Results 91 to 100 of about 126,184 (308)

The genetic contribution to severe post-traumatic osteoarthritis [PDF]

, 2013
Objective: to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.
Ana M Valdes, Anderson, arcOGEN Consortium and arcOGEN Collaborators, Brown, Castaño-Betancourt, Day-Williams, Dieppe, Doherty, Englund, Evangelou, Herrero-Beaumont, Kenneth R Muir, Lopez, Margaret Wheeler, Michael Doherty, Muthuri, Rose A Maciewicz, Sally A Doherty, Sward, Valdes, Valdes, Weiya Zhang   +21 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Impact of Body Mass Index on Osteoarthritis Severity Levels

Media Keperawatan Indonesia
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage damage, with pain being one of the most frequent complaints among patients.
Siti Juhro, Much Nurkharistna Al Jihad, Machmudah Machmudah, Dera Alfiyanti   +3 more
doaj   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Automatic Grading of Individual Knee Osteoarthritis Features in Plain Radiographs Using Deep Convolutional Neural Networks

Diagnostics, 2020
Knee osteoarthritis (OA) is the most common musculoskeletal disease in the world. In primary healthcare, knee OA is diagnosed using clinical examination and radiographic assessment.
Aleksei Tiulpin, Simo Saarakkala
doaj   +1 more source

Arthroscopic washout of the knee: a procedure in decline. [PDF]

, 2014
BACKGROUND: Osteoarthritis (OA) of the knee is a chronic, progressive condition which often requires surgical intervention. The evidence for the benefits of arthroscopic debridement or washout for knee OA is weak and arthroscopy is currently only ...
American Academy of Orthopaedic Surgeons, Andersson-Molina, Arthritis Care, Bernard, Burr, Cameron-Donaldson, Caroline Hing, Cicuttini, Clements, Cooper, Dhawan, Felson, Grenier, Hospital Episode Statistics: Health and Social Care Information Centre, Jason Bernard, Lane, Laupattarakasem, Loeser, Losina, National Institute for Health and Care Excellence, National Institute for Health and Clinical Excellence, Oliver Boughton, Rosenthal, Sihvonen, Sowers, Spector, Srikanth, Stefan Lazic, Zhang   +28 more
core   +1 more source

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Association between serum high-sensitivity C-reactive protein levels and osteoarthritis in adults from NHANES 2015 to 2018

Scientific Reports
To explore the association between serum high-sensitivity C-reactive protein (HSCRP) levels and osteoarthritis (OA) in adults, providing new evidence for the diagnosis of adult OA.
Tao Gao, Zhi-Yu Chen, Tao Li, Xu Lin, Hai-Gang Hu, Fan Wu, Chao Wu   +6 more
doaj   +1 more source

Antihypertensive drug-associated adverse events in osteoarthritis: a study of a large real-world sample based on the FAERS database

Frontiers in Pharmacology
BackgroundHypertension is a common complication in patients with osteoarthritis (OA). There is increasing interest in the relationship between hypertension and OA.
Zijian Guo, Jingkai Di, Zhibo Zhang, Shuai Chen, Xingjia Mao, Zehua Wang, Zehui Yan, Xiaoke Li, Zui Tian, Changjiang Mu, Changxin Xiang, Chuan Xiang   +11 more
doaj   +1 more source

Chaos Analysis of Knee Osteoarthritis (OA) Patients' Gait

Rigakuryoho Kagaku, 2007
3次元動作解析装置を用いて変形性膝関節症患者と健常者の歩行中の関節角度計測を行い，3歩行周期の膝関節角度データをカオス解析した。カオス性を表す指標となるリアプノフ指数を用いて両者を比較すると，膝OA群は健常高齢群に比して有意に低い値を示した（健常群：1.90±0.59，膝OA群：1.61±0.40 ...
Osamu AOKI, Shinji KAGAWA, Shozo KAWAMURA, Souitiro HIRATA   +3 more
openaire   +2 more sources