Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. [PDF]
, 2019 LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging.
Hariri, Ali +5 more
core
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial [PDF]
, 2013 BACKGROUND: The purpose of this study was to assess the effect of 8-weeks ingestion of a commercialized joint pain dietary supplement (InstaflexTM Joint Support, Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function in
Beibei Luo +5 more
core +2 more sources
Studies on the antidepressant-like effect and prokinetic-like effects and the underlying mechanisms of Fructus aurantii and meranzin hydrate [PDF]
, 2016 目的：测定代表中药枳壳汤剂抗抑郁促动力(A&P)的吸收成分，初步阐明其A&P特别是抗抑郁的作用机理。 方法：1.含量测定。运用HPLC/MS/MS测定枳壳汤剂在空肠，海马和前额叶皮层吸收成分；2.急性抗抑郁疗效测试。该实验包括枳壳汤剂及其吸收成分水合橙皮内酯的急性抗抑郁疗效测试。该测试包括强迫游泳实验、旷场实验、习得性无助实验和新奇抑制实验；3.水合橙皮内酯的慢性抗抑郁疗效测试。包括强迫游泳实验和旷场实验；4.离体和在体胃肠动力实验；5.抗抑郁机制研究和抗抑郁促动力的共性机制研究 ...
柳进
core
The Production Of Flavonoids (Quercetin And Hesperetin) From Callus Culture Of Citrus Aurantifolia (Christm & Panzer) Swingle [PDF]
, 1999 The application of plant tissue culture technique for plant flavonoids production shows some promising results. However, certain limitation exist mainly because many cultures do not produce significant amount of the characteristic compounds from the ...
Siti Mahyuni,
core
Hepatoprotective effect of Nobiletin against 5-fluorouracil induce hepatotoxicity
Current Research in Pharmacology and Drug Discovery5-florouracil is a widely used anticancer/anti-metabolite drug used to treat solid tumor like colon cancer, head and neck, rectum, stomach, pancreas and breast cancer; but, it can cause hepatotoxicity by induction of apoptosis through activation of caspases enzymes and oxidative stress.
Safa A. Yahya, Nada N. Al-Shawi
openaire +3 more sources
Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway [PDF]
, 2013 Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases.
Adriano G. Rossi +18 more
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Effect of Nobiletin on Lipid Metabolism in Rats
Journal of Health Science, 2010 Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes and improves hyperglycemia and insulin resistance in obese (ob) diabetic ob/ob mice. We investigated the effects of nobiletin on lipid metabolism and accumulation of body fat in rats.
Eri Nagata +7 more
openaire +2 more sources
Scientific Reports, 2019 Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss of islets in the process of isolation and pre-transplantation due to cellular stresses-induced apoptosis.
Somayeh Keshtkar +10 more
doaj +1 more source
Nobiletin Inhibition of BK Channels [PDF]
Biophysical Journal, 2019 Liang Sun +2 more
openaire +1 more source
BiomoleculesBackground: The pathogenesis of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease is not well understood. This study investigated the roles and regulation of the claudin-1, -2, -3, and -4 isoforms in the pathogenesis of ...
Asmaa Al-Failakawi +3 more
doaj +1 more source