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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells
Cells Tissues Organs, 2008<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun +3 more
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Regulation of Osteoblast Activity and the Osteoblast-Osteocyte Transformation
1982According to currently held concepts of bone formation (Table 1), osteoblasts develop from mitotically competent marrow stromal cells by a process of non-mitotic differentiation (modulation) (1,2). Osteoblasts are attracted to the bone surfaces, and are activated to elaborate lamellae of collagen-rich organic matrix (osteoid) which is subsequently ...
W A, Peck, L, Rifas
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Blood, 2008
In this issue of Blood , Mayak and Wagers report on a new method to isolate putative osteoblastic cells that can regulate hematopoietic stem cell proliferation and function. The cellular and extracellular matrix components that support and regulate hematopoietic stem cells (HSCs) form niches ...
Daniel, Lucas, Paul S, Frenette
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In this issue of Blood , Mayak and Wagers report on a new method to isolate putative osteoblastic cells that can regulate hematopoietic stem cell proliferation and function. The cellular and extracellular matrix components that support and regulate hematopoietic stem cells (HSCs) form niches ...
Daniel, Lucas, Paul S, Frenette
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Osteoclast–osteoblast communication
Archives of Biochemistry and Biophysics, 2008Cells in osteoclast and osteoblast lineages communicate with each other through cell-cell contact, diffusible paracrine factors and cell-bone matrix interaction. Osteoclast-osteoblast communication occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling.
Koichi, Matsuo, Naoko, Irie
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Medical Hypotheses, 2012
Bisphosphonates are used in the oncological setting to treat and prevent skeletal-related events and preserve bone mineral density. Bisphosphonates also possess a hypocalcaemic effect. When undesired, hypocalcaemia can result in increased morbidity and complications.
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Bisphosphonates are used in the oncological setting to treat and prevent skeletal-related events and preserve bone mineral density. Bisphosphonates also possess a hypocalcaemic effect. When undesired, hypocalcaemia can result in increased morbidity and complications.
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Transcription factors and osteoblasts
Frontiers in Bioscience, 1998Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues.
M, Noda +7 more
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Osteoblast and chondroblast differentiation
Bone, 1995Recognition of discrete commitment and differentiation stages requires characterization of changes in proliferative capacity together with the temporal acquisition or loss of expression of molecular and morphological traits. Both cell lines and primary cultures have been useful for analysis of transitional steps in the chondroblast (CB) and osteoblast (
J E, Aubin +3 more
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Osteoblast function in myeloma
Bone, 2011Multiple myeloma (MM) is the most frequent cancer to involve the skeleton and results in purely osteolytic lesions that rarely heal. MM bone disease is responsible for some of the most devastating complications of MM. The marrow microenvironment plays a key role in MM bone disease as well as in the initiation, expansion and chemoresistance of MM cells.
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Properties and Origin of Osteoblasts
Clinical Orthopaedics and Related Research, 1990Osteoblastic and chondroblastic (i.e., osteogenic) cells belong to the stromal cell system, which is associated with bone marrow, and bone and is separate from the hematopoietic stem-cell system. Stromal stem cells are capable of producing reticular, fibroblastic, osteogenic, and adipose stromal lines. Marrow-derived osteogenic cells are a component of
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