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Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives
Current Pharmaceutical Design, 2023Abstract: Cancer has remained to be one of the major challenges in medicine and regarded as the second leading cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug resistance mediators, which ...
Reza, Moazamiyanfar +9 more
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Nobiletin a Biologically Active Phytoconstituent: Systematic Review
Journal of Biologically Active Products from Nature, 2021Nobiletin is an abundant phytoconstituent having multiple pharmacological activities. Various citrus species like orange (Citrus sinensis), lemon (Citrus limon), grapefruit (Citrus paradisi) and ta...
Alok P Singh +3 more
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How can nobiletin prevent obesity?
Expert Review of Endocrinology & Metabolism, 2011. However, elucidation of the effectiveness of flavonoid-containing foods in humans is confounded by the heterogeneity in flavonoid metabo-lism, potentially resulting in sub-therapeutic doses. In addition, the content of flavonoids in foods is variable and a considerable range exists in the bioavailability of flavonoids among human ...
Erin E Mulvihill, Murray W Huff
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AAPS PharmSciTech, 2020
Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
Siddharth S. Kesharwani +5 more
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Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
Siddharth S. Kesharwani +5 more
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Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation
Metabolic Brain Disease, 2022This study aimed to explore the mechanism of Nobiletin attenuating Alzheimer's disease (AD) by inhibiting neuroinflammation.The expression of inflammatory cytokines and HMGB-1 in serum of AD patients were examined. Microglia (MGs) were treated with different doses of Nobiletin before LPS and Nigericin induction.
Wen, Chai +7 more
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Nobiletin: a citrus flavonoid displaying potent physiological activity
Acta Crystallographica Section C Structural Chemistry, 2016Nobiletin [systematic name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; C21H22O8] is a flavonoid found in citrus peels, and has been reported to show a wide range of physiological properties, including anti-inflammatory, anticancer and antidementia activities. We have solved the crystal structure of nobiletin, which revealed that the
Shuji, Noguchi +4 more
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Protective effects of nobiletin on cisplatin induced neurotoxicity in rats
International Journal of Neuroscience, 2021This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants and histopathology.Forty male Wistar Albino rats were divided into four groups: control, cisplatin (CIS), cisplatin + nobiletin (CIS + NOB) and ...
Filiz, Kazak +7 more
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Characteristics of nobiletin-induced effects on jejunal contractility
Fitoterapia, 2014Nobiletin, a citrus polymethoxylated flavone, exhibits multiple biological properties including anti-inflammatory, anti-carcinogenic, and anti-insulin resistance effects. The present study found that nobiletin exerted significant stimulatory effects on the contractility of isolated rat jejunal segments in all 6 different low contractile states, and ...
Yong-Jian Xiong +5 more
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Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats
Journal of Biochemical and Molecular Toxicology, 2019AbstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of ...
Mehmet Güvenç +7 more
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Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
Biological and Pharmaceutical Bulletin, 2010 A growing body of evidence suggests that nobiletin (5,6,7,8,3',4'-hexamethoxy flavone) from the peel of citrus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated.
Sung-Cherl Jung +2 more
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