Results 171 to 180 of about 9,128,136 (251)

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Mechanistic insights into water transport in electrified desalination: Osmosis and electroosmosis decoupled. [PDF]

Sci Adv
Xu L, Wang Z, Elimelech M, Wang L.
europepmc   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Synergistic effects of temperature and salt stress on seed germination and the antioxidant enzyme system of okra. [PDF]

Front Plant Sci
Han G, Hu Z, Zhao Z, Zhu B, Chen J.
europepmc   +1 more source

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

Advanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen, Jia‐Hua Wang, Ching Chen, Shih‐Hsuan Fu, Rajan Deepan Chakravarthy, Hsin‐Chieh Lin   +5 more
wiley   +1 more source

Modelling vasopressin synthesis and storage dynamics during prolonged osmotic challenge and recovery based on activity dependent upregulation of mRNA transcription. [PDF]

PLoS Comput Biol
MacGregor DJ.
europepmc   +1 more source

Long‐Lifespan Polyorganosiloxane‐Based Silicone Evaporator for High‐Efficiency Seawater Desalination

Advanced Science, EarlyView.
Conventional evaporators suffer from salt crystallization and degradation. We design a white polyorganosiloxane evaporator with a reflector, achieving 4.344 kg m−2 h−1 at 1 sun in 3.5 wt.% NaCl. It shows over 53‑day cycling stability and 197‑day seawater resistance.
Jiaxian Zheng, Liqiang Zhang, Haoqi Ni, Shuozhen Chen, Xiangfeng Lin, Liwei Wang, Zhanhui Yuan   +6 more
wiley   +1 more source

Molecular-level D-A interaction engineering for high-efficiency photoelectric nanofluidic ion transport. [PDF]

Sci Adv
Chang JN, Zhu G, Zheng Q, Wang H, Chen Y, Wang C.   +5 more
europepmc   +1 more source

Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules

Advanced Science, EarlyView.
An architecture‐guided recycling process enables selective metal recovery from end‐of‐life perovskite solar modules by exploiting interfacial accessibility and calcination‐induced phase transformation. The process achieves >99.8% Pb removal, >99.7% In recovery, and >96.1% Cu recovery, while selectively retaining Sn in leaching residue.
Guang Hu, Zhaoyang Li, Shifa Zhou, Jie Qin, Sha Liang, Huabo Duan, Liang Huang, Jingping Hu, Huijie Hou, Hongjie Zhou, Ling Xu, Chao Chen, Jiang Tang, Jiakuan Yang   +13 more
wiley   +1 more source