Results 61 to 70 of about 3,745 (175)

Ameliorative Effects of Newly Developed Citrus Hybrid “Mubong” Peel Extract on Experimental Colitis and Gut Microbiota Dysbiosis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
DSS exposure induces severe colitis, causing gut dysbiosis and mucosal inflammation driven by NF‐κB activation and spikes in pathogenic bacteria, TNF‐α, and IL‐6. However, “Mubong” Peel Extract effectively disrupts this inflammatory cascade. By suppressing NF‐κB‐dependent transcriptional activity, the extract mitigates clinical symptoms like colon ...
Awraris Derbie Assefa, Sang Suk Kim, Seung‐Gab Han, YoSup Park, Jee‐Soo Park   +4 more
wiley   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer

Scientific Reports, 2021
Skin cancer is one of the most dangerous diseases, leading to massive losses and high death rates worldwide. Topical delivery of nutraceuticals is considered a suitable approach for efficient and safe treatment of skin cancer.
Mahitab Bayoumi, Mona G. Arafa, Maha Nasr, Omaima A. Sammour   +3 more
doaj   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Counterfeit Citri Reticulatae Pericarpium Identification: Multi‐Class Detection Using Vis/NIR Spectroscopy and Residual Neural Networks

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Citri Reticulatae Pericarpium (CRP) samples undergo authentic processing through natural air drying and preservation, whereas counterfeit CRP can be produced through high‐temperature treatment, chemical agents, dyeing, or acid–alkali processing. Vis/NIR spectral analysis combined with WGAN‐GP augmentation and Inception‐ResNet classification captures ...
Chao Ma, Mingkun Zhang, Jianwei Ma, Sudan Chen, Yunxia Yuan, Mingtong Du, Zhiyong Dai   +6 more
wiley   +1 more source

Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats

Journal of Biochemical and Molecular Toxicology, 2019
AbstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of ...
Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, Hüseyin Özkan, Gözde Arkalı, Akın Yakan, Şule Yurdagül Özsoy, Mesut Aksakal   +7 more
openaire   +2 more sources

Potential of Chinese Mandarin Peel and Leaf (Agricultural Byproducts) as Candidate Ingredients for Functional Foods and Feeds

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Mandarin peel (with higher contents of the key bioactive compounds hesperidin, nobiletin, and tangeretin) and leaf (with richer chemical diversity) are potential candidate ingredients for functional foods and feeds. The key bioactive compounds (hesperidin, nobiletin, and tangeretin) have optimal conditions for daily consumption, achieved through three ...
Jing Chen, Qinggui Lei, Boyong Chen, Chao Zhang, Zhijian Zeng, Guodong Chen, Zhengming Qian, Wenhao Wang   +7 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner.

PLoS ONE, 2020
The natural product nobiletin is a small molecule, widely studied with regard to its therapeutic effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown to affect circadian rhythms via their enhancement, resulting in ...
Sujeewa S Lellupitiyage Don, Kelly L Robertson, Hui-Hsien Lin, Caroline Labriola, Mary E Harrington, Stephanie R Taylor, Michelle E Farkas   +6 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source