Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial [PDF]
Frontiers in PharmacologyBackgroundLaxatives are among the most commonly used pharmacological agents worldwide. Available data indicate a significant potential for clinically relevant drug-drug interactions.
Matthias Weiss-Tessbach +9 more
doaj +3 more sources
Osmotic laxative versus stimulant laxative in the management of childhood functional constipation
Advanced Medical Journal, 2023 Background and objectives: Constipation within children is an extremely common problem. The objective of this study is to evaluate and compare the efficacy and safety of osmotic and stimulant laxative used to treat functional constipation in children.
Areen Sarteep Fattah +1 more
doaj +2 more sources
Osmotic and stimulant laxatives for the management of childhood constipation [PDF]
Gastroenterology, 2016 Background Constipation within childhood is an extremely common problem. Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality ...
Akobeng, Anthony +4 more
core +6 more sources
OSMOTIC LAXATIVES IN TREATMENT OF CHRONIC CONSTIPATIONS IN CHILDREN
Вопросы современной педиатрии, 2012 A comparative trial including 80 patients at the age of 1–16 years old was performed in order to evaluate efficacy and safety of osmotic laxatives polyethylene glycol with molecular mass of 4000 kDa and lactulose (46 children received polyethylene glycol,
E. A. Kornienko +3 more
doaj +3 more sources
Weaning strategies for osmotic laxatives in children with functional constipation: a pilot multicenter randomized controlled trial. [PDF]
Transl PediatrLong-term maintenance of laxatives is crucial for treating functional constipation (FC) in children. This study aimed to compare the success rates of discontinuation based on different drug reduction methods, in order to identify the optimal strategy for discontinuing laxative use.This open-label randomized controlled trial was conducted from September
Lee YM, Kim JY, Lee KJ.
europepmc +3 more sources
Вопросы современной педиатрии, 2013 Aim: to assess clinical efficacy of polietilenglicol (macrogol) with molecular weight 4000 kDa in children with chronic constipation. Patients and methods: clinical efficacy was assessed in 30 children aged 2–12 years with chronic constipation.
A. V. Eremeeva
doaj +3 more sources
Oral Lactulose-Induced Intussusception: A Rare Complication of Juvenile Colonic Polyp [PDF]
Case Reports in GastroenterologyIntroduction: As an osmotic laxative, lactulose offers superior palatability and comparable bowel-cleansing efficacy to PEG, making it suitable for resource-limited settings, but its hypertonicity may potentially increase the risk of ...
Haizhi Tan +3 more
doaj +2 more sources
Weaning strategies for osmotic laxatives in children: navigating knowledge gaps and future directions. [PDF]
Transl PediatrXiang G, Li G.
europepmc +2 more sources
Prunus domestica as effective and acceptable treatment for stool softening and relief of constipation symptoms [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2021 Constipation, a worldwide gastrointestinal disorder needs to osmotic and stimulant laxatives. The use of herbal medicines as laxative agents is prevalent in folk and traditional medicines. Prunus L. and especially P.
Mohaddese Mahboubi
doaj +1 more source
An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance [PDF]
mSphere, 2021 AbstractAntibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the microbiota. However, non-antibiotic medications such as the ubiquitous osmotic laxative polyethylene glycol (PEG) 3350 also alter the microbiota. Clinicians also hypothesize that PEG helps clear C. difficile. But whether PEG impacts
Sarah Tomkovich +9 more
openaire +3 more sources