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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells
Cells Tissues Organs, 2008<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun +3 more
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Ciba Foundation symposium, 1989
The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide +2 more
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The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide +2 more
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Osteoblast differentiation during orthodontic tooth movement
Orthodontics & Craniofacial Research, 2019AbstractObjectivesTo analyse the expression of osteoblast differentiation markers and osteoclast activity in the periodontal ligament (PDL) following 2, 4 and 7 days of orthodontic tooth movement (OTM) in an animal model.Setting and Sample PopulationEighteen C57BL/6 wild‐type mice.Material and MethodsFor the OTM model, orthodontic force was applied to ...
Robert Holland +2 more
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Collagen Cross-Linking Influences Osteoblastic Differentiation
Calcified Tissue International, 2008Osteoblasts synthesize collagen matrix, which itself regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase (LOX), which is involved in the collagen cross-linking process. Lathyrogens, like ss-aminopropionitrile (ssAPN), inhibit the formation of a stable matrix.
C, Turecek +9 more
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Transcriptional profiling of human osteoblast differentiation
Journal of Cellular Biochemistry, 2003AbstractOsteoblast differentiation is a key aspect of bone formation and remodeling. To further our understanding of the differentiation process, we have developed a collection of conditionally immortalized adult human osteoblast cell lines representing discrete stages of differentiation.
J, Billiard +7 more
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Osteoblasts: Differentiation and Function
1993Cells of the osteoblast lineage occupy a central position in bone metabolism. The formation of a structurally sound skeleton, with its strength and integrity conserved by constant remodeling, and the formation as well as activation of the major bone-resorbing cell, the osteoclast, are the result of direct and indirect influences of osteoblasts.
T. J. Martin +3 more
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Differentiation of Osteoblasts on Pectin-Coated Titanium
Biomacromolecules, 2008The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports osteoblast differentiation.
Kokkonen, H. +5 more
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Osteosarcoma and Osteoblastic Differentiation
Clinical Orthopaedics and Related Research, 2007In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma.
Rex C, Haydon +2 more
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2014
Insulin like growth factor binding protein two (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation.
Rosen, Clifford J +4 more
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Insulin like growth factor binding protein two (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation.
Rosen, Clifford J +4 more
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Regulation of Osteoblast Differentiation by Runx2
2009Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
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