3'- and 4'-demethylnobiletin) and di-demethylation (3',4 ...
Shiming Li +2 more
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Nobiletin: a citrus flavonoid displaying potent physiological activity
Acta Crystallographica Section C Structural Chemistry, 2016Nobiletin [systematic name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; C21H22O8] is a flavonoid found in citrus peels, and has been reported to show a wide range of physiological properties, including anti-inflammatory, anticancer and antidementia activities. We have solved the crystal structure of nobiletin, which revealed that the
Shuji, Noguchi +4 more
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