Results 11 to 20 of about 82,802 (187)

Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae [PDF]

iMeta
The intestinal microbiota acts as a barrier against pathogen colonization, yet how specific ecological perturbations shape the evolutionary fate of invading pathogens remains unclear.
Carey Lim, Jialing Zheng, Guoxiang Cheam, Melvin Yong, Hanrong Chen, Andrew Ting, Yahua Chen, Qingqing Wang, Niranjan Nagarajan, Yunn‐Hwen Gan   +9 more
doaj   +3 more sources

A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer

Pain and Therapy, 2023
Introduction Opioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The actual use of laxatives for OIC in Japan remains unelucidated.
Takahiro Higashibata, Takaomi Kessoku, Yasuhide Morioka, Yuichi Koretaka, Hirokazu Mishima, Hidetoshi Shibahara, Yuriko Masuda, Yasushi Ichikawa, Atsushi Nakajima, Takayuki Hisanaga   +9 more
doaj   +2 more sources

The “GABAergic Brake” on the Spinal Defecation Reflex: A Proposed Neurobiological Model Explaining Clozapine‐ and Benzodiazepine‐Induced Gastrointestinal Hypomotility and Ogilvie's Syndrome [PDF]

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Synergistic “Double Brake” Model on the Spinal Defecation Center in Clozapine‐Induced Constipation. Real‐world data shows BZDRs increase laxative risk in schizophrenia. Mitigating the central GABAergic brake via sedative optimization and maintaining gut microbiota homeostasis prevents fatal Ogilvie's syndrome.
Takahiko Nagamine
wiley   +2 more sources

Constipation outcomes in children with and without autism spectrum disorder: Insights from a tertiary motility service [PDF]

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 3, Page 431-437, September 2026.
Abstract Objectives Autism spectrum disorder (ASD) is commonly associated with gastrointestinal comorbidities, particularly chronic constipation. Despite high clinical burden and frequent tertiary referrals, comparative data describing clinical characteristics, management and outcomes between children with and without ASD—and across ASD severity levels—
Umair Khalid, Rishi Bolia, Joshua Bunt, Ray Lang, Nikhil Thapar   +4 more
wiley   +2 more sources

Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol [PDF]

Journal of Cystic Fibrosis, 2023
Cystic Fibrosis (CF) is a genetic disease affecting multiple organs, primarily the lungs and digestive system. Improved pulmonary management significantly improved life expectancy of CF patients. As a result, extrapulmonary manifestations, including gastrointestinal and liver-related symptoms, have become more relevant.
Anna Bertolini, Vincent W. Bloks, Marijn Wilmink, Eline Bos, Ivo P. van de Peppel, Roos Eilers, Sake Prins, Rachel Thomas, Alain de Bruin, Henkjan Verkade, Johan W. Jonker   +10 more
core   +6 more sources

Weaning Strategies for Osmotic Laxatives in Children: Navigating Knowledge Gaps and Future Directions [PDF]

Translational Pediatrics
Xiang, Gaofei, Li, Guiping
exaly   +4 more sources

Colonic Explosion During Argon Plasma Coagulation: A Systematic Review of Risk Factors, Prevention, and Management [PDF]

JGH Open, Volume 10, Issue 11, November 2026.
ABSTRACT Introduction Argon plasma coagulation (APC) is a non‐contact electrocoagulation technique widely used for hemostasis in gastrointestinal endoscopy. Despite its safety, rare but catastrophic complications such as colonic explosions have been reported.
Fariha Hasan, Ayesha Liaquat, Ishan Bhalgat, Ahmer Khan, Hareesha Rishab Bharadwaj, Dushyant Singh Dahiya, Shahryar Khan, Christina Tofani, Apeksha Shah, Anthony Infantolino   +9 more
wiley   +2 more sources

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients [PDF]

Hemodialysis International, Volume 30, Issue 4, Page 689-697, October 2026.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +2 more sources

Real-world evidence of constipation and laxative use in the Korean population with chronic kidney disease from a common data model

Scientific Reports
Constipation is a highly prevalent gastrointestinal disorder in patients with chronic kidney disease (CKD). However, our understanding of its epidemiology and management in CKD is limited.
Kipyo Kim, Ji-Eun Kim, Jae Ho Kim, Seong Hee Ahn, Chai Young Jung, Seun Deuk Hwang, Seoung Woo Lee, Joon Ho Song   +7 more
doaj   +2 more sources

Gastrointestinal adverse effects of GLP‐1 receptor agonists and dual GIP/GLP‐1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents [PDF]

Nutrition in Clinical Practice, Volume 41, Issue 5, Page 1318-1333, October 2026.
Abstract Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 receptor agonists have transformed the management of type 2 diabetes and obesity. Gastrointestinal (GI) adverse events are the most common limitation of these therapies and a leading cause of discontinuation ...
Vikash Singhani, Muhammad Ehsan, Sara Valencia, Ahmed Nadeem, Eisha Moazzam, Winfield Scott Butsch, Samita Garg   +6 more
wiley   +2 more sources