Results 301 to 310 of about 109,289 (351)

Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells

Journal of Bone and Mineral Research, 2012
Hiroya Miyamoto, Takayuki Suzuki, Yoshiteru Miyauchi, R. Iwasaki, Tami Kobayashi, Yuiko Sato, K. Miyamoto, H. Hoshi, Kazuaki Hashimoto, S. Yoshida, Wu Hao, Tomoaki Mori, H. Kanagawa, E. Katsuyama, Atsuhiro Fujie, H. Morioka, M. Matsumoto, K. Chiba, M. Takeya, Y. Toyama, T. Miyamoto   +20 more
semanticscholar   +1 more source

Cochlear Cell Atlas of Two Laryngeal Echolocating Bats—New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat

Molecular Ecology Resources, EarlyView.
ABSTRACT Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high‐frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis
Xue Wang, Mingyue Bao, Hui Wang, Ruyi Sun, Wentao Dai, Keping Sun, Yue Zhu, Yingting Pu, Yujia Chu, Xintong Li, Tianhui Wang, Minjie Zhang, Aiqing Lin, Jiqian Li, Jiang Feng   +14 more
wiley   +1 more source

P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice

Aging Cell, Volume 24, Issue 5, May 2025.
Inhibition of the P2Y2 receptor with AR‐C118925XX (ARC) inhibits osteocytes induction of osteoclast differentiation. Treating adult mice with ARC prevents age‐related bone loss and increase endocortical bone formation. At the same time, ARC also enhances the anabolic response to exercise in aged mice by increasing the degree of periosteal bone ...
Amit Chougule, Chunbin Zhang, Jordan Denbow, Nickolas Vinokurov, Devin Mendez, Elizabeth Vojtisek, Joseph Gardinier   +6 more
wiley   +1 more source

Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact [corrected and republished with original paging, article originally printed in Endocrinology 1996 May;137(5):2187-90]

, 1996
Eijiro Jimi
openalex   +1 more source

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, EarlyView.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty

Acta Paediatrica, Volume 114, Issue 5, Page 944-953, May 2025.
Abstract Aim To analyse the association between bone turnover markers and bone mass in children and young adults. Methods This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school‐based intervention study (2000–2017).
Jakob Rempe, Björn E. Rosengren, Lars Jehpsson, Per Swärd, Magnus Dencker, Magnus K. Karlsson   +5 more
wiley   +1 more source

hnRNP A1, hnRNP A2B1, and hnRNP K are dysregulated in tauopathies, but do not colocalize with tau pathology

Brain Pathology, Volume 35, Issue 3, May 2025.
Diversity of hnRNP A1, hnRNP A2B1, and hnRNP K immunostaining across hippocampal subregions in Alzheimer's disease. Abstract Tau interacts with multiple heterogeneous nuclear ribonucleoproteins (hnRNPs)—a family of RNA binding proteins that regulate multiple known cellular functions, including mRNA splicing, mRNA transport, and translation regulation ...
Tomas Kavanagh, Kaleah Balcomb, Diba Ahmadi Rastegar, Guinevere F. Lourenco, Thomas Wisniewski, Glenda Halliday, Eleanor Drummond   +6 more
wiley   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

The Use of miRNA Panel as a Growth Plate Marker of Short‐Term Response to GH

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Recombinant human growth hormone (GH) therapy shows variable growth responses in patients with growth hormone deficiency (GHD), highlighting the need for reliable biomarkers to predict individual sensitivity. Objective This study investigated circulating microRNAs (miRNAs) involved in growth plate regulation during GH therapy in ...
Caroline Rosa Pellicciari, Thayna Rosa Bispo, Itatiana Ferreira Rodart, Leandra Steinmetz, Adriana Aparecida Siviero Miachon, Angela Maria Spinola e Castro, Durval Damiani, Cristiane Kochi, Carlos Alberto Longui   +8 more
wiley   +1 more source