Results 61 to 70 of about 462,319 (292)

Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Arthritis Research & Therapy, 2021
Background Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored
Jeong-In Yang, Jang-Soo Chun
doaj   +1 more source

Assessing knee OA severity with CNN attention-based end-to-end architectures [PDF]

, 2019
This work proposes a novel end-to-end convolutional neural network (CNN) architecture to automatically quantify the severity of knee osteoarthritis (OA) using X-Ray images, which incorporates trainable attention modules acting as unsupervised fine ...
Antony, Joseph, Giró Nieto, Xavier, Górriz, Marc, McGuinness, Kevin, O'Connor, Noel   +4 more
core  

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice [PDF]

, 2018
Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors.
A.A. Pitsillides, Altman, Arden, B. Javaheri, Bailey, Baliunas, Burger, Callewaert, Chambers, Chambers, Comhaire, Cooper, Das-Gupta, De Souza, Doube, Felson, Felson, Glasson, Goldring, Gregson, Guettler, H. Razi, Hardcastle, Hardcastle, Hardcastle, I. Maric-Mur, Javaheri, Javaheri, Javaheri, Kilkenny, Kyostio-Moore, Lajeunesse, Longo, M. Hopkinson, M. Piles, Mason, Naruse, Nevitt, P.D. Lee, Pasold, Poulet, Poulet, R. de Souza, Razi, Schneider, Sharma, Silverstein, Sowers, Spector, Stok, Strong, Tetsworth, Uchida, Vincelette, Walton, Walton, Y.-M. Chang, Zhang   +57 more
core   +4 more sources

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]

, 2009
Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core  

Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review. [PDF]

, 2018
Background:Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear.
Cole, Brian J, Cotter, Eric, Davey, Annabelle, Lansdown, Drew A, Wang, Kevin   +4 more
core   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Association of presurgical circulating MicroRNAs with 1-year postsurgical pain reduction in spine facet osteoarthritis patients with lumbar spinal stenosis

Osteoarthritis and Cartilage Open, 2022
Purpose: Up to 30% of spine facet osteoarthritis patients with lumbar spinal stenosis (SF-OA ​+ ​LSS) have little to no improvement in their pain after surgery.
Starlee Lively, Marie Milliot, Pratibha Potla, Osvaldo Espin-Garcia, Mehdi Layeghifard, Kala Sundararajan, Helal Endisha, Akihiro Nakamura, Anthony V. Perruccio, Christian Veillette, Mohit Kapoor, Y. Raja Rampersaud   +11 more
doaj   +1 more source

Difference between right and left side in total knee and unicondylar knee replacement: An interesting observation [PDF]

, 2005
We report an observation made about the differences between right and left side in case of total knee and unicondylar knee replacement. It was found that unicondylar knee replacement was performed more commonly on the left side (66%), as compared to only
Ghani, Dr. Abdul, Kypa, Dr. Padmaja, Thirumal Selvan, Dr. Vasudevan   +2 more
core   +1 more source

Acupuncture randomized trials (ART) in patients with chronic low back pain and osteoarthritis of the knee - Design and protocols [PDF]

, 2003
Background: We report on the study design and protocols of two randomized controlled trials (Acupuncture Randomized Trials = ART) that investigate the efficacy of acupuncture in the treatment of chronic low back pain and osteoarthritis of the knee ...
Becker-Witt, C., Brinkhaus, Benno, Hummelsberger, J., Irnich, D., Jena, S., Linde, K., Melchart, Dieter, Streng, A., Wagenpfeil, S., Willich, S. N.   +9 more
core   +1 more source