Results 31 to 40 of about 4,723 (202)

A review on recent advances on nobiletin in central and peripheral nervous system diseases

European Journal of Medical Research, 2023
In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited.
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding   +3 more
doaj   +1 more source

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

Journal of Lipid Research, 2020
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions.
Nadya M. Morrow, Amy C. Burke, Joshua P. Samsoondar, Kyle E. Seigel, Andrew Wang, Dawn E. Telford, Brian G. Sutherland, Conor O'Dwyer, Gregory R. Steinberg, Morgan D. Fullerton, Murray W. Huff   +10 more
doaj   +1 more source

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway

Frontiers in Genetics, 2022
Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance.
Senling Feng, Yongheng Zhou, Hongliang Huang, Ying Lin, Yifeng Zeng, Shanshan Han, Kaikai Huang, Quanzhi Liu, Wenting Zhu, Zhongwen Yuan, Baoying Liang   +10 more
doaj   +1 more source

Transdermal delivery of nobiletin using ionic liquids [PDF]

Scientific Reports, 2019
AbstractNobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological effects have been investigated in vitro. In the present study, we investigated the transdermal delivery of NOB using choline and geranic acid (CAGE), which is a biocompatible material that has ...
Tadashi Hattori, Hiroki Tagawa, Makoto Inai, Toshiyuki Kan, Shin-ichiro Kimura, Shigeru Itai, Samir Mitragotri, Yasunori Iwao   +7 more
openaire   +3 more sources

Anti‐inflammatory Effects of 4′‐Hydroxy Nobiletin, the Major Metabolite of Nobiletin

The FASEB Journal, 2012
Nobiletin, a citrus flavonoid has been associated with various biological activities including anti‐inflammation. We have found that 4′‐hydroxy nobiletin (4′HN) was a major colonic metabolite in mice fed with nobiletin, and the colonic levels of 4′HN were much higher than those of nobiletin.
XIAN WU, Shanshan Guo, Guang Xu, Jinkai Zheng, Hang Xiao   +4 more
openaire   +1 more source

The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway [PDF]

, 2015
Despite its importance, the death rate of ovarian cancer has remained unchanged over the past five decades, demanding an improvement in prevention and treatment of this malignancy.
KATHLEEN C. BROWN, XINGQIAN YE, Chen, Allen Y., JIANCHU CHEN, Huang, Haizhi, Dasgupta, Piyali, Chen, Yi Charlie, HAIZHI HUANG, YI CHARLIE CHEN, Brown, Kathleen C., PIYALI DASGUPTA, HALEY E. PERRY, Rojanasakul, Yon, Chen, Jianchu, Rollyson, William D., GARY O. RANKIN, Perry, Haley E., Rankin, Gary O., Ye, Xingqian, ALLEN Y. CHEN, WILLIAM D. ROLLYSON, YON ROJANASAKUL   +21 more
core   +1 more source

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Pharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang   +3 more
doaj   +1 more source

Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes

Foods, 2023
Polymethoxyflavones are flavonoids that are abundant in citrus fruit peels and have beneficial effects on human health. Previous studies have demonstrated that the polymethoxyflavones, namely sudachitin and nobiletin, ameliorate obesity and diabetes in ...
Tomoki Abe, Tomoyuki Sato, Kazutoshi Murotomi   +2 more
doaj   +1 more source

Nobiletin ameliorates streptozotocin induced diabetic retinopathy in experimental rats [PDF]

, 2014
Prolonged hyperglycemia in diabetes mellitus results in severe vascular complications leading to decrease in longevity of affected individuals. Diabetic retinopathy is a major cause of blindness in diabetes.
Parkar, Nishad, Addepalli, Veeranjaneyulu   +1 more
core   +1 more source

Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin

The FASEB Journal, 2013
Nobiletin (NBT), a major citrus polymethoxyflavone, has been shown to have various beneficial bioactivities such as anti‐inflammatory and anti‐carcinogenic effects. However, the in vivo absorption, metabolism, and tissue distribution of NBT is poorly understood.
Minqi Wang, Jinkai Zheng, Zhimei Zhong, Mingyue Song, Xian Wu   +4 more
openaire   +1 more source