Results 31 to 40 of about 497,266 (304)

Future directions for the management of pain in osteoarthritis. [PDF]

, 2014
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA
Kuttapitiya, A, Sofat, N
core   +1 more source

MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study

The Scientific World Journal, 2012
Background. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case ...
Jiaao Gu, Jiesheng Rong, Fulin Guan, Liying Jiang, Shuqing Tao, Guofa Guan, Tianzun Tao   +6 more
doaj   +1 more source

Causal association of genetically determined plasma metabolites with osteoarthritis: a two-sample Mendelian randomization study

Frontiers in Medicine
BackgroundWe aimed to elucidate the causal relationship between plasma metabolites and the vulnerability to Osteoarthritis (OA), encompassing both hip OA and knee OA.MethodsWe conducted a two-way two-sample Mendelian randomization (MR) analysis to ...
Qingsong Fu, Xinhua Yuan, Weibin Wang, Xinyou Han, Jiakai Zhang, Junlong Wu, Yao Wang   +6 more
doaj   +1 more source

"Let's talk about OA pain": a qualitative analysis of the perceptions of people suffering from OA. Towards the development of a specific pain OA-Related questionnaire, the Osteoarthritis Symptom Inventory Scale (OASIS). [PDF]

PLoS ONE, 2013
INTRODUCTION:Pain is the primary outcome measurement in osteoarthritis, and its assessment is mostly based on its intensity. The management of this difficult chronic condition could be improved by using pain descriptors to improve analyses of painful ...
Christine Cedraschi, Sylvie Delézay, Marc Marty, Francis Berenbaum, Didier Bouhassira, Yves Henrotin, Françoise Laroche, Serge Perrot   +7 more
doaj   +1 more source

TSG-6 – a double-edged sword for osteoarthritis (OA) [PDF]

Osteoarthritis and Cartilage, 2018
To explore mechanisms underlying the association of TSG-6 with osteoarthritis (OA) progression.TSG-6-mediated heavy chain (HC) transfer (TSG-6 activity) and its association with inflammatory mediators were quantified in knee OA (n=25) synovial fluids (SFs).
C.-H. Chou, D.E. Attarian, H.-G. Wisniewski, P.A. Band, V.B. Kraus   +4 more
openaire   +2 more sources

Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis. [PDF]

, 2014
Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can
Wahida Rahman, Anthony H Dickenson, Rahman, W, Dickenson, AH   +3 more
core   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients

Osteoarthritis and Cartilage Open
Objective: To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoarthritis, and advanced hip ...
Ronan J. Anderson, Brent A. Lanting, C. Thomas Appleton, Ryan M. Degen   +3 more
doaj   +1 more source

Cross-sectional study on the relationship between Body Mass Index and severity of knee osteoarthritis [PDF]

Romanian Journal of Rheumatology
Background. Musculoskeletal diseases like osteoarthritis (OA) are widespread. OA affects the knees, makes the joints wear out and hurt, and makes it hard to move around.
Mohd. Shifa Hasan, Aditya Kumar Mishra, Mohd. Bilal Kaleem, Vikash Thaledi   +3 more
doaj   +1 more source

Large scale replication study of the association between HLA II/BTNL2 variants and osteoarthritis of the knee in European-descent populations [PDF]

, 2011
Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and ...
Spector Tim D., Rose A Maciewicz, Maciewicz Rose A., Doherty Michael, Ana M. Valdes, Jonsson, Helgi, Morris, David L., Zhang Weiya, Tamm Agu, Jonsson, Gudbjorn F, Ingvarsson Thorvaldur, Unnur Styrkarsdottir, Doherty, Sally A., David L Morris, Stefansson Kari, Zhang, Weiya, Hart Deborah J., Ana M Valdes, Thorvaldur Ingvarsson, Mangino, M., Tamm Ann, Arden, N., Agu Tamm, Cooper Cyrus, Tim D Spector, Muir Kenneth R., Wheeler, M., Vyse, T.J., Stefansson, Kari, Gudbjorn F Jonsson, Sarah Metrustry, Margaret Wheeler, Arden, N.K., Helgi Jonsson, Valdes, A.M., Vyse Timothy J., Sally A Doherty, Mangino Massimo, Kerna Irina, Spector, T. D., Hart, Deborah J, Arden, Nigel K., Tamm, Ann, Timothy J. Vyse, Morris, David L, Kisand Kalle, Ann Tamm, Vyse, Timothy J., Dennison Elaine M., Metrustry, Sarah, Jonsson Helgi, Tamm, Agu, Morris, D.L., Cooper, C., Spector, Tim D., Wheeler, Margaret, Kari Stefansson, Ingvarsson, T., Valdes Ana M., Timothy J Vyse, Muir, Kenneth R, Dennison, E.M., Elaine M Dennison, Doherty, M., Spector, Tim D, Morris David L., Elaine M. Dennison, Hart, D.J., Hart, Deborah J.; id_orcid, Doherty, Michael, Muir, K.R., Metrustry Sarah, Styrkarsdottir Unnur, Vyse, Timothy J, David L. Morris, Arden, Nigel K, Jonsson, Gudbjorn F., Arden Nigel K., Gudbjorn F. Jonsson, Styrkarsdottir, U., Dennison, Elaine M., Doherty Sally A., Deborah J Hart, Sally A. Doherty, Valdes, Ana M., Muir, Kenneth R., Michael Doherty, Irina Kerna, Cyrus Cooper, Deborah J. Hart, Nigel K. Arden, Dennison, Elaine M, Spector, T.D., Jonsdottir, I., Jonsdottir, Ingileif, Kerna, Irina, Wheeler Margaret, Styrkarsdottir, Unnur, Kalle Kisand, Maciewicz, R.A., Tim D. Spector, Mangino, Massimo, Ingvarsson, Thorvaldur, Weiya Zhang, Morris, David L.; id_orcid, Jonsson Gudbjorn F., Valdes, Ana M, Muir, Kenneth, Hart, Deborah J., Ingileif Jonsdottir, Jonsdottir Ingileif, Zhang, W., Metrustry, S., Rose A. Maciewicz, Doherty, Sally A, Kisand, Kalle, Cooper, Cyrus, Nigel K Arden, Tamm, A., Stefansson, K., Maciewicz, Rose A., Maciewicz, Rose A, Massimo Mangino, Kenneth R. Muir, Kenneth R Muir, Jonsson, G.F., Vyse, Timothy J.; id_orcid   +126 more
core   +1 more source