Results 151 to 160 of about 497,266 (304)

An Investigator-Initiated, Prospective, Single-Center, Open-Label Clinical Study to Evaluate Safety and Performance of Intra-Articular Hyaluronic Acid (IA-HA) (Biovisc Ortho) in Patients with Osteoarthritis (OA) of the Knee. [PDF]

Clin Pharmacol, 2021
Gupta A, Channaveera C, Anand V, Sethi S.   +3 more
europepmc   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Can Ultrasound Guide Treatment Decisions in Difficult‐to‐Treat Rheumatoid Arthritis?

Arthritis &Rheumatology, EarlyView.
Danila Madonna, Richard J. Wakefield, Emilio Filippucci, Kulveer Mankia, Shouvik Dass, Dennis McGonagle, Paul Emery, Andrea Di Matteo   +7 more
wiley   +1 more source

Mechanical memory in aging: From adaptive sensing to pathological entrenchment

Interdisciplinary Medicine, EarlyView.
Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang, Xiaoyu Ma, Ruiqi Gao, Qichen Miao, Guoqing Wang, Ziyuan Liu, Kun Wang, Ming Luo   +7 more
wiley   +1 more source

Update of clinical aspects of knee osteoarthritis: data mining from NMR-based metabolomics of synovial fluid

Clinical and Biomedical Research
Introduction: Knee osteoarthritis (OA) is a prevalent disease which leads to progressive disability. There is increasing evidence of the association between OA with metabolic syndrome.
Mario Correa Netto Pacheco Junior, Ramon Pinheiro Aguiar, Diego Pinheiro Aguiar, Gilson Costa dos Santos Junior, Eduardo Branco de Sousa   +4 more
doaj  

Low‐Field MRI for Knee Imaging: Current Insights and Evidence From a Systematic Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Low‐field magnetic resonance imaging (MRI) has regained interest for musculoskeletal imaging due to advances in magnet design, hardware optimization, and artificial intelligence (AI)–based reconstruction, offering improved accessibility, patient comfort, and sustainability.
Switinder Singh Ghotra, Cláudia dos Sá dos Reis, Allison McGee, Jonathan P. McNulty   +3 more
wiley   +1 more source

Quantitative UTE MRI Differences in the Meniscus Following ACL Reconstruction: A Prospective Cohort Study Using 3D Ultrashort Echo Time Adiabatic T1rho and Magnetization Transfer Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background ACLR is associated with altered joint loading and increased risk of post‐traumatic osteoarthritis. Conventional MRI has limited sensitivity to early meniscal differences because of short‐T2 signal decay and magic‐angle effects. Purpose To evaluate whether 3D ultrashort echo time imaging‐based adiabatic T1rho (UTE‐Adiab‐T1rho) and ...
Jiayang Wu, Dina Moazamian, Donghyun Kim, Jiaji Wang, Mohamad Amin Cheraghi, Hamidreza Shaterian Mohammadi, Bhavsimran Malhi, Jiyo Athertya, Yajun Ma, Eric Chang, Chang Yang, Saeed Jerban, Susan Bukata, Christine Chung, Jiang Du   +14 more
wiley   +1 more source

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Letter to the Editor Regarding: "Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?" [PDF]

Int J Rheum Dis
Deb G, Sharma S.
europepmc   +1 more source