Results 41 to 50 of about 497,266 (304)

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Targeting Some Key Metalloproteinases by Nano-Naringenin and Amphora coffeaeformis as a Novel Strategy for Treatment of Osteoarthritis in Rats

Pharmaceuticals, 2023
Osteoarthritis (OA) represents the highest degenerative disorder. Because cartilage erosion is a common pathological alteration in OA, targeting some key metalloproteinases such as MMP-3, ADAMTS-5 besides their inhibitor TIMP-3 by natural products, could
Nema S. Shaban, Abeer M. Radi, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rasha Hamed Al-Serwi, Randa M. Hassan, Eman T. Mohammed, Rania A. Radi, Fatma M. Halfaya   +8 more
doaj   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Patients Perceive Subtalar Osteoarthritis to Be as Severe as Ankle Osteoarthritis: A Prospective Cohort Study

Foot & Ankle Orthopaedics
Research Type: Level 2 - Prospective comparative study, Meta-analysis of Level 2 studies or Level 1 studies with inconsistent results Introduction/Purpose: The literature has demonstrated that ankle osteoarthritis (OA) is at least as disabling as end ...
Marianne Koolen MD, PhD, MSc, Carlos Albarrán Rodriquez MD, MSc, Tudor Trache MD, Sultan Alharbi MD, Oliver Gagne MD, Andrea Veljkovic MD, MPH, Murray Penner MD, Kevin Wing MD, Alastair Younger MD, MSc, FRCSC   +8 more
doaj   +1 more source

Downregulation of miR-34a Promotes Proliferation and Inhibits Apoptosis of Rat Osteoarthritic Cartilage Cells by Activating PI3K/Akt Pathway

Clinical Interventions in Aging, 2020
Haitao Tao, Lei Cheng, Ruixiang Yang Orthopedic Surgery, The 3rd People’s Hospital of Qingdao, Qingdao 266041, People’s Republic of ChinaCorrespondence: Ruixiang YangOrthopedic Surgery, The 3rd People’s Hospital of Qingdao, No.
Tao H, Cheng L, Yang R
doaj  

Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis during Stair-Stepping: A Case-Control Study [PDF]

Annals of Applied Sport Science, 2022
Background. Patellofemoral osteoarthritis (PF OA) is a leading cause of significant pain and disability of the knee joint. Stair climbing dysfunction is commonly reported in this cohort. Objectives.
Jilan Adel, Alaa Eldin Balbaa, Hala R. ElHabashy, Mai R. Ibraheem, Nadia Fayaz, Samar Abbass, Amany ElZawahry, Hamda Ahmad Hamda, Amina Awad   +8 more
doaj  

Chronic neck pain is associated with increased mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study

Arthritis Research & Therapy, 2023
Background Neck pain (NP) is a common symptom reported in the elderly. However, no study has examined the relationship between NP and osteoarthritis (OA) so far, and this study aimed to investigate the association of neck pain with the prevalence and ...
Xi Chen, Lihua Gong, Cheng Li, Siyuan Wang, Yixin Zhou   +4 more
doaj   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis

BMC Musculoskeletal Disorders, 2019
Background Chronic low back pain (cLBP) affects millions of Americans and costs billions. Studies suggest a link between cLBP and joint hypermobility.
Adam P. Goode, Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, Portia Flowers, Jordan B. Renner, Joanne M. Jordan, Yvonne M. Golightly   +10 more
doaj   +1 more source

Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization

Diagnostics, 2022
Osteoarthritis (OA) is the major cause of disability, affecting over 30 million US adults. Continued research into the role of neovascularization and inflammation related to osteoarthritis in large-animal models and human clinical trials is paramount ...
Reza Talaie, Pooya Torkian, Alexander Clayton, Stephanie Wallace, Hoiwan Cheung, Majid Chalian, Jafar Golzarian   +6 more
doaj   +1 more source