Results 61 to 70 of about 4,723 (202)

In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury

, 2021
Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Thus, the purpose of this
Yoon-A Jeon, Sang Suk Kim, Young Jae Lee, Tae-Beom Seo   +3 more
core   +1 more source

Beneficial effects of a representative flavonoid, nobiletin on cognitive and urinary dysfunctions [PDF]

BIO Web of Conferences
Citrus fruits contain flavonoids that exhibit various physiological activities. They have been utilized as fruits, foods, and supplements that may exert favorable effects on health.
Yamada Shizuo, Shirai Michiyo, Sugaya Kimio, Woo Je Tae   +3 more
doaj   +1 more source

Nobiletin with AIEE Characteristics for Targeting Mitochondria and Real-Time Dynamic Tracking in Zebrafish

Molecules, 2023
Nobiletin is a natural product with multiple physiological activities and is the main ingredient of Pericarpium Citri Reticulatae. We successfully discovered that nobiletin exhibits aggregation induced emission enhancement (AIEE) properties and it has ...
Tingting Jin, Na Li, Yi Wu, Ying He, Depo Yang, Feng He   +5 more
doaj   +1 more source

Urinary Metabolites of Nobiletin Orally Administered to Rats

Chemical and Pharmaceutical Bulletin, 2003
During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by ...
Yasuda, Takaaki, Yoshimura, Yukako, Yabuki, Hisako, Nakazawa, Takahiro, Ohsawa, Keisuke, Mimaki, Yoshihiro, Sashida, Yutaka   +6 more
openaire   +3 more sources

Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis [PDF]

Carcinogenesis, 2017
Different cancer chemopreventive agents may act synergistically and their combination may produce enhanced protective effects against carcinogenesis than each individual agent alone. Herein, we investigated the chemopreventive effects of nobiletin (NBT, a citrus polymethoxyflavone) and atorvastatin (ATST, a lipid-lowering drug) in colon cancer cells ...
Xian, Wu, Mingyue, Song, Peiju, Qiu, Kanyasiri, Rakariyatham, Fang, Li, Zili, Gao, Xiaokun, Cai, Minqi, Wang, Fei, Xu, Jinkai, Zheng, Hang, Xiao   +10 more
openaire   +2 more sources

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

Effect of thermosonication on the UHPLC‐QTOF‐IMS‐based metabolomic profile of orange juice

JSFA reports, Volume 6, Issue 8, Page 309-313, August 2026.
Abstract Background This study investigated the impact of thermosonication on the metabolomic profile of orange juice to understand processing‐induced alterations in bioactive compounds and quality attributes. Results Moderate thermosonication at 45°C preserved structural siloxanes and certain amino acids, whereas higher temperatures between 60 and 75 ...
Deepti Kothari, Arun Kumar, Saloni Joshi, Desta Dugassa Fufa, Sajad Ali   +4 more
wiley   +1 more source

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

Frontiers in Pharmacology, 2019
Osteoarthritis (OA), a common degenerative joint disease, is principally characterized by inflammation and destruction of cartilage. Nobiletin, an extract of the peel of citrus fruits, is known to have anti-inflammatory properties.
Zeng Lin, Dengying Wu, Lipeng Huang, Chao Jiang, Tianlong Pan, Xiaodiao Kang, Jun Pan   +6 more
doaj   +1 more source

Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 8, August 2026.
This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge, MaoZe Zhang, Xujin Ning, Yijia Du, Lishuo Su, Xudong Wu, Jingyi Zhang, Tongzuo Liu, Xianliang Wang   +8 more
wiley   +1 more source

Abstract 1054: Nobiletin synergizes cytotoxicity of antimicrotubule agents by inhibiting Pin1 pathway

, 2017
Nobiletin is a citrus polymethoxy flavonoid that suppresses cell proliferation, angiogenesis and metastatic properties in various cancer cells. In this study, we investigated the combined effects of nobiletin and various chemotherapeutic agents on the ...
Masaaki Honma, Takumi Yamazaki, Kazunori Kato   +2 more
core   +1 more source