Results 21 to 30 of about 3,745 (175)
Anti‐inflammatory Effects of 4′‐Hydroxy Nobiletin, the Major Metabolite of Nobiletin
The FASEB Journal, 2012 Nobiletin, a citrus flavonoid has been associated with various biological activities including anti‐inflammation. We have found that 4′‐hydroxy nobiletin (4′HN) was a major colonic metabolite in mice fed with nobiletin, and the colonic levels of 4′HN were much higher than those of nobiletin.
XIAN WU +4 more
openaire +1 more source
Transdermal delivery of nobiletin using ionic liquids [PDF]
Scientific Reports, 2019 AbstractNobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological effects have been investigated in vitro. In the present study, we investigated the transdermal delivery of NOB using choline and geranic acid (CAGE), which is a biocompatible material that has ...
Tadashi Hattori +7 more
openaire +3 more sources
Pharmacological actions of nobiletin in the modulation of platelet function [PDF]
British Journal of Pharmacology, 2015 Background and PurposeThe discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the antiplatelet properties of flavonoids, little is known about the mechanisms by which flavonoids inhibit platelet function. In this study, we aimed
Vaiyapuri, Sakthivel +9 more
openaire +4 more sources
Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation
FASEB BioAdvances, 2023 The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien +7 more
doaj +1 more source
Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin
The FASEB Journal, 2013 Nobiletin (NBT), a major citrus polymethoxyflavone, has been shown to have various beneficial bioactivities such as anti‐inflammatory and anti‐carcinogenic effects. However, the in vivo absorption, metabolism, and tissue distribution of NBT is poorly understood.
Minqi Wang +4 more
openaire +1 more source
Foods, 2023 Polymethoxyflavones are flavonoids that are abundant in citrus fruit peels and have beneficial effects on human health. Previous studies have demonstrated that the polymethoxyflavones, namely sudachitin and nobiletin, ameliorate obesity and diabetes in ...
Tomoki Abe +2 more
doaj +1 more source
Potential and Mechanism of Nobiletin in Diabetes Mellitus and Associated Complications. [PDF]
Pharmaceuticals (Basel)The incidence and mortality of diabetes have increased dramatically in recent decades. New strategies to treat diabetes and its complications with minimal side effects are urgently needed. New monomeric molecules extracted from herbs are an alternative medicine that is being explored as candidate drugs for the treatment of diabetes and its ...
Zhao C, Lai W, Li Y, Hong K, Xu Y.
europepmc +3 more sources
Inhibitory Effects of Metabolites of Nobiletin and 5‐hydroxy Nobiletin on Human Lung Cancer Cells
The FASEB Journal, 2012 Nobiletin (NBT) and 5‐hydroxy nobiletin (5HN) are unique polymethoxyflavones found in citrus fruits. We investigated the effects of NBT, 5HN, and their major metabolites, namely 4′‐hydroxy nobiletin (M1), 3′,4′‐dihydroxy nobiletin (M2), 3′,5‐dihydroxy nobiletin (M3), 4′,5‐dihydroxy nobiletin (M4), and 3′,4′,5‐trihydroxy nobiletin ...
Noppawat Charoensinphon +5 more
openaire +1 more source
Natural Product Communications, 2021 Natural products are very promising adjuvants with a variety of biological activities. Nobiletin, a citrus polymethoxyflavone, has been shown to exert an anticancer effect in various cell lines.
Xiang Ren +9 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of
Yuan Hao +3 more
doaj +1 more source