Results 11 to 20 of about 6,450 (220)

Mitochondrial Target of Nobiletin's Action [PDF]

Natural Product Communications, 2016
Nobiletin is an O -methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective, anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties.
Nino Sharikadze, Natia Jojua, Maia Sepashvili, Elene Zhuravliova, David G Mikeladze   +4 more
doaj   +3 more sources

Endothelium-independent vasodilator effects of nobiletin in rat aorta

Journal of Pharmacological Sciences, 2019
Nobiletin is a one of the polymethoxyflavones contained in the peel of citrus fruits, such as Citrus depressa. In this study, the effect of nobiletin-induced relaxation on phenylephrine (PE)-induced contraction of endothelium-denuded rat aorta was ...
Hisako Kaneda, Rieko Otomo, Noriyasu Sasaki, Toshinori Omi, Tsuyhoshi Sato, Takeharu Kaneda   +5 more
doaj   +3 more sources

Pharmacological actions of nobiletin in the modulation of platelet function [PDF]

British Journal of Pharmacology, 2015
Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents.
Ali, Marfoua, Crescente, Marilena, Flora, Gagan, Gibbins, Jon, Jones, Chris, Moraes, Leo, Roweth, Harvey, Stainer, Alexander, Unsworth, Amanda, Vaiyapuri, Sakthivel   +9 more
core   +6 more sources

Effect of nobiletin on experimental model of epilepsy [PDF]

Translational Neuroscience, 2018
The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
doaj   +3 more sources

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage. [PDF]

Adv Sci (Weinh)
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Su J, Zhang S, Liang L, Bai H, Bai M, He H, Wang Y, Liu H, Liang X, Sun Y, Wu H.   +10 more
europepmc   +2 more sources

Identification of Citri Reticulatae Pericarpium (Chenpi) From Different Cultivars via LC-MS/MS and UPLC Coupled With Multivariate Chemometrics Analysis. [PDF]

Food Sci Nutr
A UPLC‐based quantitative analysis combined with multivariate chemometric methods differentiated seven Citri Reticulatae Pericarpium cultivars based on significant variations in nine flavonoids. Chemometric analysis effectively separated the seven cultivars, and hesperetin was identified as a unique marker for C. reticulata “Chachi”.
Lin D, Zhang J, Chen M, Zhong C, Cao H, Ma Z, Wu M, Zhang Y.   +7 more
europepmc   +2 more sources

Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning. [PDF]

J Cell Physiol
ABSTRACT The circadian clock orchestrates adipocyte development and lipid remodeling, with its disruption leading to the development of obesity and insulin resistance. Here we demonstrate that the flavonoid compound naringenin displays clock modulatory activity that suppresses adipocyte lipid storage while promoting browning. In adipogenic progenitors,
Xiong X, Pangemanan J, Kiperman T, Sun Z, Paul A, Yechoor V, Ma K.   +6 more
europepmc   +2 more sources

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation

Biological and Pharmaceutical Bulletin, 2022
Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus fruits, can activate thermogenesis in the BAT of high-fat diet-induced obese mice. The activity of BAT is directly regulated by β-adrenergic stimulation.
Fumiko, Kihara-Negishi, Naoki, Ohkura, Yuka, Takahashi, Toshiyuki, Fujita, Yasuhiro, Nakamura, Keiji, Maruyama, Tetsuta, Oshitari, Shinji, Yamaguchi   +7 more
openaire   +2 more sources

α-Glucosidase Inhibitory Potential of <i>Citrus reticulata</i> Peel-Derived Flavonoids-A Prelude for the Management of Type 2 Diabetes. [PDF]

Food Sci Nutr
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Baloyi IT, Rabbad AH, Gama NH, Malgas S.
europepmc   +2 more sources

Nobiletin: A Citrus Isolate to Make Sepsis Less Sour [PDF]

Inflammation, 2016
Septic shock remains a major concern in critically ill patients. Morbidity, as reflected by cardiovascular instability and sequential organ failure, is high and mortality ranges from 20 to 50 % [1]. Treatment options are scarce and mainly causeoriented and symptomatic.
Honoré, Patrick M, Jacobs, Rita, Hendrickx, Inne, De Waele, Elisabeth, Spapen, Herbert D   +4 more
openaire   +3 more sources