Results 241 to 250 of about 197,424 (329)

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

CXCL1 Promotes Osteoblast Autophagy and Inhibits Ferroptosis Through the Activation of the TGF-β/Smad Signalling Pathway. [PDF]

J Cell Mol Med
Zhou Z, Wang Y, Gao Z, Chen Q, Wu H, Sun J, Li H, Liu D, Shen Y.   +8 more
europepmc   +1 more source

Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing [PDF]

, 2020
He, Guangxu, Liao, Lele, Liu, Xiaochen, Long, Fanxin, Ni, Jiangdong, Silva, Matthew J., Song, Deye, Song, Fangfang, Wang, Zhepeng   +8 more
core   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Venous Endothelial Cells Promote Osteoblast Differentiation More Effectively Than Arterial Cells via TGF-β/BMP9 and Notch Pathway-Related Gene Expression. [PDF]

Cell Biochem Funct
Fernandes CJC, Foganholi da Silva RA, Ferreira MR, Zambuzzi WF.   +3 more
europepmc   +1 more source

An in vivo assay for osteoclast activity using mouse calvaria

Animal Models and Experimental Medicine, EarlyView.
This study describes a novel method for measuring osteoclast‐mediated bone resorption in vivo using a mouse model. Localized injection of RANKL in a basement membrane matrix above the cranium induced osteoclast‐mediated bone resorption. Utilizing micro‐computed tomography and a semiautomated three‐dimensional analysis program, osteoclast resorption pit
Christopher Grieg, Maya Deza Culbertson, J. Patrick O'Connor   +2 more
wiley   +1 more source

The role of ferroptosis in osteoporosis: from pathogenic mechanisms to natural product-driven therapeutic innovations. [PDF]

Front Med (Lausanne)
Zhu Y, Wu X, Peng X, He H, Hu Z, Xiao L.
europepmc   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Effects of Cannabidiol on Bone Health: A Comprehensive Scoping Review. [PDF]

Biomedicines
Shakir SA, Chin KY.
europepmc   +1 more source

Subchondral bone osteoblasts can induce chondrocyte mineralization during osteoarthritis and this process is relevant to cartilage degradation

, 2008
Indira Prasadam, Wei Shi, Ross Crawford, Yin Xiao   +3 more
openalex   +2 more sources