Results 301 to 310 of about 1,477,713 (327)
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Chronobiology International, 2013
The circadian clock and the hypoxic signaling pathway play critical roles in physiological homeostasis as well as in tumorgenesis. Interactions between both pathways have repeatedly been reported for mammals during the last decade, the molecular basis ...
M. Egg +10 more
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The circadian clock and the hypoxic signaling pathway play critical roles in physiological homeostasis as well as in tumorgenesis. Interactions between both pathways have repeatedly been reported for mammals during the last decade, the molecular basis ...
M. Egg +10 more
semanticscholar +1 more source
The European Physical Journal B, 2010
This paper investigates the effect of integration of intracellular and extracellular signals on collective dynamics based on a multicellular system with cell-to-cell communication. Using a mathematical model of genetic repressilators coupled to quorum sensing, we show that the changes in parameters of a certain kind of cis-regulatory input function ...
Zhanjiang Yuan +4 more
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This paper investigates the effect of integration of intracellular and extracellular signals on collective dynamics based on a multicellular system with cell-to-cell communication. Using a mathematical model of genetic repressilators coupled to quorum sensing, we show that the changes in parameters of a certain kind of cis-regulatory input function ...
Zhanjiang Yuan +4 more
openaire +2 more sources
pH oscillations in cell suspensions of Dictyostelium discoideum: Their relation to cyclic-amp signals [PDF]
Journal of Cell Science, 1978 ABSTRACT Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations.
Dieter Malchow +2 more
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Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
Science, 2002Transcription of messenger RNAs (mRNAs) for Notch signaling molecules oscillates with 2-hour cycles, and this oscillation is important for coordinated somite segmentation.
Hiromi Hirata +6 more
semanticscholar +1 more source
Cell Calcium, 1991 Receptor-activated cytoplasmic Ca2+ oscillations have been investigated using both single cell microfluorometry and voltage-clamp recording of Ca(2+)-dependent Cl- current in single internally perfused acinar cells. In these cells there is direct experimental evidence showing that the ACh-evoked [Ca2+]i fluctuations are due to an inositol trisphosphate-
Ole H. Petersen +5 more
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On the effect of circadian oscillations on biochemical cell signaling by NF−κB
Journal of Theoretical Biology, 2013We report the results of a numerical investigation of a mathematical model for NF-κB oscillations, described by a set of ordinary nonlinear differential equations, when perturbed by a circadian oscillation. The main result is that a circadian rhythm, even when it represents a weak perturbation, enhances the signaling capabilities of NF-κB oscillations.
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Neuron, 1991
Intercellular Ca2+ signaling in primary cultures of glial cells was investigated with digital fluorescence video imaging. Mechanical stimulation of a single cell induced a wave of increased [Ca2+]i that was communicated to surrounding cells. This was followed by asynchronous Ca2+ oscillations in some cells.
Jean E. Merrill +3 more
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Intercellular Ca2+ signaling in primary cultures of glial cells was investigated with digital fluorescence video imaging. Mechanical stimulation of a single cell induced a wave of increased [Ca2+]i that was communicated to surrounding cells. This was followed by asynchronous Ca2+ oscillations in some cells.
Jean E. Merrill +3 more
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Spatial and temporal aspects of cellular calcium signaling
The FASEB Journal, 1996Cytosolic Ca2+ signals are often organized in complex temporal and spatial patterns, even under conditions of sustained stimulation. In this review we discuss the mechanisms and physi‐ological significance of this behavior in nonexcitable cells, in which
A. Thomas +4 more
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Cell Calcium, 1991
Receptor-activated cytoplasmic calcium (Ca2+) oscillations have been investigated in single pancreatic acinar cells by microfluorimetry (Fura-2 as indicator). At submaximal concentrations of the agonists acetylcholine (ACh) and cholecystokinin octapeptide (CCK-8), both give rise to oscillatory changes in the cytosolic free calcium concentration ([Ca2 ...
David I. Yule +2 more
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Receptor-activated cytoplasmic calcium (Ca2+) oscillations have been investigated in single pancreatic acinar cells by microfluorimetry (Fura-2 as indicator). At submaximal concentrations of the agonists acetylcholine (ACh) and cholecystokinin octapeptide (CCK-8), both give rise to oscillatory changes in the cytosolic free calcium concentration ([Ca2 ...
David I. Yule +2 more
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Modelling of simple and complex calcium oscillations
European Journal of Biochemistry, 2002This review provides a comparative overview of recent developments in the modelling of cellular calcium oscillations. A large variety of mathematical models have been developed for this wide‐spread phenomenon in intra‐ and intercellular signalling. From these, a general model is extracted that involves six types of concentration variables: inositol 1,4,
Marko Marhl +3 more
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