Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial [PDF]
Frontiers in PharmacologyBackgroundLaxatives are among the most commonly used pharmacological agents worldwide. Available data indicate a significant potential for clinically relevant drug-drug interactions.
Bernd Jilma +2 more
exaly +6 more sources
The treatment of constipation with herbal laxatives [PDF]
Arhiv za farmaciju, 2014 Constipation is usual health problem that affects about a quarter of the population. Treatment of constipation remains a challenge because of multiple, multifaceted aetiology and individual response of each patient.
Nedeljković Katarina +1 more
doaj +4 more sources
Oral absorption of high molecular weight polyethylene glycols: mechanistic, safety and regulatory insights [PDF]
Frontiers in Drug Safety and RegulationThe gastrointestinal absorption of macromolecules represents a major challenge in both drug development and regulatory evaluation, as the intestinal barrier is highly effective in limiting the systemic uptake of large molecules.
Chiara G. M. Gennari +3 more
doaj +2 more sources
Acupuncture-related therapies for opioid-induced constipation in patients with cancer: a systematic review and network meta-analysis [PDF]
Frontiers in MedicineObjectivesTo evaluate the efficacy and safety of acupuncture-related therapies for opioid-induced constipation (OIC) in patients with cancer through pairwise and network meta-analysis (NMA).MethodsWe searched eight electronic databases from inception to ...
Xinkun Liu +12 more
doaj +2 more sources
Osmotic laxative versus stimulant laxative in the management of childhood functional constipation
Advanced Medical Journal, 2023 Background and objectives: Constipation within children is an extremely common problem. The objective of this study is to evaluate and compare the efficacy and safety of osmotic and stimulant laxative used to treat functional constipation in children.
Areen Sarteep Fattah +1 more
doaj +1 more source
Prunus domestica as effective and acceptable treatment for stool softening and relief of constipation symptoms [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2021 Constipation, a worldwide gastrointestinal disorder needs to osmotic and stimulant laxatives. The use of herbal medicines as laxative agents is prevalent in folk and traditional medicines. Prunus L. and especially P.
Mohaddese Mahboubi
doaj +1 more source
BMC Geriatrics, 2023 Background Constipation was associated with incidence of dementia and cognitive decline. Laxatives are the mainstay of constipation management and are commonly used among older populations for both treatment and prevention of constipation.
Jiangtao Feng +6 more
doaj +1 more source
Diagnosis and Treatment of Elderly and Senile Chronic Constipation: an Expert Consensus
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2021 Aim. An appraisal of practitioners with chronic constipation management details in older and senile adults.Key points. Chronic constipation is a common issue in geriatrics.
V. T. Ivashkin +11 more
doaj +1 more source
Pain and Therapy, 2023 Introduction Opioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The actual use of laxatives for OIC in Japan remains unelucidated.
Takahiro Higashibata +9 more
doaj +1 more source
Chronic constipation in the practice of a therapist: Features of therapy for comorbidity [PDF]
Терапевтический архив, 2017 Aim. To evaluate the clinical efficacy of laxatives with different pharmacological effects in the combination therapy in patients with chronic constipation (CC) concurrent with obesity, hypertensive disease, and type 2 diabetes mellitus (DM).
A A Svistunov +3 more
doaj +1 more source