Results 121 to 130 of about 2,479,763 (143)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, Volume 13, Issue 49, 3 September 2026.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

LOW OSMOLAR ORS FOR TREATING DIARRHEA IN CHILDREN: A SYSTEMATIC REVIEW AND META-ANALYSIS

, 2015
Introduction:Dehydration is one of the main complications of diarrhea. Rationale: Standard WHO-ORS reduces dehydration, but does not reduce stool volume and duration of diarrhea. Low osmolar ORS produce maximal water absorption. Objectives:
Mihir, Rupani
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Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source

Dynamic Variability of Sodium and Potassium Predicts Mortality in Critically Ill Patients With Ischemic Stroke: Evidence From Two Critical Care Cohorts

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Ischemic stroke (IS) is one of the leading causes of death and long‐term disability worldwide. Electrolyte fluctuations, particularly in sodium and potassium, may play a critical role in the mortality of IS. Methods This retrospective cohort study utilized the MIMIC‐IV database and NWICU to examine the association between sodium and
Jian Zhang, Wei Zhang, Bin Zeng, Linfeng Xie, Jianjun Zhu   +4 more
wiley   +1 more source

The Molecular Architecture of Somatic Spines of the Lateral Septum

Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.
Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker, Erich Weisheim, Michaela Schweizer, Undine Schneeweiß, Maximilian Borgmeyer, Michael Brecht, Marina Mikhaylova   +6 more
wiley   +1 more source

Hessental (concentration camp) Collection 2000-2001

This collection contains material regarding Hessental concentration camp (near Schwäbisch Hall), including a letter from a member of a group to establish a memorial at the site, educational brochures regarding the events at Hessental, and newspaper ...
Hessental (Concentration camp) 1944-1945
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Preparation of Acute Mouse Hippocampal Brain Sections for Transport to a Distant Electrophysiology Laboratory

Current Protocols, Volume 6, Issue 9, September 2026.
Abstract This article describes a standardized method for preparing and transporting acute mouse hippocampal brain slices suitable for high‐quality single‐cell, CA1, pyramidal cells electrophysiological recordings between laboratories in departments or institutions located at distances up to 3 hr apart.
Sofia Ioanna Nouka, Loukia Katsouri, Jonathan Rudge, John O'Keefe, Francesco Tamagnini   +4 more
wiley   +1 more source

A TREK‐1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory

Glia, Volume 74, Issue 9, September 2026.
Astrocytic TREK‐1‐dependent volume transients contribute to hippocampal synaptic plasticity and memory formation. TRPA1‐mediated astrocytic calcium signaling is required for long‐term potentiation, while astrocytic BDNF is necessary and sufficient to support sustained synaptic plasticity.
Victor James Drew, Junsung Woo, Jung Moo Lee, Wuhyun Koh, Joungha Won, Jae‐Hun Lee, C. Justin Lee   +6 more
wiley   +1 more source

Navigating Human Astrocyte Differentiation: Direct and Rapid One‐Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

Glia, Volume 74, Issue 9, September 2026.
One‐step protocol enabling direct differentiation of human iPSCs into functional astrocytes within 5 weeks. Validated in > 60 lines across 10 labs. iPSC‐astrocytes support robust neuronal network development in co‐culture. ABSTRACT Astrocytes play a pivotal role in neuronal network development.
Imke M. E. Schuurmans, Annika Mordelt, Marta Guevara‐Ferrer, Katrin Linda, Denise Duineveld, Sofia Puvogel, Marina P. Hommersom, Nicky Scheefhals, Lisa Rahm, Emma Dyke, Gijs‐Jan Scholten, Caroline Knorz, Carlos Gonzalez Jimenez, Noelle van Egmond, Astrid Oudakker, Chantal Bijnagte‐Schoenmaker, Hans van Bokhoven, Wei Wei, Samuel Hofmann, Sabine Jung‐Klawitter, Sandra Mojica‐Perez, Jack Parent, Lidia Carotenuto, Sarah Weckhuysen, Nadine Maas, Ype Elgersma, Eline van de Ven, Dirk Lefeber, Anita Lygeroudi, Helga E. de Vries, Luc Jordi, Magdalini Polymenidou, Teresa Mitchell‐Garcia, Iulia Dragan, Amalia Dolga, Lot D. de Witte, Clara D. M. van Karnebeek, James Ellis, Alejandro Garanto, Nael Nadif Kasri   +39 more
wiley   +1 more source