Results 81 to 90 of about 4,723 (202)

Characterization of a Caffeic Acid 8OMethyltransferase from Citrus and Its Function in Nobiletin Biosynthesis

, 2021
Nobiletin (3′,4′,5,6,7,8-hexamethoxyflavone) is a polymethoxylated flavonoid specifically accumulated in citrus fruit with numerous beneficial effects to human health.
Takehiko Shimada (746854), Lancui Zhang (1548157), Masaki Yahata, Tomoko Endo, Lancui Zhang, Takehiko Shimada, Hiroshi Fujii, Masaya Kato, Akari Nakata, Masaki Yahata (1548160), Masaya Kato (462514), Mao Seoka (11885894), Akari Nakata (11885897), Toshiyuki Kan (519034), Toshiyuki Kan, Hiroshi Fujii (289510), Terutaka Yoshioka, Tomoko Endo (5626490), Mao Seoka, Gang Ma (52569), Terutaka Yoshioka (3098025), Gang Ma   +21 more
core   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes. [PDF]

, 2018
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linkNobiletin is a fully methoxylated flavone that has demonstrated anticancer activity via multiple modes of ...
Ruparelia, K. C., Ketan Ruparelia, Tsatsakis, A. M., Androutsopoulos, V.P., Aristidis M. Tsatsakis, Surichan, Somchaiya, Arroo, R. R. J., Randolph R. Arroo, Somchaiya Surichan, Vasilis P. Androutsopoulos   +9 more
core   +1 more source

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis

Experimental and Molecular Medicine, 2019
Liver injury: Citrus peel to the rescue Nobiletin, an antioxidant found in citrus peel, may protect the liver from reperfusion injury, damage following blood flow interruption.
Theodomir Dusabimana, So Ra Kim, Hye Jung Kim, Sang Won Park, Hwajin Kim   +4 more
doaj   +1 more source

Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells

Journal of Pharmacological Sciences, 2011
.: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells.
Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni, Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi   +8 more
doaj   +1 more source

Surface Engineering of Pollen‐Derived Hierarchical Architectures: Tailoring Natural Scaffolds for Precision Medicine

Small Structures, Volume 7, Issue 7, July 2026.
Surface engineering converts pollen‐derived sporopollenin capsules into functional tools for medicine. Chemical, biological, and physical modifications give these natural carriers new properties. The modified capsules can release drugs on demand, recognize diseased tissues, and assist in diagnosis.
Qian Liu, Qianyi You, Bin Wang, Ziheng Wang, Mingzhou Zhang, Banglin Li, Guansong Wang, Zhi Xu, Jinping Wang, Hang Qian   +9 more
wiley   +1 more source

Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells [PDF]

, 2014
Background Nobiletin is a non-toxic dietary flavonoid that possesses anti-cancer properties. Nobiletin has been reported to reduce the risk of prostate cancer, but the mechanism is not well understood.
Xu, Guihua, Li, Zhaoliang, Jianchu Chen, Guihua Xu, Huang, Haizhi, Rankin, Gary O, Chen, Allen Y, Xingqian Ye, Ashley Creed, Chen, Jianchu, Zhaoliang Li, Yi Charlie Chen, Creed, Ashley, Haizhi Huang, Allen Y Chen, Chen, Yi C, Ye, Xingqian, Gary O Rankin   +17 more
core   +2 more sources

The Early Response to Urea, Nitrate, or Ammonium and Iron Resupply in Tomato Roots Highlights the Induction of FER, bHLHs, UMAMITs, and MATEs

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT Depending on the nitrogen (N) form available to roots, plants activate different transcriptional and metabolic pathways; this can consequently translate into differences in the composition and release of root exudates. To address the existing knowledge gap regarding the relationship between the availability of Iron (Fe) and different N forms ...
Arianna Lodovici, Leilei Zhang, Nicola Tomasi, Gabriella Vinci, Fabio Marroni, Barbara Piani, Fatemeh Hassanvand, Mustapha Arkoun, Luigi Lucini, Laura Zanin   +9 more
wiley   +1 more source

Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice

Pharmaceuticals, 2018
Polymethoxyflavonoids (PMFs) are a family of the natural compounds that mainly compise nobiletin, tangeretin, heptamethoxyflavone (HMF), and tetramethoxyflavone (TMF) in citrus fruits.
Shigeru Matsumoto, Tsukasa Tominari, Chiho Matsumoto, Shosei Yoshinouchi, Ryota Ichimaru, Kenta Watanabe, Michiko Hirata, Florian M. W. Grundler, Chisato Miyaura, Masaki Inada   +9 more
doaj   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source