Results 71 to 80 of about 24,021 (264)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity

Frontiers in Immunology
BackgroundOncostatin M (OSM) is a cytokine that mediates inflammatory processes and is overexpressed in skin lesions of atopic dermatitis (AD). By amplifying neural responses to chemicals such as histamine, OSM increases sensitivity to pruritus. However,
Chie Ishikawa, Chie Ishikawa, Ryo Saito, Masataka Suehiro, Kaori Ishii, Yuhki Yanase, Tomoko Kawaguchi, Kazue Uchida, Nozomi Yanagida, Tomofumi Numata, Wataru Sasaki, Rina Kamigaki, Sachio Takeno, Akio Tanaka   +13 more
doaj   +1 more source

Social Media and Depression: Saudi Arabia

Scientific Journal of King Faisal University: Humanities and Management Sciences, 2021
The aim of this research is to investigate the effect of online social media (OSM) assimilation on individuals’ levels of depression in Saudi Arabia.
Adel Alaraifi
doaj   +1 more source

Properties of [Fe(salen)]2‐μ‐Oxo Derivatives and Their Effect on Catalytic Hydrophosphination

European Journal of Organic Chemistry, EarlyView.
A series of [Fe(salen)]2‐μ‐oxo and [Fe(salophen)]2‐μ‐oxo complexes were synthesized to probe how ligand electronics and backbone rigidity influence redox behavior and catalytic hydrophosphination of styrene. Electron‐withdrawing substituents enhance stability and activity, enabling tunable, efficient C–P bond formation.
Nathan J. Buxton, Edmund O. Dadge, Oliver S. Matys, Max A. A. Entwisle, Ruth L. Webster   +4 more
wiley   +1 more source

Race‐Based Rejection Sensitivity and Intergroup Anxiety Across the Adult Lifespan: Examining Age, Cohort, and Period Effects Among Ethnic Majority and Minority Groups

European Journal of Social Psychology, EarlyView.
ABSTRACT Intergroup interactions are often fraught with fear of rejection and intergroup anxiety—emotional reactions that undermine efforts to build inclusive societies. The current research investigates how race‐based rejection sensitivity and intergroup anxiety evolve across the adult lifespan.
Kumar Yogeeswaran, Maykel Verkuyten, Kieren J. Lilly, Jessica Gale, Danny Osborne, Fiona Kate Barlow, Chris G. Sibley   +6 more
wiley   +1 more source

Automatic Detection of Spatiotemporal Urban Expansion Patterns by Fusing OSM and Landsat Data in Kathmandu

Remote Sensing, 2019
During the last few decades, a large number of people have migrated to Kathmandu city from all parts of Nepal, resulting in rapid expansion of the city.
Nishanta Khanal, Kabir Uddin, Mir A. Matin, Karis Tenneson   +3 more
doaj   +1 more source

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes

Nature Communications
Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes.
Yi Zhou, Panayiotis E. Stevis, Jing Cao, George Ehrlich, Jennifer Jones, Ashique Rafique, Mark W. Sleeman, William C. Olson, Matthew C. Franklin   +8 more
doaj   +1 more source

Oncostatin M (OSM) cytostasis of breast tumor cells: characterization of an OSM receptor beta-specific kernel

, 2006
The interleukin-6 cytokine oncostatin M (OSM) induces potent growth-inhibitory and morphogenic responses in several different tumor cell types, highlighting the importance of OSM signaling mechanisms as targets for therapeutic intervention.
Heath, John, Underhill-Day, Nicholas, John K. Heath, Nicholas Underhill-Day   +3 more
core   +1 more source

Mapping School Accessibility in Africa: High‐Resolution Spatial Analysis Uncovers Inequalities in Education Access

Sustainable Development, EarlyView.
ABSTRACT Education is a cornerstone of sustainable development, yet large disparities in access persist across and within countries—particularly in Africa, where millions remain underserved. Among several factors influencing educational participation, physical accessibility to schools (in terms of travel time) is not comprehensively understood ...
Diana Jaramillo‐Araujo, Jim W. Hall
wiley   +1 more source