Results 101 to 110 of about 4,723 (202)

The Role of Claudins in the Pathogenesis of Dextran Sulfate Sodium-Induced Experimental Colitis: The Effects of Nobiletin

Biomolecules
Background: The pathogenesis of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease is not well understood. This study investigated the roles and regulation of the claudin-1, -2, -3, and -4 isoforms in the pathogenesis of ...
Asmaa Al-Failakawi, Aishah Al-Jarallah, Muddanna Rao, Islam Khan   +3 more
doaj   +1 more source

Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice

Polymethoxyflavonoids, such as nobiletin (abundant in Citrus depressa), have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-dementia effects, and are also a circadian clock modulator through retinoic acid receptor-related ...
Conn Ryan, Yu Tahara, Yuanyuan Lu, Atsushi Haraguchi, Shigenobu Shibata   +4 more
core   +1 more source

Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using [Cmim][(MeO)(H)PO] and Centrifugation

Natural Product Communications, 2019
The polymethoxyflavonoids nobiletin and tangeretin are isolated from peels of shekwasha ( Citrus depressa Hayata) and ponkan ( Citrus reticulata Blanco).
Hitomi Mizuno, Hibiki Yoshikawa, Toyonobu Usuki   +2 more
doaj   +1 more source

Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities

Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side effects on healthy tissues and cells.
Mendil, Ali Sefa, ÖZKARACA, MUSTAFA, Aygörmez, Serpil, ATİLA USLU, GÖZDE, USLU, HAMİT, ÇOBAN, TAHA ABDULKADİR   +5 more
core   +1 more source

Nobiletin Inhibition of BK Channels [PDF]

Biophysical Journal, 2019
Liang Sun, Lorie Ann Gonzalez, Frank T. Horrigan   +2 more
openaire   +1 more source

Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties

Nobiletin is a polymethoxylated flavone found in citrus peels. Thanks to its chemical structure and biological activities, nobiletin has been shown to have a positive effect on many diseases. In recent years, there has been a growing interest in research
Yıldıran, Hilal, Saban Güler, Meryem
core   +1 more source

Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats

Biotechnic & Histochemistry
We investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day ...
Filiz Kazak, Ahmet Uyar, Pinar Coskun, Turan Yaman   +3 more
openaire   +2 more sources

Tailoring of structured hydroxypropyl methylcellulose-stabilized emulsions for encapsulation of nobiletin: modification of the oil and aqueous phases

, 2018
HPMC as emulsifier inhibited the migration of nobiletin crystals. The physical stability and digestion fate of nobiletin depended on the emulsion structure.
Gege Sun, Lingling Lei, YanPing Cao, Huanle Chen, Bin Li, Yan Li   +5 more
core   +1 more source

Nobiletin Down-Regulates c‑KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells

, 2018
Nobiletin, a dietary citrus flavonoid, has been reported to possess several biological activities such as antioxidant, anti-inflammatory, and anticancer properties.
Yu-Ting Chen (1852891), Wan-Yun Gao (5373866), Jui-Hung Yen, Jui-Hung Yen (143537), Wan-Yun Gao, Pei-Yi Chen, Ming-Jiuan Wu, Pei-Yi Chen (143534), Yu-Ting Chen, Ming-Jiuan Wu (143529)   +9 more
core   +1 more source

Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of α-glucosidase and porcine pancreatic lipase in vitro

Ultrasonics Sonochemistry
To further enhance the application of nobiletin (an important active ingredient in Citrus fruits), we used ultrasonic homogenization-assisted antisolvent precipitation to create ultrafine particles of nobiletin (UPN).
Xiaonan Zhang, Yan Huang, Siyi Huang, Wenyi Xie, Wenxuan Huang, Yi Chen, Qiyuan Li, Fajian Zeng, Xiongjun Liu   +8 more
doaj   +1 more source