Results 51 to 60 of about 497,266 (304)

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

, 2008
Osteoarthritis (OA) is generally a disease of the elderly population, but can occur in young patients in exceptional cases. This study compares the cellular and epigenetic features of primary old-age OA with those of secondary OA in a 23-year old patient
da Silva, M.A., Roach, H.I., Yamada, N., Clarke, N.M.   +3 more
core   +1 more source

Estimating the Prevalence and Incidence of Symptomatic Hand Osteoarthritis in the Netherlands Using Primary Care Electronic Health Records

Arthritis Care &Research, EarlyView.
Objective Estimating the incidence and prevalence of symptomatic hand osteoarthritis (OA) in the Dutch population using a validated algorithm that integrates free‐text data from primary care electronic health records (EHRs). Methods This retrospective cohort study used the Integrated Primary Care Information database, including EHRs from approximately ...
Onur Kaya, Jacoline van den Driest, Laura Struik, Margreet Kloppenburg, Ruud Selles, Daniel Prieto Alhambra, Sita Bierma‐Zeinstra, Dieuwke Schiphof   +7 more
wiley   +1 more source

Senescence in osteoarthritis: from mechanism to potential treatment

Arthritis Research & Therapy, 2022
Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte senescence has been extensively studied in recent years. Increased numbers of senescent chondrocytes are found in OA cartilage.
Yikai Liu, Zian Zhang, Tao Li, Hao Xu, Haining Zhang   +4 more
doaj   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High Body Mass Index

Arthritis Care &Research, EarlyView.
Objective High body mass index (BMI ≥ 27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

The Methylation Pattern for Knee and Hip Osteoarthritis

Frontiers in Cell and Developmental Biology, 2020
Osteoarthritis is one of the most prevalent chronic joint diseases for middle-aged and elderly people. But in recent years, the number of young people suffering from the disease increases quickly.
Zhen Wu, Lu Shou, Jian Wang, Tao Huang, Xinwei Xu   +4 more
doaj   +1 more source

Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis

Human Genomics, 2021
Objective The occurrence of osteoarthritis is related to genetic and environmental factors. Among them, the change of chondrocyte gene expression pattern regulated by epigenetic modification is an important participant.
Guoliang Wang, Yanlin Li, Guang Yang, Tengyun Yang, Lu He, Yang Wang   +5 more
doaj   +1 more source

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis [PDF]

, 2013
Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA).
Muthuri, Stella G., Sally Doherty, Weiya Zhang, Zhang, W, Rose A Maciewicz, Maciewicz, Rose A., Muir, Kenneth, Doherty, M, Doherty, S, Muir, K; id_orcid, Stella G Muthuri, Muir, Kenneth R., Doherty, Sally A., Muthuri, S G, Doherty, Sally, Maciewicz, R A, Kenneth R Muir, Michael Doherty, Zhang, Weiya, Doherty, Michael   +19 more
core   +1 more source

The Content and Reporting Completeness of Physical Therapist–Led Interventions for Glenohumeral Osteoarthritis: A Systematic Review

Arthritis Care &Research, EarlyView.
Objective This study synthesized the content and reporting completeness of published physical therapist–led interventions for glenohumeral osteoarthritis (GHOA). Methods This systematic review undertook electronic database searches in PubMed, EMBASE, Cochrane, CINAHL, and PEDro (until June 2025) for any peer‐reviewed articles or studies describing ...
Daha G. Muhammad, Nadine E. Foster, Mickylle Pelaez, Karina O'Leary, Ilana N. Ackerman, Jonathan G. Quicke   +5 more
wiley   +1 more source

Artificial Intelligence‐Driven Extraction of Patient‐Reported Pain Outcomes in Osteoarthritis Using Large Language Models

Arthritis Care &Research, Accepted Article.
Objective Patient‐reported outcome measures (PROMs) are central to assessing symptom burden and treatment response in Osteoarthritis (OA) but are often embedded in unstructured clinical notes. We evaluated whether prompt‐engineered large language models (LLMs) could accurately extract or infer pain scores on a 0‐10 scale from routine OA clinical ...
Jainesh Doshi, Stephen Batter, Yiyuan Wu, William Salerno, Alice Santilli, Sandhya Kannayiram, Susan Goodman, Bella Mehta   +7 more
wiley   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source