Results 21 to 30 of about 6,450 (220)

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

Journal of Lipid Research, 2020
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions.
Nadya M. Morrow, Amy C. Burke, Joshua P. Samsoondar, Kyle E. Seigel, Andrew Wang, Dawn E. Telford, Brian G. Sutherland, Conor O'Dwyer, Gregory R. Steinberg, Morgan D. Fullerton, Murray W. Huff   +10 more
doaj   +1 more source

Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β

International Journal of Biological Sciences, 2022
Background: Cholangiocarcinoma (CCA) is a type of hepatobiliary cancer characterized by uncontrolled cell proliferation, with a poor prognosis and high mortality. Nobiletin (NBT) is a promising anti-tumor compound derived from the peels of oranges and other citrus plants, citrus plant. But the effect of NBT on CCA remains unknown.
You, Liping, Lin, Jiacheng, Yu, Zhuo, Qian, Yihan, Bi, Yuting, Wang, Fang, Zhang, Lei, Zheng, Chao, Zhang, Jinghao, Li, Wenxuan, Cai, Yaxuan, Gao, Yueqiu, Kong, Xiaoni, Sun, Xuehua   +13 more
openaire   +2 more sources

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Journal of Pharmacological Sciences, 2011
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Morichika Takita, Masaki Inada, Chisato Miyaura   +6 more
doaj   +1 more source

Transdermal delivery of nobiletin using ionic liquids [PDF]

Scientific Reports, 2019
AbstractNobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological effects have been investigated in vitro. In the present study, we investigated the transdermal delivery of NOB using choline and geranic acid (CAGE), which is a biocompatible material that has ...
Tadashi Hattori, Hiroki Tagawa, Makoto Inai, Toshiyuki Kan, Shin-ichiro Kimura, Shigeru Itai, Samir Mitragotri, Yasunori Iwao   +7 more
openaire   +3 more sources

Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

Mediators of Inflammation, 2021
Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent.
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki   +2 more
doaj   +1 more source

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway

Frontiers in Genetics, 2022
Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance.
Senling Feng, Yongheng Zhou, Hongliang Huang, Ying Lin, Yifeng Zeng, Shanshan Han, Kaikai Huang, Quanzhi Liu, Wenting Zhu, Zhongwen Yuan, Baoying Liang   +10 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

The impact of fruit flavonoids on memory and cognition [PDF]

, 2010
There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline.
Bhat, Haque, Jeremy P. E. Spencer, Joseph, Joseph, Joseph, Kempermann, Kuhn, Kuriyama, Spencer, Spencer   +10 more
core   +1 more source

Multifunctional role of Nobiletin in cancer chemoprevention.

Cellular and molecular biology (Noisy-le-Grand, France), 2022
The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers ...
Durr-E-Shahwar, Malik, Rukset, Attar, Ulku, Ozbey, Mirna Azalea, Romero, Ishmuratova Margarita, Yulaevna, Jelena, Purenovic   +5 more
openaire   +3 more sources

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation

FASEB BioAdvances, 2023
The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu   +7 more
doaj   +1 more source