Results 91 to 100 of about 302,871 (285)

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

Frontiers in Immunology
Virus-specific CD4+ T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV).
Valerie Plajer, Valerie Plajer, Adrián Madrigal-Avilés, Adrián Madrigal-Avilés, Maria Dzamukova, Maria Dzamukova, Nayar Durán-Hernández, Nayar Durán-Hernández, Philippe Saikali, Philippe Saikali, Vivien Holecska, Vivien Holecska, Isabel Panse, Isabel Panse, Katrin Lehmann, Jinfang Zhu, Mir-Farzin Mashreghi, Mir-Farzin Mashreghi, Ahmed N. Hegazy, Ahmed N. Hegazy, Caroline Peine, Caroline Peine, Max Löhning, Max Löhning   +23 more
doaj   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Will o’ the wisp: CCN4 as a novel molecular target in osteoarthritis [PDF]

, 2010
Andrew Leask
openalex   +1 more source

4-Octyl itaconate treatment inhibits mitochondrial dysfunction and ER stress via stimulating SIRT1 expression in vitro and attenuates osteoarthritis process in murine DMM model in vivo

, 2023
Ziping Yu, Zhao Zhang, Xuancheng Zhang, Junduo Bao, Hualin Li, Jiapei Yu, Ning Shi, Fulong Nan, Liang Cao, Cheng‐Hui Li, Wei Wang   +10 more
openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Anxiety and depression prevalence and associated factors in patients with knee osteoarthritis

Frontiers in Psychiatry
ObjectiveWith the evolving spectrum of diseases, psychological conditions such as anxiety and depression have emerged as significant global public health concerns.
Qizhen Feng, Qizhen Feng, Mingjie Weng, Xi Yang, Min Zhang   +4 more
doaj   +1 more source

Synovial Fluid Biomarkers in Knee Osteoarthritis Change with Progression of Radiographic Severity [PDF]

, 2021
Matthew T. Kingery, Darryl Whitney, David S. Klein, Tiffany Rodriguez, Lena Kenny, Eric J. Strauss   +5 more
openalex   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

Osteoarthritis [PDF]

BMJ, 1950
openaire   +2 more sources