Results 161 to 170 of about 212,125 (236)

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Ultrasonographic Evidence of Synovitis Correlates with Synovial Citrate and TBARS in Equine Osteoarthritis. [PDF]

Vet Sci
Barreira AP, Moreira T, Silva R, Nunes L, Lioi A, Kraus E, Altheman V, Ribeiro M, Leite C, Silva A, Almeida F, Santos Junior G, Lessa D, Alves AL.   +13 more
europepmc   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Radiologic and Clinical Predictors of Reoperation Following Unilateral Biportal Endoscopic Spine Surgery: A Retrospective Cohort Study. [PDF]

Yonsei Med J
Shin JJ, Kim K, Park SJ, Jeong WJ, Yoo SJ, Shin DA, Shin J, Jang HJ, Chin DK.   +8 more
europepmc   +1 more source

Changing Habits With the Happy Hands App: Qualitative Focus Group Study of a Hand Osteoarthritis Self-Management Intervention.

J Med Internet Res
Fjeldstad KA, Tveter AT, Rasmussen E, Olden L, Nyheim S, Blanck T, Killingmo RM, Kjeken I.   +7 more
europepmc   +1 more source

Applications and Challenges of Digital Health in Rheumatology

iNew Medicine, EarlyView.
Xiao‐Xiao Li, Xue‐Er Cheng, Ming‐Ming Zhang, Peng Wang, Hai‐Feng Pan   +4 more
wiley   +1 more source

Posterior tibial slope increases over time in patients undergoing revision ACL reconstruction: A long‐term radiographic follow‐up study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Increased medial posterior tibial slope (PTS) is recognized as a significant risk factor for anterior cruciate ligament reconstruction (ACL‐R) failure. This study investigated radiographic changes in medial PTS over time among skeletally mature individuals undergoing revision ACL‐R and identified associated factors contributing to PTS ...
Mahmut Enes Kayaalp, Jumpei Inoue, Koji Nukuto, Joseph D Giusto, Gillian Ahrendt, Jonathan D. Hughes, James J. Irrgang, Thorkell Snæbjörnsson, Jon Karlsson, Volker Musahl   +9 more
wiley   +1 more source