Results 61 to 70 of about 497,266 (304)

Reliability of radiographic knee and hip osteoarthritis classification between radiologists and orthopaedic surgeons

Journal of Orthopaedic Surgery and Research
Introduction Osteoarthritis (OA) is a common and disabling joint condition that requires accurate assessment for effective management. Variability in radiographic classification of OA severity can impact diagnostic accuracy and treatment decisions.
Henriette M. Eijking, Robin Voskuilen, Pieter Tilman, Martijn G. M. Schotanus, Bob Jong, Bert Boonen, Jasper Most   +6 more
doaj   +1 more source

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis [PDF]

, 2011
Objective To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 ( TRPV1 ) is associated with genetic risk of painful knee osteoarthritis (OA). Methods The Ile585Val TRPV1 variant encoded
K. R. Muir, Lories, RJ, C. Cooper, Hart, DJ, D. J. Hart, W. Zhang, Dennison, Elaine M., Arden, Nigel, S. A. Doherty, Chapman, Victoria, Cicuttini, FM, Valdes, Ana M., Doherty, Sally A., Muir, Kenneth R., Vaughn, Frances L., T. D. Spector, Zhang, Weiya, Laslett, LL, Doherty, SA, Arden, N., Lories, Rik J., Chapman, V, Jones, Graeme, A. Soni, Muir, KR, P. Leaverton, V. Chapman, Leaverton, Paul, Spector, T. D., Arden, Nigel K., Jones, G, Cicuttini, Flavia M., Wilde, Gert De, Muir, Kenneth, Doherty, M, G. Jones, Hart, Deborah J., Wheeler, M, R. A. Maciewicz, Leaverton, P, Cooper, Cyrus, N. K. Arden, Valdes, AM, G. De Wilde, Laslett, Laura L., Vaughn, FL, F. L. Vaughn, De Wilde, G, Zhang, W, A. M. Valdes, Maciewicz, Rose A., Maciewicz, RA, Spector, Tim D., Wheeler, Margaret, Dennison, EM, Spector, TD, M. Doherty, Cooper, C, R. J. Lories, M. Wheeler, Soni, Anushka, E. M. Dennison, F. M. Cicuttini, L. L. Laslett, De Wilde, Gert, Hart, Deborah J.; id_orcid, Doherty, Michael   +66 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Association of Knee Osteoarthritis with Difficulty During Activities of Daily Life in Elderly Females: A Cross Sectional Study

Journal Riphah College of Rehabilitation Sciences, 2020
Objectives: This study aims to determine association between knee osteoarthritis (OA) and difficulty during activities of daily living in elderly female patients.
Sidra Firdous Iqbal, Arzoo Nawaz, Arooj Fatima   +2 more
doaj  

Numerical analysis of cartilage surfaces for osteoarthritis diagnosis using field and feature parameters [PDF]

, 2011
Osteoarthritis (OA) is one of the most common degenerative wear diseases of knee joints worldwide. Within knee joint articular cartilage (AC), collagen structure losing integrity is a major symptom of OA.
Jiang, X., Wang, Jian, Tian, Y., Z. Peng, X. Jiang, J. Wang, Jiang, Xiang, Y. Tian, Wang, J., Peng, Z.   +9 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP–RIPK1–NF-κB axis and influencing autophagy

Journal of Translational Medicine
Background Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability.
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu   +10 more
doaj   +1 more source

Differences in articular hip cartilage gene expression between femoroacetabular impingement (FAI) and end-stage hip osteoarthritis

Orthopaedic Journal of Sports Medicine, 2020
Objectives: The morphological deformities in Femoroacetabular Impingement (FAI) have been associated with hip osteoarthritis (OA), however the molecular mechanisms for OA initiation and progression are poorly understood.
John Reuter, Gillian Soles, Cheryl Ackert-Bicknell PhD, Brian Giordano, Benjamin Kuhns   +4 more
doaj   +1 more source

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source