Advanced Materials, Volume 38, Issue 45, 13 August 2026.A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu +7 more
wiley +1 more source
Stage-dependent analysis of IL-6, TGF-β, osteocalcin, and sRANKL in the synovial fluid of dogs with osteoarthritis. [PDF]
Sci RepNeumann S, Diekmann H, Lauenstein S.
europepmc +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, Volume 13, Issue 46, 17 August 2026.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Circulating Total Osteocalcin Reflects Bone Mineral Physiology Rather than Metabolic Risk in Pediatric Obesity. [PDF]
NutrientsNowicki JK +3 more
europepmc +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, Volume 13, Issue 44, 7 August 2026.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Rapid improvement in glycaemic control is associated with increased circulating osteocalcin in type 2 diabetes: a concise observational comparative study. [PDF]
BMC Endocr DisordDardari D +5 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che +9 more
wiley +1 more source
Beyond 25(OH)D: Carboxylated Osteocalcin and the Undercarboxylated/Carboxylated Osteocalcin Ratio as Superior Biomarkers for Vitamin D Recovery in Offspring Affected by Maternal Deficiency. [PDF]
NutrientsChan WT +7 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
RETRACTION: Effects of Osteocalcin on Synthesis of Testosterone and INSL3 during Adult Leydig Cell Differentiation. [PDF]
Int J EndocrinolEndocrinology IJO.
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