Results 101 to 110 of about 497,266 (304)

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

EPIDEMIOLOGY OF OSTEOARTHRITIS (OA) IN WOMEN

Journal of Bio Innovation
Osteoarthritis (OA) is a type of arthritis that causes joint pain and impairment of function. Although osteoarthritis has commonly been attributed to the “wear and tear” of aging, it is now understood as a complex disease involving breakdown of cartilage between bones, bone remodeling, and joint inflammation. Although it involves any joint in the body,
openaire   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis [PDF]

, 2010
Osteoarthritis (OA) is a global clinical challenge for which no effective disease modifying agents currently exist. Herein we identify protease-activated receptor-2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in OA ...
McInnes, I.B., Lockhart, J.C., Ferrell, W.R., Kelso, E.B., Plevin, R.J.   +4 more
core   +2 more sources

Favorable Functional Outcomes and Low Instability Recurrence Rates After the Latarjet Procedure in Adolescent Patients: A Systematic Review

Arthroscopy, EarlyView.
Purpose To assess clinical, functional, and radiographic outcomes as well as return‐to‐sports (RTS) rates in adolescent patients (aged 10‐19 years according to the World Health Organization) who underwent the Latarjet procedure. Methods A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta ...
Peter Rab, Igor J. Shirinskiy, Thibault Lafosse, Peter J. Millett, Doruk Akgün, Sebastian Siebenlist, Lucca Lacheta, Maximilian Hinz   +7 more
wiley   +1 more source

OA fundamentals series: Diagnosis and clinical assessment of osteoarthritis

Osteoarthritis and Cartilage
Osteoarthritis (OA), the most common form of arthritis, is a heterogenous condition with substantial variability in clinical presentation. Despite its high prevalence, OA is frequently underdiagnosed and inadequately managed. A clinician's diagnosis is an important step to facilitate access to and engagement with treatment.
Lauren K. King, Abhishek Abhishek
openaire   +2 more sources

Characteristics of patients with knee osteoarthritis (OA) surveyed in developing the Knee Osteoarthritis Fears and Beliefs Questionnaire.

, 2013
Characteristics of patients with knee osteoarthritis (OA) surveyed in developing the Knee Osteoarthritis Fears and Beliefs Questionnaire.
Isabelle Boutron (28574), Sophie Alami (275579), Philippe Ravaud (28576), Mathilde Benhamou (275578), François Rannou (77842), Gabriel Baron (23457), Serge Poiraudeau (77846), Marie Dalichampt (136441)   +7 more
core   +1 more source

Preoperative Sagittal Tibial Tubercle‐Trochlear Groove Distance Predicts Postoperative Outcome in Patients Undergoing Combined Trochleoplasty and Medial Patellofemoral Ligament Reconstruction

Arthroscopy, EarlyView.
Purpose To evaluate the association between the preoperative sagittal tibial tubercle‐trochlear groove (sTTTG) distance and postoperative patient‐reported outcomes after combined patellofemoral ligament reconstruction and deepening trochleoplasty in patients with recurrent lateral patellar instability and high‐grade trochlear dysplasia.
Sebastian Schmidt, Luis Navas, Felix Zimmermann, Abd El Nasser Oudeh, Christian Lattermann, Peter Balcarek   +5 more
wiley   +1 more source

Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging. [PDF]

Bioengineering (Basel), 2023
Vun J, Iqbal N, Jones E, Ganguly P.
europepmc   +1 more source

IntrAarticular Injections for Osteoarthritis (OA)

The Arab Journal of Interventional Radiology, 2023
Caleb Solivio, Shivraj Grewal, Ahmad Alach, Talha Shabbir, Muhammad Ghauri, Mason Eghbali, Austin Shinagawa, Alok Bhatt, Geogy Vatakencherry, Kartik Kansagra   +9 more
openaire   +1 more source