Results 81 to 90 of about 497,266 (304)

The Impact of Body Mass Index on Osteoarthritis Severity Levels

Media Keperawatan Indonesia
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage damage, with pain being one of the most frequent complaints among patients.
Siti Juhro, Much Nurkharistna Al Jihad, Machmudah Machmudah, Dera Alfiyanti   +3 more
doaj   +1 more source

Reactivation of NR4A1 Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in Rats

Frontiers in Cell and Developmental Biology, 2020
Osteoarthritis (OA) is the most prevalent joint disease and uncontrolled inflammation is now recognized to play vital roles in OA development. Targeting the endogenous counterpart of inflammation may develop new therapeutic approaches in resolving ...
Yan Xiong, Jisheng Ran, Langhai Xu, Zhou Tong, Moqbel Safwat Adel Abdo, Chiyuan Ma, Kai Xu, Yuzhe He, Zhipeng Wu, Zhonggai Chen, Pengfei Hu, Lifeng Jiang, Jiapeng Bao, Weiping Chen, Lidong Wu   +14 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Association between serum high-sensitivity C-reactive protein levels and osteoarthritis in adults from NHANES 2015 to 2018

Scientific Reports
To explore the association between serum high-sensitivity C-reactive protein (HSCRP) levels and osteoarthritis (OA) in adults, providing new evidence for the diagnosis of adult OA.
Tao Gao, Zhi-Yu Chen, Tao Li, Xu Lin, Hai-Gang Hu, Fan Wu, Chao Wu   +6 more
doaj   +1 more source

Antihypertensive drug-associated adverse events in osteoarthritis: a study of a large real-world sample based on the FAERS database

Frontiers in Pharmacology
BackgroundHypertension is a common complication in patients with osteoarthritis (OA). There is increasing interest in the relationship between hypertension and OA.
Zijian Guo, Jingkai Di, Zhibo Zhang, Shuai Chen, Xingjia Mao, Zehua Wang, Zehui Yan, Xiaoke Li, Zui Tian, Changjiang Mu, Changxin Xiang, Chuan Xiang   +11 more
doaj   +1 more source

Osteoarthritis Bone Marrow Lesions. [PDF]

, 2023
Assessment and treatment of Bone Marrow Lesions (BMLs) could ultimately make step changes to the lives of people with osteoarthritis (OA). We here review the imaging and pathological characteristics of OA-BMLs, their differential diagnosis and ...
Walsh, David A
core  

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression

, 2016
To determine prevalence, incidence and progression of radiographic knee osteoarthritis (OA) in a cohort of subjects with previous ...
Lohmander, Stefan,, Paradowski, Przemysław T,, Englund, Martin,, Lund University.   +3 more
core   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

A naturally aging knee, or development of early knee osteoarthritis?

, 2018
Aim: To study the development of early knee osteoarthritis (OA) in subjects with and without risk factors for knee OA. Methods: We studied 340 subjects from the Osteoarthritis Initiative (OAI), aged 45–55 years (51% women), free of radiographic knee OA ...
Magnusson, K., Kumm, J., Englund, M., Turkiewicz, A., Kumm, J.,, Englund, M.,, Turkiewicz, A.,, Lund University., Magnusson, K.,   +8 more
core   +1 more source