Results 161 to 170 of about 79,934 (285)

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Effects of 14 days of head‐down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults

Experimental Physiology, EarlyView.
Abstract Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head‐down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in older adults. Twenty‐two healthy older adults (55–65 years) completed the HDBR protocol.
Guy Hajj‐Boutros, Andréa Faust, Carmelo Mastrandrea, Vita Sonjak, Dounia Rouabhia, Gustavo Duque, Richard Kremer, Stéphanie Chevalier, Julie Lacombe, Mathieu Ferron, Tyler A. Churchward‐Venne, José A. Morais   +11 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source

The History of the Discovery of Vitamin K

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Vitamin K was discovered during the 1930s when a strange haemorrhagic disorder was observed in chickens fed a cholesterol‐free diet. A fat‐soluble agent, present in green leafy vegetables and hog liver, was able to restore haemostasis in the chickens.
Hanna Nørgaard Tuxen, Laila Zwisler, Allan Linneberg   +2 more
wiley   +1 more source

High-Intensity Training Increases Osteocalcin Levels: A Meta-Analysis of Effects of Exercise on Bone Remodeling biomarkers. [PDF]

Sports Med Open
Barna V, Makolli A, Benyó ZP, Engh MA, Zolcsák Á, Teutsch B, Seymour V, Hegyi P, Papp R, Sydo N, Ferdinandy P.   +10 more
europepmc   +1 more source