Results 31 to 40 of about 3,745 (175)

The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth. [PDF]

open access: yesPLoS ONE, 2014
Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection.
Carrington J Morwood, Martha Lappas
doaj   +1 more source

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

open access: yesPharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang   +3 more
doaj   +1 more source

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

open access: yesJournal of Pharmacological Sciences, 2007
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease.
Akira Nakajima   +11 more
doaj   +1 more source

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

open access: yesFrontiers in Pharmacology, 2019
Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN ...
Di Wei   +14 more
doaj   +1 more source

Nobiletin Protects Endothelial Cell Function via Upregulation of eNOS/ET-1 and Antioxidant Status-Related Genes under Nonstimulated and Inflammatory Conditions

open access: yesJournal of Food Quality, 2022
Nobiletin, a natural polymethoxylated flavonoid compound, has been shown to exert a wide range of biological activities. However, there is limited evidence on the molecular mechanisms by which nobiletin modulates endothelial cell function. Our aim was to
Lu Li   +5 more
doaj   +1 more source

Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

open access: yesMolecules, 2016
Nobiletin, a major component of citrus fruits, is a polymethoxyflavone derivative that exhibits anticancer activity against several forms of cancer, including SNU-16 human gastric cancer cells.
Jeong Yong Moon, Somi Kim Cho
doaj   +1 more source

Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion

open access: yesScientific Reports, 2022
The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high ...
Alexandre Martchenko   +3 more
doaj   +1 more source

Protective effects of nobiletin on cisplatin induced neurotoxicity in rats

open access: yesInternational Journal of Neuroscience, 2021
This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants and histopathology.Forty male Wistar Albino rats were divided into four groups: control, cisplatin (CIS), cisplatin + nobiletin (CIS + NOB) and ...
Filiz, Kazak   +7 more
openaire   +2 more sources

Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells

open access: yesFood & Nutrition Research, 2018
Introduction: Breast cancer is one of the most commonly diagnosed cancers in women, with a high mortality rate. Objective: In the present study, we evaluated the anticancer effect of nobiletin, a flavone glycoside, on the breast cancer cell line MCF-7 ...
Jianli Liu   +7 more
doaj   +1 more source

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation

open access: yesPharmacology Research & Perspectives, 2021
Nobiletin was found to protect against acute myocardial infarction (AMI)‐induced cardiac function decline and myocardial remodeling, although the dose–effect relationship and underlying pathways remained unclear.
Zumei Liu   +5 more
doaj   +1 more source

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