Results 71 to 80 of about 462,319 (292)

Moderators of the Effects of Exercise and Manual Therapy for People With Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate potential moderators influencing the effects of manual therapy and exercise therapy on pain and functional outcomes in individuals with knee and/or hip osteoarthritis, using data from the MOA trial. This is a secondary analysis of data from the MOA trial that compares the clinical effectiveness of manual ...
Daniel Cury Ribeiro, Sarah E. Lamb, J. Haxby Abbott   +2 more
wiley   +1 more source

A randomized controlled trial of teriparatide for accelerating bone union and improving clinical outcomes in patients with pertrochanteric fracture fixation

Scientific Reports
This prospective, double-blind, placebo-controlled, randomized trial evaluated the effects of teriparatide following pertrochanteric fracture fixation on bone healing and clinical outcomes.
Chotetawan Tanavalee, Srihatach Ngarmukos, Chavarin Amarase, Saran Tantavisut, Nonn Jaruthien, Aree Tanavalee   +5 more
doaj   +1 more source

RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Nature Communications, 2019
Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects ...
Young-Ok Son, Hyo-Eun Kim, Wan-Su Choi, Churl-Hong Chun, Jang-Soo Chun   +4 more
doaj   +1 more source

Playing sport injured is associated with osteoarthritis, joint pain and worse health-related quality of life: a cross-sectional study

BMC Musculoskeletal Disorders, 2020
Background Sports participants are faced with the decision to continue or cease play when injured. The implications of playing sport while injured on joint health and health-related quality of life (HRQoL) has not been investigated.
Garrett S. Bullock, Gary S. Collins, Nick Peirce, Nigel K. Arden, Stephanie R. Filbay   +4 more
doaj   +1 more source

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Nature Communications, 2022
The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of ...
Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning   +10 more
doaj   +1 more source

Minimal Important Change and Minimal Clinically Important Difference in Pain and Function With Exercise in Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to estimate the minimal important change (MIC) and minimal clinically important difference (MCID) for pain and physical function in individuals with hip osteoarthritis (OA) following a physiotherapist‐guided exercise intervention.
Yareni Guerrero, Fiona Dobson, Venkatesha Venkatesha, Kim Allison, Gabrielle Knox, Libby Spiers, Travis Haber, David J Hunter, Michelle Hall   +8 more
wiley   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Journal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen   +7 more
doaj   +1 more source

Physical Activity Minimum Threshold Predicting Improved Function in Adults With Lower‐Extremity Symptoms [PDF]

, 2017
Objective To identify an evidence‐based minimum physical activity threshold to predict improved or sustained high function for adults with lower‐extremity joint symptoms.
Ainsworth, Barbara, Chang, Rowland W., Dunlop, Dorothy D., Ehrlich-Jones, Linda S., Gilbert, Abigail L., Lee, Jungwha, Pellegrini, Christine A., Pinto, Daniel, Semanik, Pamela A., Song, Jing   +9 more
core   +1 more source

Formal and informal social care in people with Rheumatic and Musculoskeletal diseases: a cross‐sectional multicentre survey

Arthritis Care &Research, Accepted Article.
Introduction Rheumatic and musculoskeletal diseases(RMDs) are leading causes of physical disability, necessitating support with activities of daily living(ADLs). This study describes social care received by patients with RMDs in two disperate regions of England: Salford(urban) and Norfolk(rural).
Mehreen Somro, Karen Durrant, William G Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H Humphreys   +6 more
wiley   +1 more source

Prediction of time to prosthesis implantation as a function of joint anatomy in patients with developmental dysplasia of the hip [PDF]

, 2019
BACKGROUND: Developmental dysplasia of the hip (DDH) can lead to pain and premature secondary osteoarthritis at an early stage. Joint-preserving osteotomy is an established solution to this problem.
Müller, Michael, Perka, Carsten, Rakow, Anasthasia, Wassilew, Georgi I., Winkler, Tobias   +4 more
core   +1 more source