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PKCα suppresses osteoblastic differentiation

PKCα suppresses osteoblastic differentiation
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Osteoblast Differentiation

Encyclopedia of Bone Biology, 2020
Fanxin Long
semanticscholar   +2 more sources

Osteoblastic cells: Differentiation and trans-differentiation

Archives of Biochemistry and Biophysics, 2008
The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that ...
Kassem, Moustapha, Abdallah, Basem, Saeed, Hamid   +2 more
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Exosomal miRNA-486-5p derived from rheumatoid arthritis fibroblast-like synoviocytes induces osteoblast differentiation through the Tob1/BMP/Smad pathway.

Biomaterials Science, 2020
The pathogenesis of rheumatoid arthritis (RA) is related to the inhibition of osteoblast differentiation. Exosomes secreted from RA fibroblast-like synoviocytes (RA-FLSs-exos) are associated with the pathogenesis of RA and microRNAs (miRNAs) being ...
Jie Chen, Mao Liu, Xiao Luo, Lihui Peng, Zixia Zhao, Chengsong He, Yue He   +6 more
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MEK5 suppresses osteoblastic differentiation

Biochemical and Biophysical Research Communications, 2015
Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and is activated by its upstream kinase, MAPK kinase 5 (MEK5), which is a member of the MEK family. Although the role of MEK5 has been investigated in several fields, little is known about its role in osteoblastic differentiation.
Shoichi, Kaneshiro, Dai, Otsuki, Kiyoshi, Yoshida, Hideki, Yoshikawa, Chikahisa, Higuchi   +4 more
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Insulin facilitates osteoblast differentiation

Cell Biology International, 2013
AbstractTissue engineering of bone has been increasingly used in the bone defect repair. To generate osteoblasts is a major approach, and here we have examined ways of improving the efficiency of producing osteoblasts. Adipose stem cells (ADSC) were prepared from rat mesentery tissue, and transfected with Cbfa1 gene vector or/and IGF‐1R gene vector ...
Lin, Wang, Hongwei, Wang, Xia, Xu, Dongshen, Wang, Hongchen, Liu   +4 more
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PKCα suppresses osteoblastic differentiation

Bone, 2011
Protein kinase C (PKC) plays an essential role in cellular signal transduction for mediating a variety of biological functions. There are 11 PKC isoforms and these isoforms are believed to play distinct roles in cells. Although the role of individual isoforms of PKC has been investigated in many fields, little is known about the role of PKC in ...
Akio, Nakura, Chikahisa, Higuchi, Kiyoshi, Yoshida, Hideki, Yoshikawa   +3 more
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Osteoblast and chondroblast differentiation

Bone, 1995
Recognition of discrete commitment and differentiation stages requires characterization of changes in proliferative capacity together with the temporal acquisition or loss of expression of molecular and morphological traits. Both cell lines and primary cultures have been useful for analysis of transitional steps in the chondroblast (CB) and osteoblast (
J E, Aubin, F, Liu, L, Malaval, A K, Gupta   +3 more
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Inorganic Polyphosphate Induces Osteoblastic Differentiation

Journal of Dental Research, 2010
Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time reverse-transcription polymerase ...
Y, Usui, T, Uematsu, T, Uchihashi, M, Takahashi, M, Takahashi, M, Ishizuka, R, Doto, H, Tanaka, Y, Komazaki, M, Osawa, K, Yamada, M, Yamaoka, K, Furusawa   +12 more
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Proteomic profiling of differentiating osteoblasts

Expert Review of Proteomics, 2006
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into bone-forming, differentiating osteoblast cells. Osteoblast differentiation is the primary event of bone formation, exemplified by the synthesis, deposition and mineralization of extracellular matrix. Osteoblast differentiation is controlled tightly by sequential
Josip, Blonder, Zhen, Xiao, Timothy D, Veenstra   +2 more
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