Results 21 to 30 of about 4,723 (202)

Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis

Scientific Reports
Nobiletin, a citrus polymethoxy flavonoid with antiapoptotic and antioxidative properties, could safeguard against cisplatin-induced nephrotoxicity and neurotoxicity.
Wenao Song, Li Zhang, Xiaolin Cui, Rongrong Wang, Jingyu Ma, Yue Xu, Yan Jin, Dawei Wang, Zhiming Lu   +8 more
doaj   +2 more sources

Effect of Nobiletin on Lipid Metabolism in Rats [PDF]

Journal of Health Science, 2010
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes and improves hyperglycemia and insulin resistance in obese (ob) diabetic ob/ob mice. We investigated the effects of nobiletin on lipid metabolism and accumulation of body fat in rats.
Nagata, Eri, Ichi, Ikuyo, Kataoka, Ryoko, Matsushima, Miyuki, Adachi, Noriko, Kitamura, Yuko, Sasaki, Takao, Kojo, Shosuke   +7 more
openaire   +3 more sources

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Journal of Pharmacological Sciences, 2011
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Morichika Takita, Masaki Inada, Chisato Miyaura   +6 more
doaj   +2 more sources

The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth. [PDF]

PLoS ONE, 2014
Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection.
Carrington J Morwood, Martha Lappas
doaj   +3 more sources

Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

Molecules, 2016
Nobiletin, a major component of citrus fruits, is a polymethoxyflavone derivative that exhibits anticancer activity against several forms of cancer, including SNU-16 human gastric cancer cells.
Jeong Yong Moon, Somi Kim Cho
doaj   +2 more sources

Effect of Nobiletin on Lipid Metabolism in Rats [PDF]

Effect of Nobiletin on Lipid Metabolism in Rats
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes and improves hyperglycemia and insulin resistance in obese (ob) diabetic ob/ob mice. We investigated the effects of nobiletin on lipid metabolism and accumulation of body fat in rats.
Ichi, Ikuyo, 10139, Kataoka, Ryoko, 10140, 10138, Nagata, Eri   +5 more
openaire   +2 more sources

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation

Biological and Pharmaceutical Bulletin, 2022
Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus fruits, can activate thermogenesis in the BAT of high-fat diet-induced obese mice. The activity of BAT is directly regulated by β-adrenergic stimulation.
Kihara-Negishi, Fumiko, Ohkura, Naoki, Takahashi, Yuka, Fujita, Toshiyuki, Nakamura, Yasuhiro, Maruyama, Keiji, Oshitari, Tetsuta, Yamaguchi, Shinji   +7 more
openaire   +3 more sources

Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma

Cancer Biology & Medicine, 2021
Objective: Natural extracts, including nobiletin, have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs. However, whether and how nobiletin affects tumor growth and progression in renal cell carcinoma (RCC) are still ...
Tingting Chen, Liu Liu, Yonghong Zou, Xiaoyan Hu, Wenfeng Zhang, Tao Zhou, Xi Luo, Weihua Fu, Jie Xu   +8 more
doaj   +1 more source

Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

Scientific Reports, 2022
This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension.
Metee Iampanichakul, Anuson Poasakate, Prapassorn Potue, Siwayu Rattanakanokchai, Putcharawipa Maneesai, Parichat Prachaney, Wannapa Settheetham-Ishida, Poungrat Pakdeechote   +7 more
doaj   +1 more source

Nobiletin: A Citrus Isolate to Make Sepsis Less Sour [PDF]

Inflammation, 2016
Septic shock remains a major concern in critically ill patients. Morbidity, as reflected by cardiovascular instability and sequential organ failure, is high and mortality ranges from 20 to 50 % [1]. Treatment options are scarce and mainly causeoriented and symptomatic.
Honoré, Patrick M, Jacobs, Rita, Hendrickx, Inne, De Waele, Elisabeth, Spapen, Herbert D   +4 more
openaire   +3 more sources