Results 111 to 120 of about 126,184 (308)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Long‐Term Outcomes Following Anatomic Double‐Bundle Versus Single‐Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Autograft: A Randomized Controlled Trial With an Average 14‐Year Follow‐Up

Arthroscopy, EarlyView.
Purpose To compare the clinical and radiographic outcomes—particularly the long‐term development of osteoarthritis—14 years after anterior cruciate ligament (ACL) reconstruction between anatomic double‐bundle (DB) and anatomic single‐bundle (SB) techniques.
Dlshad Qadir, Ninni Sernert, Lars Rostgard‐Christensen, Neel Desai, Mattias Ahldén, Jüri‐Toomas Kartus, Ioannis Karikis   +6 more
wiley   +1 more source

Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging. [PDF]

Bioengineering (Basel), 2023
Vun J, Iqbal N, Jones E, Ganguly P.
europepmc   +1 more source

Valgus malalignment and prevalence of lateral compartmental radiographic knee osteoarthritis (OA): The Wuchuan OA study

International Journal of Rheumatic Diseases, 2017
AbstractAimTo evaluate whether knee alignment explains the higher prevalence of lateral compartment tibiofemoral radiographic osteoarthritis (TFROA) among rural Chinese compared with that among Whites.MethodsThe Wuchuan OA Study is a population‐based longitudinal study of risk factors for knee OA.
Bin Wang, Qiang Liu, Barton L. Wise, Yan Ke, Dan Xing, Yuankun Xu, Yuqing Zhang, Jianhao Lin   +7 more
openaire   +4 more sources

Prevalence of Cam Femoroacetabular Lesions in Medieval (1200‐1600 CE) and Postmedieval (1600‐1850 CE) Dutch Skeletal Collections

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate medieval and postmedieval Dutch skeletal collections for signs of cam impingent. Methods The medieval collections from Alkmaar Paardenmarkt and Klaaskinderkerke and the postmedieval period from Middenbeemster were studied. Standard osteological methods for sex and age estimation were used. From digital photographs of the femora, the
Nouschka Bosch, Sarah Schrader, Daniel Cooperman, Randall T. Loder   +3 more
wiley   +1 more source

Ultrasonic reflection coefficient and surface roughness index of OA articular cartilage: relation to pathological assessment

BMC Musculoskeletal Disorders, 2012
Background Early diagnosis of Osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathological grades and quantitative ...
Niu Hai-jun, Wang Qing, Wang Yue-xiang, Li De-yu, Fan Yu-bo, Chen Wu-fan   +5 more
doaj   +1 more source

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (<i>TrkA</i>) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization. [PDF]

Int J Mol Sci, 2022
O-Sullivan I, Kc R, Singh G, Das V, Ma K, Li X, Mwale F, Votta-Velis G, Bruce B, Natarajan Anbazhagan A, van Wijnen AJ, Im HJ.   +11 more
europepmc   +1 more source

Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. [PDF]

, 2007
OBJECTIVE: The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes.
Jimenez, Sergio A., Roman-Blas, Jorge A., Stokes, David G.   +2 more
core   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Proteomics Profiling of Human Synovial Fluid Suggests Increased Protein Interplay in Early-Osteoarthritis (OA) That Is Lost in Late-Stage OA. [PDF]

Mol Cell Proteomics, 2022
Ali N, Turkiewicz A, Hughes V, Folkesson E, Tjörnstand J, Neuman P, Önnerfjord P, Englund M.   +7 more
europepmc   +1 more source