Results 81 to 90 of about 3,745 (175)

Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats

Biotechnic & Histochemistry
We investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day ...
Filiz Kazak, Ahmet Uyar, Pinar Coskun, Turan Yaman   +3 more
openaire   +2 more sources

Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using [Cmim][(MeO)(H)PO] and Centrifugation

Natural Product Communications, 2019
The polymethoxyflavonoids nobiletin and tangeretin are isolated from peels of shekwasha ( Citrus depressa Hayata) and ponkan ( Citrus reticulata Blanco).
Hitomi Mizuno, Hibiki Yoshikawa, Toyonobu Usuki   +2 more
doaj   +1 more source

Nobiletin Inhibition of BK Channels [PDF]

Biophysical Journal, 2019
Liang Sun, Lorie Ann Gonzalez, Frank T. Horrigan   +2 more
openaire   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway

Molecular Medicine
Background To explore whether nobiletin has a protective effect on high-fat diet (HFD)-induced enteric nerve injury and its underlying mechanism. Methods An obesity model was induced by a HFD.
Yueshan Pang, Li Zhang, Zhuoting Zhong, Ni Yang, Yali Zheng, Weijun Ding   +5 more
doaj   +1 more source

Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of α-glucosidase and porcine pancreatic lipase in vitro

Ultrasonics Sonochemistry
To further enhance the application of nobiletin (an important active ingredient in Citrus fruits), we used ultrasonic homogenization-assisted antisolvent precipitation to create ultrafine particles of nobiletin (UPN).
Xiaonan Zhang, Yan Huang, Siyi Huang, Wenyi Xie, Wenxuan Huang, Yi Chen, Qiyuan Li, Fajian Zeng, Xiongjun Liu   +8 more
doaj   +1 more source

Nobiletin acts as a potential anticancer agent against osteosarcoma by regulating ERK and AKT signaling pathways

Bangladesh Journal of Pharmacology, 2014
The current study was aimed to evaluate the anti-proliferative activity of nobiletin, a flavonoid, on osteosarcoma cell line, SaOS-2. Furthermore, we attempted to investigate the signaling pathways involved in the cell growth inhibition mechanism.
Fu-Wen Niu, Yong-Jie Zhang, Kun Li, Mao-Shu Zhang   +3 more
doaj  

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation
Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus fruits, can activate thermogenesis in the BAT of high-fat diet-induced obese mice. The activity of BAT is directly regulated by β-adrenergic stimulation.
openaire  

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin

Discover Oncology
Breast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance.
Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio   +4 more
doaj   +1 more source

Potential role of nobiletin in Alzheimer’s disease

Journal of Food Bioactives, 2023
Huilin Fang, Lingling Zhang, Hui Zhao
openaire   +1 more source