Results 91 to 100 of about 313,441 (304)

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

A National public health agenda for osteoarthritis : 2020 update [PDF]

Recognizing the high prevalence of OA and its rising health impact and economic consequences, the Centers for Disease Control and Prevention (CDC) and the Arthritis Foundation (AF) collaborated with other partners on A National Public Health Agenda for ...

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Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis : results of a case–control study [PDF]

, 2014
Introduction: Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC ...
Sally Doherty, Weiya Zhang, Zhang, W, Abhishek, Abhishek, Valdes, A M, Maciewicz, Rose A., Muir, Kenneth, Anna M Valdes, Maciewicz, R, Doherty, M, Abhishek, A, Doherty, S, Muir, K; id_orcid, Valdes, Ana M., Doherty, Sally A., Rose Maciewicz, Kenneth Muir, Michael Doherty, Doherty, Sally, Abhishek Abhishek, Zhang, Weiya, Maciewicz, Rose, Doherty, Michael, Valdes, Anna M   +23 more
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In Vitro Models and Proteomics in Osteoarthritis Research [Elektronisk resurs]

, 2023
This review summarizes and exemplifies the current understanding of osteoarthritis in vitro models and describes their relevance for new insights in the future of osteoarthritis research. Our friend and highly appreciated colleague, Prof. Alan Grodzinsky
Rydén, Martin,, Lund University., Önnerfjord, Patrik,   +2 more
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GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Large scale replication study of the association between HLA II/BTNL2 variants and osteoarthritis of the knee in European-descent populations [PDF]

, 2011
Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and ...
Spector Tim D., Tamm, A, Rose A Maciewicz, Maciewicz Rose A., Hart, DJ, Doherty Michael, Ana M. Valdes, Jonsson, Helgi, Mangino, M, Morris, David L., Morris, DL, Zhang Weiya, Arden, Nigel, Tamm Agu, Jonsson, Gudbjorn F, Ingvarsson Thorvaldur, Unnur Styrkarsdottir, Doherty, Sally A., David L Morris, Stefansson Kari, Kerna, I, Zhang, Weiya, Hart Deborah J., Ana M Valdes, Thorvaldur Ingvarsson, Mangino, M., Tamm Ann, Arden, N., Agu Tamm, Cooper Cyrus, Tim D Spector, Muir Kenneth R., Wheeler, M., Vyse, T.J., Stefansson, Kari, Gudbjorn F Jonsson, Metrustry, S, Sarah Metrustry, Margaret Wheeler, Arden, N.K., Helgi Jonsson, Valdes, A.M., Vyse Timothy J., Muir, KR, Sally A Doherty, Mangino Massimo, Kerna Irina, Spector, T. D., Hart, Deborah J, Arden, Nigel K., Ingvarsson, T, Tamm, Ann, Wheeler, M, Jonsson, H, Timothy J. Vyse, Morris, David L, Kisand Kalle, Ann Tamm, Vyse, Timothy J., Stefansson, K, Dennison Elaine M., Arden, NK, Metrustry, Sarah, Jonsson Helgi, Zhang, W, Tamm, Agu, Morris, D.L., Maciewicz, RA, Cooper, C., Spector, Tim D., Wheeler, Margaret, Kari Stefansson, Ingvarsson, T., Valdes Ana M., Timothy J Vyse, Muir, Kenneth R, Dennison, E.M., Elaine M Dennison, Cooper, C, Doherty, M., Spector, Tim D, Morris David L., Elaine M. Dennison, Hart, D.J., Hart, Deborah J.; id_orcid, Doherty, Michael, Muir, K.R., Metrustry Sarah, Styrkarsdottir Unnur, Vyse, Timothy J, David L. Morris, Kisand, K, Arden, Nigel K, Jonsson, Gudbjorn F., Arden Nigel K., Vyse, TJ, Gudbjorn F. Jonsson, Styrkarsdottir, U., Dennison, Elaine M., Doherty Sally A., Deborah J Hart, Sally A. Doherty, Valdes, Ana M., Muir, Kenneth R., Michael Doherty, Irina Kerna, Doherty, SA, Cyrus Cooper, Deborah J. Hart, Nigel K. Arden, Dennison, Elaine M, Spector, T.D., Jonsdottir, I., Jonsdottir, Ingileif, Kerna, Irina, Wheeler Margaret, Styrkarsdottir, Unnur, Kalle Kisand, Maciewicz, R.A., Tim D. Spector, Mangino, Massimo, Jonsdottir, I, Ingvarsson, Thorvaldur, Jonsson, GF, Weiya Zhang, Morris, David L.; id_orcid, Jonsson Gudbjorn F., Valdes, Ana M, Muir, Kenneth, Doherty, M, Hart, Deborah J., Ingileif Jonsdottir, Jonsdottir Ingileif, Zhang, W., Metrustry, S., Rose A. Maciewicz, Doherty, Sally A, Kisand, Kalle, Cooper, Cyrus, Nigel K Arden, Valdes, AM, Tamm, A., Stefansson, K., Maciewicz, Rose A., Maciewicz, Rose A, Massimo Mangino, Styrkarsdottir, U, Kenneth R. Muir, Dennison, EM, Spector, TD, Kenneth R Muir, Jonsson, G.F.   +151 more
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Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

The development of a quality of life instrument for osteoarthritis [PDF]

, 2007
Osteoarthritis (OA) is a common condition and a leading cause of pain and disability. The aim of this thesis was to explore issues associated with living with OA, develop an OA specific quality of life instrument and explore the physical and psychosocial
Keenan, Anne-Maree
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