Results 81 to 90 of about 124,083 (308)

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Post-traumatic patellar tendon ossification in children: a case series [PDF]

Travmatologiâ i Ortopediâ Rossii
Background. Fractures of the bones that form the knee joint in children are quite rare, accounting for up to 6% of all bone fractures. These include avulsion fractures of the patellar apex as well as tibial tuberosity avulsion fractures, which may result
Kirill A. Kartavenko, Vyacheslav I. Zorin, Sergey A. Lukyanov   +2 more
doaj   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Cutoff Age and Gender Difference for Various Schmeling’s Staging System of Clavicular Ossification.

Journal of Rawalpindi Medical College, 2015
Background: To determine the cut-off ages and its gender differences for various Schmeling’s staging system of clavicular ossification in population of Karachi. Methods: In this cross sectional study non probability, purposive sampling technique was used
Khurshid Nadir
doaj  

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Homozygous Achondroplasia With Long‐Term Survival: Growth Patterns, Medical Interventions, and Practice Implications

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Homozygous achondroplasia is widely considered perinatal lethal by the medical community. In this case series, we report two children from a single family with longer‐term survival. One child lived for 17 months and the other was 60 months at the time of publication.
Hannah Singerline, Jason Laufman, Kimberly Wallis, Michelle Merrill   +3 more
wiley   +1 more source

Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease [PDF]

, 2016
Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or ...
Acheson, Acheson, Adler, Allen, Anderson, Arie, Atsumi, Bahmanyar, Barker, Beals, Berg, Bergmann, Bergmann, Bergmann, Bohr, Brown, Bull, Burwell, Burwell, Caffey, Calvé, Camargo, Cameron, Canavese, Cannon, Catterall, Catterall, Choo, Chung, Churchill, Coyle, Crock, Currey, Danforth, Delclaux, Dillman, Donohue, Douglass, Duff, Ebong, Eckerwall, Edvardsen, Eijer, Eijer, Emr, Ezoe, Faraj, Fisher, García Mata, Gaskin, Gautier, Girdany, Goff, Gordon, Gray, Grzegorzewski, Guembecker, Güngör, Hailer, Hall, Hall, Hall, Hall, Hall, Hall, Harrison, Harrison, Harrison, Herndon, Herring, Herring, Hirano, Hofstaetter, Hong, Inoue, Isaac, Iwasaki, Joseph, Joseph, Joseph, Joseph, Kallio, Kamegaya, Kandzierski, Kataoka, Katz, Katz, Kawahara, Kawahara, Kealey, Kealey, Kemp, Kenet, Kim, Kim, Kim, Kim, Kitoh, Koob, Kristmundsdottir, Kristmundsdottir, Kristmundsdottir, Krul, Lappin, Laron, Larson, Lauritzen, Lee, Legg, Ljunggren, Lloyd-Roberts, Loder, Loder, Lubovsky, Madan, Margetts, McQuade, Mickelson, Moberg, Molloy, Moseley, Moulton, Nelitz, O'Higgins, Ogden, Osman, Osorio, Park, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perthes, Pillai, Pringle, Purry, Rab, Ralston, Rao, Rayfield, Rayner, Reynolds, Richmond, Rowe, Ruff, Salmaso, Salmingo, Salter, Sankar, Sharma, Shore, Smedley, Smith, Stuart, Stulberg, Suehiro, Suehiro, Tanner, Tardieu, Tardieu, Terjesen, Thompson, Thompson, Théron, Tomita, Toogood, Trueta, Tucker, Tutt, Ueo, Upadhyay, Upadhyay, Vasseur, Vaverka, Vila-Verde, Vosmaer, Wang, Weiner, Wiig, Wiig, Wijesekera, Winkleby, Wright, Wynne-Davies, Yoshida, Zarco, Zhang   +191 more
core   +2 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Biomechanics of foetal movement. [PDF]

, 2015
© 2015, AO Research Institute. All rights reserved.Foetal movements commence at seven weeks of gestation, with the foetal movement repertoire including twitches, whole body movements, stretches, isolated limb movements, breathing movements, head and neck
Nowlan, NC
core   +2 more sources