Results 91 to 100 of about 497,266 (304)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Strategies for managing osteoarthritis [PDF]

, 2011
Although there are recommendations for the management of osteoarthritis (OA), little is known about how people with OA actually manage this chronic ...
Norman Tiong Meng Ng, Heesch, Kristiann C., Kristiann C. Heesch, Ng, Norman, Ng, Norman T., Brown, Wendy J., Heesch, Kristiann, Wendy J. Brown   +7 more
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries [PDF]

, 2008
Background: Diclofenac is a commonly used non-steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries.
Banning, M
core   +1 more source

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source

The two-year incidence of hip osteoarthritis after arthroscopic hip surgery for femoroacetabular impingement syndrome

BMC Musculoskeletal Disorders, 2019
Background One of the reported goals of hip preservation surgery is to prevent or delay the onset of osteoarthritis. This includes arthroscopic surgery to manage Femoroacetabular Impingement (FAI) Syndrome.
Daniel I. Rhon, Tina A. Greenlee, Charles Dennis Sissel, Michael P. Reiman   +3 more
doaj   +1 more source

Osteoarthritis (OA) [PDF]

, 2019
Osteoarthritis (OA) is the primary cause of chronic pain, affecting approximately 27 million people in the United States. OA is a disease in the synovial joint. In humans, the knee is the largest synovial joint.
Steele, Erin
core  

Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. [Elektronisk resurs]

, 2014
To estimate the current and future (to year 2032) impact of osteoarthritis (OA) health care ...
Lohmander, Stefan,, Turkiewicz, Aleksandra,, Petersson, Ingemar,, Björk, Jonas,, Hawker, G, Dahlberg, Leif,, Englund, Martin,, Lund University.   +7 more
core   +1 more source

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study [PDF]

, 2013
ObjectiveVariation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA).
Pannoutsopoulou, K., Wheeler, M., Jones, G., Spector, T.D., Laslett, L.L., Cicuttini, F.M., Cooper, C., Metrustry, S., Zhang, W., Doherty, S., Arden, N.K., Doherty, M., Valdes, A.M., Zeggini, E., Maciewicz, R.A., Hart, D.J., Muir, K.R., Arden, Nigel K, HASH(0x55a67fff9a48), Cicuttini, Flavia M; id_orcid, Valdes, Ana Maria, Zeggini, Eleftheria, Valdes, Ana M., Laslett, Laura L, Doherty, Sally A., Muir, Kenneth R., Zhang, Weiya, Arden, N., Jones, Graeme, ?, ?, Hart, Deborah J; id_orcid, Spector, T. D., Hart, Deborah J, Arden, Nigel K., Cicuttini, Flavia M., Valdes, Ana M, Muir, Kenneth, Hart, Deborah J., Doherty, Sally A, Cooper, Cyrus, Laslett, Laura L., Metrustry, Sarah, Maciewicz, Rose A., Maciewicz, Rose A, Cicuttini, Flavia M, Spector, Tim D., Wheeler, Margaret, Panoutsopoulou, Kalliope, Laslett, Laura, Muir, Kenneth R, Spector, Tim D, Doherty, Michael   +51 more
core   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source