Results 11 to 20 of about 4,723 (202)

Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2 [PDF]

E3S Web of Conferences, 2021
To explore the potential mechanism of nobiletin in improving the sensitivity of breast cancer MDA-MB-231 cells to Pirarubicin. MDA-MB-231 cells were randomly divided into Control group, Nobiletin group, Pirarubicin group and Nobiletin co-Pirarubicin ...
Yuan Fahu, Liao Xinghua, Zhang Tongcun
doaj   +2 more sources

Endothelium-independent vasodilator effects of nobiletin in rat aorta

Journal of Pharmacological Sciences, 2019
Nobiletin is a one of the polymethoxyflavones contained in the peel of citrus fruits, such as Citrus depressa. In this study, the effect of nobiletin-induced relaxation on phenylephrine (PE)-induced contraction of endothelium-denuded rat aorta was ...
Hisako Kaneda, Rieko Otomo, Noriyasu Sasaki, Toshinori Omi, Tsuyhoshi Sato, Takeharu Kaneda   +5 more
doaj   +2 more sources

Pharmacological actions of nobiletin in the modulation of platelet function [PDF]

British Journal of Pharmacology, 2015
Background and PurposeThe discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the antiplatelet properties of flavonoids, little is known about the mechanisms by which flavonoids inhibit platelet function. In this study, we aimed
Vaiyapuri, Sakthivel, Roweth, Harvey, Ali, Marfoua S, Unsworth, Amanda J, Stainer, Alexander R, Flora, Gagan D, Crescente, Marilena, Jones, Chris I, Moraes, Leonardo A, Gibbins, Jonathan M   +9 more
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Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis

Kaohsiung Journal of Medical Sciences, 2021
Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. However, the biological function of nobiletin in breast cancer (BC) is largely unknown.
Ji‐Guo Wang, Wen‐Jing Jian, Yang Li, Jing Zhang   +3 more
doaj   +2 more sources

Multifunctional role of Nobiletin in cancer chemoprevention.

Cellular and molecular biology (Noisy-le-Grand, France), 2022
The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers ...
Durr-E-Shahwar, Malik, Rukset, Attar, Ulku, Ozbey, Mirna Azalea, Romero, Ishmuratova Margarita, Yulaevna, Jelena, Purenovic   +5 more
core   +4 more sources

Protective effects of nobiletin on cisplatin induced neurotoxicity in rats

International Journal of Neuroscience, 2021
This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants and histopathology.Forty male Wistar Albino rats were divided into four groups: control, cisplatin (CIS), cisplatin + nobiletin (CIS + NOB) and ...
Filiz, Kazak, Pınar Peker, Akalın, Gül Fatma, Yarım, Nuri, Başpınar, Özgür, Özdemir, Mehmet Burak, Ateş, Muhammed Enes, Altuğ, Mehmet Zeki Yılmaz, Deveci   +7 more
openaire   +3 more sources

Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway

Cellular Physiology and Biochemistry, 2015
Background/Aims: Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of
Yuan Hao, Cindy S.T. Cheung, Wallace C.Y. Yip, Wing-hung Ko   +3 more
doaj   +2 more sources

Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells [PDF]

Mediators of Inflammation, 2021
Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent.
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki   +2 more
doaj   +3 more sources

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation

FASEB BioAdvances, 2023
The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu   +7 more
doaj   +3 more sources

Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats

Journal of Biochemical and Molecular Toxicology, 2019
AbstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of ...
Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, Hüseyin Özkan, Gözde Arkalı, Akın Yakan, Şule Yurdagül Özsoy, Mesut Aksakal   +7 more
openaire   +3 more sources