Results 111 to 120 of about 2,479,763 (143)
Environmental Toxicology, Volume 41, Issue 10, Page 849-861, October 2026.ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino +2 more
wiley +1 more source
TGF‐β1 Directly Sensitizes Capsaicin‐Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Yueh‐Yin Chen +2 more
wiley +1 more source
Clinical Endocrinology, Volume 105, Issue 4, Page 442-451, October 2026.ABSTRACT Objective The effect of transsphenoidal surgery (TSS) on the hypothalamic‐pituitary‐gonadal (HPG) axis in patients with non‐functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that ...
Victor Hantelius +6 more
wiley +1 more source
Journal of Food Safety, Volume 46, Issue 5, October 2026.Environmental stress conditioning modified the susceptibility of Salmonella Typhimurium and Listeria innocua to carvacrol and thymol. Osmotic and cold adaptation were associated with increased tolerance and faster recovery after antimicrobial exposure.
Titus Puorizaa, Veerachandra Yemmireddy
wiley +1 more source
Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester +6 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.High glucose upregulates S100A1, enhancing MDM2–KLF15 interaction and K48‐linked ubiquitination of KLF15. Degradation of KLF15 relieves ID1 repression, promoting ID1 upregulation, inflammation, fibrosis, tubular injury, and DKD progression. ABSTRACT Diabetic kidney disease (DKD) is the leading cause of end‐stage renal disease globally.
Zhitao Zeng +9 more
wiley +1 more source
Inositol pyrophosphate kinases in health and disease
FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 52, 16 September 2026.Glycogen is introduced as a metabolic battery that offers local and cell‐triggered release of glucose. Glycogen can be stably encapsulated into hydrogel (Dex‐TA) microcapsules that allow for diffusion of glycogen‐degrading enzymes and nutrients.
Melvin Gurian +8 more
wiley +1 more source