Results 161 to 170 of about 4,723 (202)
Upcycled Orange Peel Ingredients for Gastrointestinal and Cardiometabolic Health: A Scoping Review and Market Perspectives. [PDF]
NutrientsVilas-Boas AA +3 more
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Nobiletin Modulates Adipocyte-Derived Exosomal miRNA to Improve Liver Lipid Metabolism in Obese Mice. [PDF]
J Agric Food ChemLeung SY, Ho NY, Ho CT, Pan MH.
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Anti-inflammatory property of the urinary metabolites of nobiletin in mouse
Bioorganic and Medicinal Chemistry Letters, 2007Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3'- and 4'-demethylnobiletin) and di-demethylation (3',4 ...
Chung S Yang +2 more
exaly +3 more sources
A Flavonoid has Neuroprotective Effect: Nobiletin [PDF]
, 2017 The use offlavonoids promises new approach for the treatment of neurodegenerativediseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. Theneuroprotective effect of nobiletin has been demonstrated in vivo and in vitro.Nobiletine affects the signaling cascades associated with learning and memory,alleviates neurodegeneration by ...
YARIM, Gül Fatma +3 more
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AAPS PharmSciTech, 2020
Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
Siddharth S. Kesharwani +5 more
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Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
Siddharth S. Kesharwani +5 more
openaire +2 more sources
Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives
Current Pharmaceutical Design, 2023Abstract: Cancer has remained to be one of the major challenges in medicine and regarded as the second leading cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug resistance mediators, which ...
Reza, Moazamiyanfar +9 more
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Identification of nobiletin metabolites in mouse urine
Molecular Nutrition & Food Research, 2006AbstractNobiletin, a major component of citrus polymethoxyflavones, has many potential significant health benefits. While the biological activities of nobiletin have been widely reported, its in vitro and in vivo metabolic fate has been rarely studied.
Shiming, Li +4 more
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Characteristics of nobiletin-induced effects on jejunal contractility
Fitoterapia, 2014Nobiletin, a citrus polymethoxylated flavone, exhibits multiple biological properties including anti-inflammatory, anti-carcinogenic, and anti-insulin resistance effects. The present study found that nobiletin exerted significant stimulatory effects on the contractility of isolated rat jejunal segments in all 6 different low contractile states, and ...
Yong-Jian Xiong +5 more
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Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells
Biochemistry, 2005Nobiletin is a nonpeptide compound with a low molecular weight from a citrus fruit and has the activity to rescue bulbectomy-induced memory impairment. Here we describe that nobiletin itself induces neurite outgrowth in PC12D cells, a rat pheochromocytoma cell line, like NGF, and the molecular mechanism of its neurotrophic action.
Hiroyuki, Nagase +11 more
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