Results 81 to 90 of about 126,184 (308)

ULTRASOUND, TENS DAN KINESIOTAPING MENINGKATKAN AKTIFITAS FUNGSIONAL PADA OSTEOARTHRITIS LUTUT

Jurnal Fisioterapi dan Rehabilitasi, 2020
Osteoarthritis (OA) Lutut adalah gangguan degeneratif pada sendi lutut yang megakibatkan nyeri dan gangguan gerak. Timbulnya nyeri tersebut mengakibatkan penurunan aktifitas fungsional pada pasien OA lutut.
Indah Pramita
doaj   +1 more source

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]

, 2010
Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P., Clark, Ian M., Davidson, Rose K., Gabrielides, Christos, Kirkwood, Tom B. L., Scott, Jenny L., Swingler, Tracey E., Talyor, Robert W., Wallis, Gillian A., Young, David A.   +9 more
core   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases

Angewandte Chemie, EarlyView.
A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy, Ugo Pasco, Mylene Sejalon‐Cipolla, Pierrick Bruyat, Monika Kaminska, Carole Malgorn, Fabrice Beau, Manca Osolin, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia, Emeline Groult, Olivier Lequin, Sarah Bregant, Yves‐Marie Pers, Daniele Noel, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel   +20 more
wiley   +2 more sources

Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in osteoarthritis by integrating bioinformatics and machine learning

Frontiers in Immunology
ObjectiveExosomes as important carriers of intercellular communication have frequently appeared in recent studies related to osteoarthritis (OA), while the specific mechanism of exosome action in osteoarthritis remains unclear.
Tianyang Li, Jinpeng Wei, Hua Wu, Chen Chen   +3 more
doaj   +1 more source

Reactivation of NR4A1 Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in Rats

Frontiers in Cell and Developmental Biology, 2020
Osteoarthritis (OA) is the most prevalent joint disease and uncontrolled inflammation is now recognized to play vital roles in OA development. Targeting the endogenous counterpart of inflammation may develop new therapeutic approaches in resolving ...
Yan Xiong, Jisheng Ran, Langhai Xu, Zhou Tong, Moqbel Safwat Adel Abdo, Chiyuan Ma, Kai Xu, Yuzhe He, Zhipeng Wu, Zhonggai Chen, Pengfei Hu, Lifeng Jiang, Jiapeng Bao, Weiping Chen, Lidong Wu   +14 more
doaj   +1 more source

Screening for hand osteoarthritis (OA) using a postal survey

Osteoarthritis and Cartilage, 1999
The aim of this study was to determine the feasibility of screening for hand osteoarthritis (OA) using a postal survey.Men and women aged 40-79, selected at random from a general practice in Nottingham, were sent a postal survey concerning arm pain. Subjects were asked to identify presence of any nodes, based on a diagrammatic example, and to document ...
O'Reilly, S, Johnson, S, Doherty, S, Muir, K, Doherty, M   +4 more
openaire   +2 more sources

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Bio‐Propelled Stomatocyte Nanomotors with Glutathione‐Responsiveness for Osteoarthritis Treatment

Angewandte Chemie, EarlyView.
Glutathione (GSH)‐responsive stomatocyte nanomotors with encapsulated MTX utilize oxygen to achieve autonomous motion and undergo GSH‐induced dissociation, enhancing cellular uptake, tissue penetration, and MTX release within the osteoarthritis (OA) region, thereby improving therapeutic efficacy.
Jianhong Wang, Mengsi Zhan, Hanglong Wu, Maarten Bransen, Ioanna Balmpouzi, Xianwen Lou, Junjie Liu, Nina Wang, Zhiqiang Wang, Heiner Friedrich, Jingxin Shao, Jan C. M. van Hest, Xiangyang Shi   +12 more
wiley   +2 more sources

Acute Effects of Walking on The Deformation of Femoral Articular Cartilage

, 2017
Background and Purpose: Knee osteoarthritis (OA) is characterized by a progressive loss of the articular cartilage, increasing the amount of friction in the joint, resulting in pain and decreases in mobility and function.
McClaren, Jayson, Sudweeks, Skyler
core   +1 more source