Results 1 to 10 of about 69,265 (119)

Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2

eLife, 2022
Background: Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct osteoarthritis phenotype defined by the coexistence of MetS or its individual components. Despite the high prevalence of MetS-OA, its pathogenic mechanisms are unclear.
Weiping Su, Guanqiao Liu, Bahram Mohajer, Jiekang Wang, Alena Shen, Weixin Zhang, Bin Liu, Ali Guermazi, Peisong Gao, Xu Cao, Shadpour Demehri, Mei Wan   +11 more
doaj   +1 more source

β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN

Experimental Gerontology, 2023
Senescence chondrocytes play an important role in Osteoarthritis (OA) progression. However, alleviating OA progression through senescent chondrocyte intervention still faces great challenges.
Guang Xia, Zi Wen, Lina Zhang, Junjie Huang, Xinxing Wang, Chi Liang, Xiaoyu Cui, Xu Cao, Song Wu   +8 more
doaj   +1 more source

Increasing the capacity of health cadres to prevent and self-management of Osteoarthritis

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang, 2023
Osteoarthritis (OA) is a clinical syndrome characterized by joint pain with varying degrees of functional limitations that impact quality of life. Data in Indonesia shows that the national prevalence of osteoarthritis is 7.3%. Several factors in the high
Arifin Triyanto, Heny Suseani Pangastuti, Diana Nurlita, Anisah Umami   +3 more
doaj   +1 more source

Profile of Patients’ Osteoarthritis at Tertiary and Teaching in Aceh, Indonesia

Surabaya Physical Medicine and Rehabilitation Journal, 2023
Background: Osteoarthritis is a degenerative joint disease characterized by damage of cartilage in the joints and subchondral bones that cause pain in a joint.
Alex Kurniawan Gan, Safrizal Rahman, Armia Indra Nur Alam, Bellinda Paterasari   +3 more
doaj   +1 more source

Epigenetic Regulation in Knee Osteoarthritis

Frontiers in Genetics, 2022
Osteoarthritis (OA) is a complicated disease with both hereditary and environmental causes. Despite an increase in reports of possible OA risk loci, it has become clear that genetics is not the sole cause of osteoarthritis.
Zhengyu Cai, Teng Long, Yaochao Zhao, Ruixin Lin, You Wang   +4 more
doaj   +1 more source

Correlation between Serum Leptin with Severity of Knee Osteoarthritis [PDF]

Al-Azhar International Medical Journal, 2023
Background: Knee osteoarthritis (OA), is a joint degeneration in the knee. due to progressive articular cartilage loss. Knee OA patients’ quality of life may be impacted by pain, physical restrictions, subpar treatment results, and more medication ...
Ahmad Shaalan, ahmed saad, ahmed ezz, Khaled Amer   +3 more
doaj   +1 more source

Depression development in patients with OA, and its impact on treatment outcome - a literature review

Journal of Education, Health and Sport, 2023
Introduction and aim of the study: Osteoarthritis (OA) and depression are leading causes of disease burden worldwide and important public health problems.
Ignacy Tołwiński, Klaudia Dadas, Aleksandra Świercz, Urszula Żurek, Zofia Kędzierska, Dominika Małachowska, Hubert Ciecierski-Koźlarek, Klaudia Antkowiak, Justyna Popczyńska, Kinga Woźniak, Patryk Hedesz, Andrzej Taras, Kateryna Shved   +12 more
doaj   +1 more source

Pros and cons of mouse models for studying osteoarthritis

Clinical and Translational Medicine, 2018
Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability.
Santul Bapat, Daniel Hubbard, Akul Munjal, Monte Hunter, Sadanand Fulzele   +4 more
doaj   +1 more source

Physical Activity for Osteoarthritis: A Cross-Sectional Study

Physical Education Theory and Methodology, 2023
Background. Physical activity is a fundamental and proactive form of conservative treatment for persons with knee osteoarthritis. Study purpose. This study aims to investigate risk variables for individuals in Indonesia who had knee osteoarthritis (OA).
Nur Azis Rohmansyah, Sumarjo, Ashira Hiruntrakul   +2 more
doaj   +1 more source

Relationship between the stage of osteoarthritis before and six months after tibial tuberosity advancement procedure in dogs.

PLoS ONE, 2019
The present retrospective study evaluated the progression of osteoarthritis in stifle joints based on the radiographic grade of osteoarthritis (OA) scored in dogs with cranial cruciate ligament rupture.
Stefania Pinna, Francesco Lanzi, Alessia Cordella, Alessia Diana   +3 more
doaj   +1 more source