Results 11 to 20 of about 3,745 (175)
Mitochondrial Target of Nobiletin's Action [PDF]
Natural Product Communications, 2016 Nobiletin is an O -methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective, anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties.
Nino Sharikadze +4 more
doaj +3 more sources
Endothelium-independent vasodilator effects of nobiletin in rat aorta
Journal of Pharmacological Sciences, 2019 Nobiletin is a one of the polymethoxyflavones contained in the peel of citrus fruits, such as Citrus depressa. In this study, the effect of nobiletin-induced relaxation on phenylephrine (PE)-induced contraction of endothelium-denuded rat aorta was ...
Hisako Kaneda +5 more
doaj +3 more sources
Effect of nobiletin on experimental model of epilepsy [PDF]
Translational Neuroscience, 2018 The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
doaj +3 more sources
Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage. [PDF]
Adv Sci (Weinh)The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Su J +10 more
europepmc +2 more sources
Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation
Biological and Pharmaceutical Bulletin, 2022 Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus fruits, can activate thermogenesis in the BAT of high-fat diet-induced obese mice. The activity of BAT is directly regulated by β-adrenergic stimulation.
Kihara-Negishi, Fumiko +7 more
openaire +2 more sources
Nobiletin: A Citrus Isolate to Make Sepsis Less Sour [PDF]
Inflammation, 2016 Septic shock remains a major concern in critically ill patients. Morbidity, as reflected by cardiovascular instability and sequential organ failure, is high and mortality ranges from 20 to 50 % [1]. Treatment options are scarce and mainly causeoriented and symptomatic.
Honoré, Patrick M +4 more
openaire +3 more sources
Multifunctional role of Nobiletin in cancer chemoprevention.
Cellular and molecular biology (Noisy-le-Grand, France), 2022 The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers ...
Durr-E-Shahwar, Malik +5 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2011 Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada +6 more
doaj +1 more source
Mediators of Inflammation, 2021 Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent.
Yoshitaka Hosokawa +2 more
doaj +1 more source
Frontiers in Genetics, 2022 Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance.
Senling Feng +10 more
doaj +1 more source